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Home > A Randomised Comparative Trial of Seven Versus Fourteen Day Triple Therapy for Helicobacter Pylori Eradication at the Aga Khan University Hospital, Nairobi

A Randomised Comparative Trial of Seven Versus Fourteen Day Triple Therapy for Helicobacter Pylori Eradication at the Aga Khan University Hospital, Nairobi

Thesis Info

Author

Sokwala, Ahmed

Department

Internal Medicine (East Africa)

Program

MMed

Institute

Aga Khan University

Institute Type

Private

City

Karachi

Province

Sindh

Country

Pakistan

Thesis Completing Year

2010

Thesis Completion Status

Completed

Subject

Medicine

Language

English

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676728032646

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Background: Helicobacter is associated with a number of important upper gastrointestinal conditions including chronic gastritis, peptic ulcer disease, and gastric malignancy. Proton pump inhibitor -based triple therapies are considered the standard regimens for Helicobacter pylori eradication, but the optimal duration of these regimens is still controversial. Local studies are required to evaluate the H. pylori eradication rates in a country for adequate eradication to prevent H. pylori infection and complications Objectives: The main objective of this study was to compare 7 day and 14 day regimens and determine the optimum duration of triple therapy for H. pylori eradication. Methods: A prospective randomised comparative trial of 7 and 14 day H. pylori eradication triple therapy at the Aga Khan University Hospital Nairobi. One hundred and twenty patients with dyspepsia and H. pylori infection were randomized to receive esomeprazole, amoxicillin and clarithromycin for either 7 days (EAC 7) or 14 days (EAC 14). Compliance and side affects were assessed two weeks after start of therapy and H. pylori eradication was assessed by H. pylori stool antigen done four weeks after treatment. Results: Both the intention-to-treat (ITT; n = 120) and per protocol (PP; n = 97) analyses showed no significant differences between the eradication rates of EAC 7 (ITT 76.7%; PP 92%) and EAC 14 (ITT 73.3%; PP 93.6%; ITT p = 0.67; PP p = 0.76). Poor compliance was reported in only one patient who was in EAC 14 group. Incidences of adverse events were comparable. Conclusion: 1-week and 2-week triple treatments for H. pylori eradication are similar in terms of efficacy, safety and patient compliance.
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خون جگر ہونے تک

خون جگر ہونے تک
اپنی کتاب کا دیباچہ لکھنا توحالیؔ جیسے لوگوں کو جچتا ہے جو دیباچہ لکھیں تو تنقید کی پہلی کتاب وجود پا جائے۔میں تو عاجزانہ طور پر چند عروضی نکات پیش کرنا چاہتا ہوں۔میرا یہ دیباچہ سب کے لیے نہیں ہے۔ اس کی دو وجوہات ہیں۔ ایک تو عروضی بحث اس قدر گنجلک اور پیچیدہ ہوتی ہے کہ ہر کسی کو اس سے شغف نہیں ہوتا اور دوسرا جو لوگ عروض پہ دسترس رکھتے ہیںان کے لیے اس وضاحت کی ضرورت نہیں کیوں کہ وہ عروض پہ اس دیباچے سے بہت بہتر کتابیں پڑھ چکے ہیں۔ یہ دیباچہ فقط ان لوگوں کے لیے ہے جو شعر کہتے ہیں اور عروض میں بھی ٹانگ اڑاتے ہیں اورجب کسی شعر کی بحر سمجھ نہ آئے تو اسے بے وزن کہہ دیتے ہیں۔زیادہ تر ہندی بحر کے سلسلے میںان کا رویہ ایسا ہوتا ہے اوراگر ان کے سامنے کسی بڑے شاعر کا مصرع بہ طور نمونہ رکھ دیا جائے تو وہ اسے بھی بے وزن کہنے سے ذرا نہیں ہچکچاتے۔ فاع فاعلن یا فعَل فعولن ان کی سمجھ سے باہر ہو جاتا ہے۔ دراصل ایسے حضرات ہندی بحر کی چند معروف صورتوں کے سوا باقی صورتوں سے آشنا ہی نہیں۔
میرا یہ شعری مجموعہ ہندی بحر میںہی تخلیق ہوا ہے اور ہندی بحر میں خاصا تنوع پایا جاتا ہے۔ہمارے وہ لوگ جو عروض کو سرسری طور پر جانتے ہیں۔اس بحر کو سمجھنے میں ٹھوکر کھاتے ہیں۔وہ ہندی بحر کی چندمعروف صورتوں سے ہی واقف ہیں۔وہ بس اِسے ہی ہندی بحر سمجھتے ہیں مگر ہندی بحر کی متنوع صورتیں ہیں۔ان حضرات کے سامنے اگر کوئی مختلف صورت آ جائے تو وہ اسے سمجھنے سے قاصر رہتے ہیں کیوں کہ وہ ان صورتوں سے آشنا ہی نہیں اور وہ اسی ناآشنائی میں اس مصرعے کو بے وزن کہہ دیتے...

