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Home > A Randomised Comparative Trial of Seven Versus Fourteen Day Triple Therapy for Helicobacter Pylori Eradication at the Aga Khan University Hospital, Nairobi

A Randomised Comparative Trial of Seven Versus Fourteen Day Triple Therapy for Helicobacter Pylori Eradication at the Aga Khan University Hospital, Nairobi

Thesis Info

Author

Sokwala, Ahmed

Department

Internal Medicine (East Africa)

Program

MMed

Institute

Aga Khan University

Institute Type

Private

City

Karachi

Province

Sindh

Country

Pakistan

Thesis Completing Year

2010

Thesis Completion Status

Completed

Subject

Medicine

Language

English

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676728032646

Similar


Background: Helicobacter is associated with a number of important upper gastrointestinal conditions including chronic gastritis, peptic ulcer disease, and gastric malignancy. Proton pump inhibitor -based triple therapies are considered the standard regimens for Helicobacter pylori eradication, but the optimal duration of these regimens is still controversial. Local studies are required to evaluate the H. pylori eradication rates in a country for adequate eradication to prevent H. pylori infection and complications Objectives: The main objective of this study was to compare 7 day and 14 day regimens and determine the optimum duration of triple therapy for H. pylori eradication. Methods: A prospective randomised comparative trial of 7 and 14 day H. pylori eradication triple therapy at the Aga Khan University Hospital Nairobi. One hundred and twenty patients with dyspepsia and H. pylori infection were randomized to receive esomeprazole, amoxicillin and clarithromycin for either 7 days (EAC 7) or 14 days (EAC 14). Compliance and side affects were assessed two weeks after start of therapy and H. pylori eradication was assessed by H. pylori stool antigen done four weeks after treatment. Results: Both the intention-to-treat (ITT; n = 120) and per protocol (PP; n = 97) analyses showed no significant differences between the eradication rates of EAC 7 (ITT 76.7%; PP 92%) and EAC 14 (ITT 73.3%; PP 93.6%; ITT p = 0.67; PP p = 0.76). Poor compliance was reported in only one patient who was in EAC 14 group. Incidences of adverse events were comparable. Conclusion: 1-week and 2-week triple treatments for H. pylori eradication are similar in terms of efficacy, safety and patient compliance.
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عداوتوں کو تیرگی، وفا کو روشنی کہا

عداوتوں کو تیرگی ، وفا کو روشنی کہا
تمام عمر ہم نے تو جو سچ تھا بس وہی کہا

کوئی غلط نہیں یہاں ہے اپنا اپنا نظریہ
کوئی کہے ہوس ہے عشق میں نے تشنگی کہا

یہ روز و شب کے حادثوں میں ہر گھڑی کی موت کو
مجھے دکھاؤ شخص وہ کہ جس نے زندگی کہا

چھڑا کبھی جو تذکرہ تمھارے حسن کا تو پھر
بہارِ جاں کسی نے تو، کسی نے ساحری کہا

کسی نے پوچھا جب کبھی جو فلسفہ حیات کا
سمیٹ کر شعورِ عشق ہم نے شاعری کہا

ظاهرة تزويج القاصرات من منظور شرعي

According to traditional-religious-culture the early age marriages are very common custom especially in rural areas. The act of marring girls in early ages is considered to be a good practice in these constituencies; in contrast, the holy Quran has provided some logical guidelines to reject this idea. In the holy Quran “men” are instructed to marry as per their choice, which reveals, it is necessary for a “man” to be adult (Baligh) for marriage. Considering this fact, how it is possible that a man can be permitted to have a non-adult (Nabaligh) life partner? In this regard, marriages between Adult and Non-adult, Non-adult and Non-adult are not permitted because it is against the right of equality. Further, the holy Quran instructs the guardians of the orphans to return them their valuables when reach to the age of Nikah; which reveals that there is a particular standard of age set for Nikah, if it is not so, why the holy Quran has made this bounding for the guardians of the orphans? As per the guidance of the holy Quran, it is clear that Nikah requires both man and women not only to be physically adult/mature but also mentally adult/mature. In this connection, it has been highlighted that Nikah which is a physical contract requires a particular age for man and woman which however cannot be an age of Non-adult.

Morpho-Chemical Characterization of Different Sorghum Genotypes for Nutritional Quality Attributes under Irrigated and Rainfed Conditions

An adequate supply of better quality fodder is necessary to keep animal healthy and productive. Fodder crops provide cheaper feed for animals and play an important role in supplying the necessary nutrition to the livestock. Sorghum is a multi-purpose crop and plays a prime role in providing the fodder to the livestock. Most of the work in the past has been focused on increasing the yield of sorghum fodder but little efforts have been made so far on quality aspects. Keeping in view the importance of cyanide problem in deteriorating the quality of sorghum fodder, present study was conducted to evaluate different sorghum genotypes for fodder yield and its nutritional quality attributes under irrigated as well as rainfed condition. The research work comprising of four experiments, was performed on different sorghum genotypes at Department of Plant Breeding and Genetics, Pir Mehr Ali Shah Arid Agriculture University Rawalpindi. Major objectives of evaluation were to select best sorghum genotypes having higher fodder yield and minimum cyanide content and to find out the gene action governing the control of such traits and genetic variability in sorghum genotypes. Sorghum genotypes were examined for different morphological, biochemical and quality parameters under field as well as laboratory conditions. The performance of two sorghum genotypes viz V-1 and SV-6 was found excellent for total cyanide content, green fodder yield, total sugar content and crude protein under both irrigated as well as rainfed conditions during the two years evaluation. Drought condition resulted in reduction of green fodder yield but cyanide content boosted up under water stress during assessment in two years. Significant G x E interaction was observed during analysis for all the traits under evaluation indicating influence of environment on the performance of sorghum genotypes. Higher phenotypic and genotypic variance estimates than the environmental variance estimates was observed indicating that the variation are genetic in nature and are heritable. Fodder yield and its components showed negative correlation with cyanide content at genotypic and phenotypic levels. Fodder yield, cyanide content and crude protein depicted high heritability and expected genetic advance during study. Partial diallel technique (Circulant Design) given by Kempthorne and Curnow (1964) was utilized to find out the gene action involved in the hereditary transmission of the characters under assessment. The ratio between specific combining ability (SCA) and general combining ability (GCA) variances for all the characters under assessment was greater than unity indicating non additive type of gene action. The parent CVS-13 and SV-6 were found good general combiner for fodder yield and cyanide content respectively. Almost all the characters showed significant better parent heterosis for fodder yield and cyanide content during the study.