This work purported to investigate the 'technological pedagogical and content knowledge' of public and private primary school teachers in district Matiari, Sindh. Quantitative data were gathered through a cross-sectional survey with a sample of 97 teachers teaching at primary level in district Matiari. TPACK survey instrument by Schmidt et al. (2009) was used after translation into the national nomenclature, i.e., Urdu and the local language of Sindh, i.e., Sindhi to fit the milieu of Sindh. Data was analysed using descriptive statistics, correlation and MANOVA. The survey discovered that teachers rated themselves higher on TPACK while in the sub domains of TPACK, they received the highest scores in 'Pedagogical Knowledge' (PK). All teachers generally scored lowest in 'Technological Knowledge' (TK) and 'Technological Content Knowledge' (TCK). A comparative analysis was executed between the two groups of the teachers and it was found that teachers from government schools scored more than their counterparts from the private sector. From a gender position, female primary school teachers scored more than their counterparts and female teachers from private school scored higher than their male counterparts as well as teachers from public school.