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Home > A Randomised Controlled Trial Comparing Haemodynamic Stability in Elderly Patients Undergoing Spinal Anaesthesia at L5, S1 Versus Spinal Anaesthesia at L3, 4 at the Aga Khan University Hospital, Nairobi

A Randomised Controlled Trial Comparing Haemodynamic Stability in Elderly Patients Undergoing Spinal Anaesthesia at L5, S1 Versus Spinal Anaesthesia at L3, 4 at the Aga Khan University Hospital, Nairobi

Thesis Info

Author

Mbaya, Karen N.

Department

Anaesthesia (East Africa)

Program

MMed

Institute

Aga Khan University

Institute Type

Private

City

Karachi

Province

Sindh

Country

Pakistan

Thesis Completing Year

2012

Thesis Completion Status

Completed

Subject

Medicine

Language

English

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676728033110

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Background: Spinal anaesthesia is a routinely used anaesthetic technique for elderly patients undergoing operations involving the lower limbs, lower abdomen, pelvis and the perineum. Spinal anaesthesia has several advantages over general anaesthesia and these include stable haemodynamic variables, less blood loss, less post operative pain, faster recovery time and less post operative confusion. However, despite these advantages, the sympathetic blockade induced by spinal anaesthesia can result in hypotension, bradycardia, dysrhythmias and cardiac arrests. Conventionally, spinal anaesthesia is performed at the level of L3,4 interspace; with a reported incidence of hypotension in the elderly ranging between 65% and 69%. A possible strategy for reducing spinal induced hypotension would be to minimize the peak block height to as low as possible for the planned procedure. The purpose of this study was to investigate the decrease in mean arterial pressures and change heart rates from baseline values (haemodynamic stability) of elderly patients undergoing spinal anaesthesia performed at the level of L5, S1 compared to the conventional level at the L3, 4 interspace. Objective: To determine the difference in haemodynamic stability between elderly patients undergoing spinal anaesthesia at L5, S1 interspace compared to elderly patients undergoing spinal anaesthesia at L3, 4. Study design: A randomized single blinded controlled trial Methods: Thirty two elderly patients scheduled for lower limb or pelvic surgery under spinal anaesthesia were randomized into 2 groups (control group and intervention group) using a computer generated table of numbers. Control group; received 2.5 mls 0.5% hyperbaric bupivacaine injected intrathecally at the L3, 4 interspace Intervention group; 2.5mls 0.5% hyperbaric bupivacaine injected intrathecally at the L5, S1 interspace Results: The two groups had similar baseline characteristics in age, sex, body mass index and use of anti-hypertensive medications. There was 68.75% proportion of hypotension in the control group and 75% in the intervention group. The difference was not found to be statistically significant (p= 0.694). During the study period, there were 106 episodes of hypotension, out of which, 65 were in the control group and 41 in the intervention group (p=0.004). This difference was statistically significant.Linear regression analysis of the decrease in mean arterial pressures (MAP) showed a higher decrease in MAP in the control group (p 0.018). There were more crystalloids used in the control group (1006mls ± 374) than in the intervention group (606mls ±211) with a p< 0.0001. There was no difference in the amounts of vasopressors used between the two
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