موسیٰ جاراﷲ
دوسرا علمی حادثہ دنیائے اسلام کے مشہور عالم موسیٰ جار اﷲ کی وفات ہے ، ان کا وطن روسی ترکستان تھا، وہ بڑے وسیع النظر عالم اور زندہ کتب خانہ تھے، اور ہر موضوع اور ہر فن پر مجتہدانہ نگاہ رکھتے تھے، روسی ترکی اور عربی فارسی میں پوری مہارت رکھتے تھے، اردو بھی ٹوٹی پھوٹی بول لیتے تھے، ایک زمانہ تک لینن کے رفیق اور شریک کار رہے، پھر کسی اختلاف کی بنا پر جلا وطن کردیے گئے ، جلاوطنی کے زمانہ میں انھوں نے تمام اسلامی ملکوں کی سیاحت کی، اس سلسلہ میں ہندوستان بھی آئے، اور کئی سال تک دہلی اور بھوپال میں مقیم رہے، چودہ پندرہ سال ہوئے دارالمصنفین بھی آئے تھے اور ہفتہ عشرہ قیام رہا تھا، ان کے علمی شغف و انہماک کو دیکھ کر علمائے سلف کی یاد تازہ ہوتی تھی، ان کا سارا وقت اور رات کا بڑا حصہ مطالعہ میں گزرتا تھا، انھوں نے اس مختصر قیام میں دارالمصنفین کے پورے کتب خانے کا جائزہ لے لیا تھا، تالیف و تصنیف کا شغل بھی تھا، عربی میں ان کی بہت سی تصانیف مسودہ کی صورت میں تھیں، لیکن چند مختصر رسالوں کے علاوہ کسی بڑی تصنیف کی اشاعت کی نوبت نہیں آئی، جب سے وہ وطن سے نکلے پھر دوبارہ جانا نصیب نہیں ہوا، اور عالمِ غربت ہی میں گذشتہ مہینہ مصر میں سفرِ آخرت کیا ، اﷲ تعالیٰ اس شیدائے علم کو اپنی رحمت و مغفرت سے سرفراز فرمائے۔
(شاہ معین الدین ندوی،جنوری ۱۹۵۰ء)
موسیٰ جاراﷲ ؒکی بعض تصانیف
( مولانا عبدالمجید حریری)
’’ہمارے فاضل اور محترم دوست مولانا عبدالمجید صاحب حریری ان علم دوست اصحاب میں ہیں جن کے تعلقات ہندوستان و بیرون ہند کے بہت سے علماء مشاہیر سے ہیں اور بنارس میں ان کا دولت کدہ اصحاب علم...
Human beings have been created in proportion and perfection by the Creator, as He is Just and Fair and likes justice and fairness in making and implementing laws. Justice is the key on every level from individual to State and interstate for peaceful and smooth functioning. Justice holds universal acceptance from the laws of nature to the creation of beings, while injustice leads to chaos. It causes the decline and disgrace among civilized societies. The chaos and terrorism in contemporary world is all because of injustices by individuals and by the States. The teachings of the messangers of Allah were to create the justice and equality at every level in the society. Deviation from the teachings of Allah and His messangers with respect to justice is a way towards destruction. Any nation that forgoes justice becomes victim of injustice itself and the consequences are ultimate anarchy and chaos. Islam as a universal religion demands the justice in every sphere of life. Islam and its teachings are for peace and prosperity. It promulgates and promotes human dignity and the value of Justice, equality and peace. Today the Ummah is in desperate need of adopting and practicing justice and fairness as the Creator has shown in His Word and Work.
A chemical library of small drug-like heterocylic compounds, 2,3-dihydro-1,5- benzothiazepines was synthesized using Silica gel as an inorganic support. All the synthesized 2,3-dihydro-1,5-benzothiazepines were obtained in excellent yields. Another library of 1,4-disubstituted-1,2,3-triazoles was synthesized by a Cu(I) catalyzed click reaction, where organic azides, with electron donating and electron withdrawing groups acted as 1,3-dipoles and 1-ethynyl-1-cyclohexanol and acetylene served as the terminal alkyne counterparts. The [3+2] cycloaddition was highly regiospecific and lead exclusively to 1,4-disubstituted triazoles in high yields. Seven sets of triazoles were synthesized, the synthesized triazoles were obtained in good yields. Some hetero-aryl 1,2,3-triazoles were also synthesized successfully in good yields. “On water”, one pot synthesis of triazoles of set 4, under the same click conditions was also employed. The method proved to be facile and more economic. Characterization of all the synthesized 2,3-dihydro-1,5-benzothiazepines, azides and triazoles was carried out through their physical constants and spectroscopic data. Regioselective chiral synthesis of peptides and iso-peptides was also carried out by employing benzotriazole mediated synthesis where benzotriazole acts as both activating and leaving group. All the synthesized peptides were obtained in good to excellent yields with retention of original chirality as confirmed through the single set of signals in 1 H and 13 C NMR spectra. Peptidyl triazoles were also synthesized for fragment based coupling to obtain longer chain iso-peptides. Microwave assisted OàN acyl migration in iso-tri peptides and iso-tetrapeptide was carried out for the synthesis of native peptides from iso-peptides. Moreover Traceless Native Chemical Ligation (TNCL) on the serine site was successfully achieved through 8- and 11- membered transition states in iso-tri- and iso-tetrapeptides respectively. The synthesized chemical libraries of heterocycles were screened for their potential as, α-glucosidase and Butyrylcholinesterase (BChE) inhibitors, BChE is a tetrameric glycoprotein BChE, distributed in the body of vertebrates specially Central Nervous System (CNS). Some 1,4-di-substituted 1,2,3-triazoles such as 37, 40, 45, 53 and 60 were found active against α-glucosidase and BChE. These dual inhibitors may be important for developing drugs for the treatment of AD and T2D. Peptides and iso- iiiAbstract peptides were subjected to chemo-preventive assays on breast cancer cell lines along with cytotoxicity assays. Some of these peptides exhibited moderate activities against cancer cell lines. Antibacterial and antifungal activities of synthesized heterocycles and peptides were also studied but activities were not remarkable. Computational studies were carried out on active compounds, with an objective to provide an insight to binding mode analysis of active compounds against different targets by using the molecular docking tools and physical descriptor module of Molecular Operating Environment (MOE). All the compounds except few deviations from only one parameter, showed compliance with Ro5 and hence found to be druglike. Human BChE (PDB code:1POI) was selected for docking studies of active compounds. Homology modeling of α-glucosidase was carried out for maximum sequence similarity. Modeled α- glucosidase was used for molecular docking studies. A good relationship was observed between the activity and ligand receptor interaction of active compounds. Molecular docking of peptides were also carried out against kinases and two of the proteins were imported from the protein data bank with PDB codes, 3BRT (1kkα) and 3BRV (1kkβ) respectively. The binding mode was analyzed by studying ligand-receptor complex interaction of these peptides.
