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Association of 24-32Wk Maternal Triglyceride Levels and Neonatal Birth Weight at the Aga Khan University Hospital

Thesis Info

Author

Omondi, Demetrius Mududa

Department

Obstetrics and Gynaecology (East Africa)

Program

MMed

Institute

Aga Khan University

Institute Type

Private

City

Karachi

Province

Sindh

Country

Pakistan

Thesis Completing Year

2016

Thesis Completion Status

Completed

Subject

Medicine

Language

English

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676728038386

Similar


Introduction: The association of neonatal birth weight and mid-term maternal lipid levels has been demonstrated in several studies with elevated serum triglyceride levels shown to be a strong predictor of the large for gestational age baby/ fetal macrosomia. Maternal diabetes remains the strongest risk factor for developing a LGA/macrosomic baby explained by the Pederson hypothesis. However non-diabetic macrosomia is still an obstetric dilemma with the attendant fetal and maternal complications. This phenomenon could be explained by altered maternal lipid metabolism as lipids have been shown to be important for normal fetal growth and development. Objective: Our primary objective was to determine the association of maternal triglyceride level and neonatal birth weight. Methods: Population: Non-diabetic healthy women with singleton pregnancies between 24-32wks. Design: Prospective cohort study. Outcome of interest: Our primary outcome of interest was neonatal birthweight. Giving birth to a large for gestational age baby was our secondary outcome of interest. Analysis: Pearson correlation coefficient and regression analysis was done to assess association between our variables of interest. Results: We demonstrated a positive linear association between fasting maternal triglyceride levels and neonatal birthweight (r=0.27). Stepwise multiple linear regression demonstrated maternal TG to be an independent predictor of neonatal birthweight (β=164(26-302). In stepwise logistic regression, there was a trend for hypertriglyceridaemia being an independent predictor of birth to a large for gestational age baby though not statistically significant (OR 4.69(0.72-30.59), P=0.106). Conclusions: Fasting maternal triglyceride is associated with neonatal birthweight and is an independent predictor of neonatal birthweight even after adjusting for gestation at delivery and history of macrosomia in healthy non diabetic women. Though not statistically significant there was a trend for maternal hypertriglyceridaemia being a predictor of birth to a large for gestational age baby. Recommendations: A large prospective cohort study based on triglyceride levels should be undertaken to assess the risk of having high TG and delivering a macrosomic/LGA baby.
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100. Al-‘Adiyat/The Chargers

I/We begin by the Blessed Name of Allah

The Immensely Merciful to all, The Infinitely Compassionate to everyone.

100:01
a. By the war-horses, charging, snorting, rushing to the battlefield,

100:02
a. striking sparks with their hooves,

100:03
a. and charging by the dawn,

100:04
a. raising a trail of dust,

100:05
a. and storming into the midst of the enemy troops together.

100:06
a. Indeed, the human being has always been ungrateful and grudging to his Rabb - The Lord,

100:07
a. and truly he is a witness to it,

100:08
a. and he is truly very excessive as well as aggressive in his passion for wealth.

100:09
a. But does he not realize what will happen to him when the contents of the graves are thrown out -

100:10
a. and that which is within the hearts will be made known,

100:11
a. at that Time, their Rabb - The Lord will be Fully Aware of them?

ترجيحات الشيخ ثناء الله بانی بتی في تفسير سورة الفاتحة: دراسة تطبيقية نموذجية

The topic of this research is “Preferences of Qazi Sana Ullah Pani patti in Tafseer of Surah al Fatiha, and these preferences are taken from his famous book of tafseer, named: “Tafseer al Mazhari.  Qazi Sana Ullah Pani Patti is one of the most eminent scholars of Tafseer in sub-continent. He belongs to the progeny of Usman R.A. He was born in PaniPat and got his early education there. Then he travelled to Dehli for higher education of that time. His teachers include: Abdul Raheem al Umari al Dehlvi, Muhammad Abid al Sinami, Sheikh janjan al Dehlvi. Among his famous books are followings: Al Tafseer al Mazhari, Mabsoot, Al saif al Maslool, Irshad ul Talibeen, Tazkira tul Mota, Haqeeqa tul Islam, and many other books. In this research I will discuss preferences of Qazi Sana Ullah with reference to two major types of Tafeer i.e Tafseer bil riwayyah (narration) and Tafseer bil dirayyah (sound reasoning).  

Forgery Detection in Digital Images Using Computational Intelligence

Due to availability of powerful image editing tools images are open to several manipulations. Therefore, their authenticity is becoming questionable especially when images have influential power, for example in a court of law, news reports, insurance claims, criminal investigation, medical imaging etc. The most common image tampering often for malicious purposes is to copy a region and paste to hide some other region of the same image is known as copy-move forgery (CMF). As both regions usually have same texture properties, therefore, this artifact is invisible for the viewers and credibility of the image becomes questionable in proof centered applications. Hence, means are required to validate the integrity of the image and identify the tampered regions. Image forensic techniques determine the integrity of the images by applying various high-tech mechanisms developed in the literature. In this dissertation, three techniques for copy-move forgery detection (CMFD) are presented to verify the truthfulness of image contents. Thus, for efficient detection of CMF, the first approach that we have presented exploits local binary pattern variance (LBPV) over the low approximation components of the stationary wavelets. The proposed CMFD method is applied over the circular regions to address the possible post-processing operations in a better way. The proposed method is evaluated on CoMoFoD (Copy Move Forgery Detection) and KLTCI (kodak lossless true color image) datasets in the presence of translation, flipping, blurring, rotation, scaling, color reduction, brightness change and multiple forged regions in an image. Our second method, presents an algorithm that utilizes stationary wavelet transform (SWT). The method exploits low approximation sub-band for forgery detection. The algorithm divides the low approximation sub-band into the small overlapping square blocks. A reduced feature vector representation is achieved by dividing each block into four triangles. The experimental results demonstrate that the algorithm is capable of detecting duplicated blocks precisely and identify multiple CMF effectively, even when the images are contaminated by blurring and noise. In our third method of CMFD, images are first divided into overlapping square blocks and DCT components are adopted as the block representations. Due to the high dimensional nature of the feature space, Gaussian radial basis function (RBF) kernel principal component analysis (PCA) is applied to achieve the reduced dimensional feature vector representation that also improved the efficiency during the feature matching step. Extensive experiments are performed on DVMM image forensic dataset and google images to evaluate the proposed method in comparison against state-of-the-arts. The experimental results reveal that the proposed technique precisely determines the CMF even when the images are contaminated with blurring, noise, compression and can effectively detect multiple CMF. All the three techniques presented in this dissertation are compared against renounced methods of CMFD over multiple image forensic datasets. The evaluation reveals the prominence of the presented methods as compared to state-of-the-arts. Consequently, the proposed techniques can reliably be applied to detect the forged regions and the benefits can be obtained in journalism, law enforcement, judiciary, and other proof critical domains.