اسلامی معاشیات میں امداد باہمی کا تصور

Islamic finance is simply a different way to structure or to create products that are consistent with the Islamic faith. Shared risk and joint profit are also important elements of Islamic finance, and various cooperative frameworks are employed in housing and other sectors. When you look at global finance, [Islamic finance] is a very, very high growth. Islamic finance is a socially responsible financial system and uses Islamic law (sharia) to regulate various sectors, including banking, investments, and insurance. Under the system, Islamic investments are often referred to as halal investments, or sharia-compliant investments. However we will discuss in this Paper the concept of mutual cooperation in Islamic finance.

Phytosanitary Management of Trogoderma Granarium Everts With Methyl Bromide Alternatives to Ensure Food Security and Safety

Wheat crop occupies a central position in agriculture sector and our national economy. Pakistan’s contribution toward global wheat production is about 3.2 percent. The Punjab province is leading producer of wheat with a share of more than 70 percent of the total wheat production of the country. Despite being an agricultural country, food security of Pakistan has remained at stake since long because of poor yield and high post harvest losses caused by the storage pests. On the other hand country has a great exporting potential not only to achieve Millennium Development Goals (MDGs) relating to food security and safety but can earn foreign exchange and pay off country’s entire debts within 10 years just equaling our yield to that of Indian Punjab. Present investigations were, therefore, carried out to explore these potentials in terms of reducing post-harvest losses, food security and safety risks caused by the storage pests particularly the Khapra beetle which is a notified quarantine pest internationally. The studies revealed an average loss of 15.5 percent when 10 pairs of Khapra larvae were released for a period of 6 months under the natural conditions. Similarly there were found 33 and 8 percent increase in number of weeviled and broken grains, respectively. Besides, the beetle depleted approximately 4 percent carbohydrates that resulted in 0.35 and 1 percent increase in ash and crude fiber contents, respectively. Although total protein and fat percentages were slightly increased, yet these increases were predominantly due to the percentage loss of carbohydrates as well as production of proteinaceous by-products of live insects, insect fragments, and excreta etc., which could not be sieved from the samples before chemical analysis. Further analysis of about 400 samples drawn from the entire province revealed that quality of Punjab wheat not only meets the international standards rather it is superior in many characteristics including protein content, moisture, bulk density, foreign matter, falling number. However, presence of quarantine pests such as T. granarium, Tilletia spores and Striga weeds render it unmarketable in the quality conscious world. A compatible Wheat crop occupies a central position in agriculture sector and our national economy. Pakistan’s contribution toward global wheat production is about 3.2 percent. The Punjab province is leading producer of wheat with a share of more than 70 percent of the total wheat production of the country. Despite being an agricultural country, food security of Pakistan has remained at stake since long because of poor yield and high post harvest losses caused by the storage pests. On the other hand country has a great exporting potential not only to achieve Millennium Development Goals (MDGs) relating to food security and safety but can earn foreign exchange and pay off country’s entire debts within 10 years just equaling our yield to that of Indian Punjab. Present investigations were, therefore, carried out to explore these potentials in terms of reducing post-harvest losses, food security and safety risks caused by the storage pests particularly the Khapra beetle which is a notified quarantine pest internationally. The studies revealed an average loss of 15.5 percent when 10 pairs of Khapra larvae were released for a period of 6 months under the natural conditions. Similarly there were found 33 and 8 percent increase in number of weeviled and broken grains, respectively. Besides, the beetle depleted approximately 4 percent carbohydrates that resulted in 0.35 and 1 percent increase in ash and crude fiber contents, respectively. Although total protein and fat percentages were slightly increased, yet these increases were predominantly due to the percentage loss of carbohydrates as well as production of proteinaceous by-products of live insects, insect fragments, and excreta etc., which could not be sieved from the samples before chemical analysis. Further analysis of about 400 samples drawn from the entire province revealed that quality of Punjab wheat not only meets the international standards rather it is superior in many characteristics including protein content, moisture, bulk density, foreign matter, falling number. However, presence of quarantine pests such as T. granarium, Tilletia spores and Striga weeds render it unmarketable in the quality conscious world. A compatible Wheat crop occupies a central position in agriculture sector and our national economy. Pakistan’s contribution toward global wheat production is about 3.2 percent. The Punjab province is leading producer of wheat with a share of more than 70 percent of the total wheat production of the country. Despite being an agricultural country, food security of Pakistan has remained at stake since long because of poor yield and high post harvest losses caused by the storage pests. On the other hand country has a great exporting potential not only to achieve Millennium Development Goals (MDGs) relating to food security and safety but can earn foreign exchange and pay off country’s entire debts within 10 years just equaling our yield to that of Indian Punjab. Present investigations were, therefore, carried out to explore these potentials in terms of reducing post-harvest losses, food security and safety risks caused by the storage pests particularly the Khapra beetle which is a notified quarantine pest internationally. The studies revealed an average loss of 15.5 percent when 10 pairs of Khapra larvae were released for a period of 6 months under the natural conditions. Similarly there were found 33 and 8 percent increase in number of weeviled and broken grains, respectively. Besides, the beetle depleted approximately 4 percent carbohydrates that resulted in 0.35 and 1 percent increase in ash and crude fiber contents, respectively. Although total protein and fat percentages were slightly increased, yet these increases were predominantly due to the percentage loss of carbohydrates as well as production of proteinaceous by-products of live insects, insect fragments, and excreta etc., which could not be sieved from the samples before chemical analysis. Further analysis of about 400 samples drawn from the entire province revealed that quality of Punjab wheat not only meets the international standards rather it is superior in many characteristics including protein content, moisture, bulk density, foreign matter, falling number. However, presence of quarantine pests such as T. granarium, Tilletia spores and Striga weeds render it unmarketable in the quality conscious world. A compatible Wheat crop occupies a central position in agriculture sector and our national economy. Pakistan’s contribution toward global wheat production is about 3.2 percent. The Punjab province is leading producer of wheat with a share of more than 70 percent of the total wheat production of the country. Despite being an agricultural country, food security of Pakistan has remained at stake since long because of poor yield and high post harvest losses caused by the storage pests. On the other hand country has a great exporting potential not only to achieve Millennium Development Goals (MDGs) relating to food security and safety but can earn foreign exchange and pay off country’s entire debts within 10 years just equaling our yield to that of Indian Punjab. Present investigations were, therefore, carried out to explore these potentials in terms of reducing post-harvest losses, food security and safety risks caused by the storage pests particularly the Khapra beetle which is a notified quarantine pest internationally. The studies revealed an average loss of 15.5 percent when 10 pairs of Khapra larvae were released for a period of 6 months under the natural conditions. Similarly there were found 33 and 8 percent increase in number of weeviled and broken grains, respectively. Besides, the beetle depleted approximately 4 percent carbohydrates that resulted in 0.35 and 1 percent increase in ash and crude fiber contents, respectively. Although total protein and fat percentages were slightly increased, yet these increases were predominantly due to the percentage loss of carbohydrates as well as production of proteinaceous by-products of live insects, insect fragments, and excreta etc., which could not be sieved from the samples before chemical analysis. Further analysis of about 400 samples drawn from the entire province revealed that quality of Punjab wheat not only meets the international standards rather it is superior in many characteristics including protein content, moisture, bulk density, foreign matter, falling number. However, presence of quarantine pests such as T. granarium, Tilletia spores and Striga weeds render it unmarketable in the quality conscious world. A compatible treatment of are house with 2 % deltamethrin, Lambda cyhalothrin or DDVP. The present findings will surely help in bridging the gap between food security demand/supply and will enable us to improve quality and safety of the treated cereals resulting in enhanced acceptance of our food crops in the international market." xml:lang="en_US