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Home > Association of Tissue Vitamin D Receptor Expression With Breast Cancer Molecular Subtypes in Kenyan Women

Association of Tissue Vitamin D Receptor Expression With Breast Cancer Molecular Subtypes in Kenyan Women

Thesis Info

Author

Kimondo, Mutambuki

Department

Pathology (East Africa)

Program

MMed

Institute

Aga Khan University

Institute Type

Private

City

Karachi

Province

Sindh

Country

Pakistan

Thesis Completing Year

2018

Thesis Completion Status

Completed

Subject

Medicine

Language

English

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676728038484

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Background: Previous studies have shown that reduced vitamin D receptor expression in breast cancer tissue is associated with worse disease outcomes. Furthermore, studies show that estrogen negative and triple negative breast cancer is associated with a poor prognosis and a low breast tissue vitamin D receptor (VDR) expression. Other studies also report that low serum vitamin D levels are associated with more aggressive breast cancer. Methods: This was a cross-sectional study with both a retrospective and a prospective arm. The retrospective part was nested within a larger study; previously constructed tissue microarray blocks (TMA) blocks were used for analysis of VDR expression. The prospective arm recruited women who underwent a breast biopsy for suspicious breast lesions in whom blood samples for serum vitamin D levels and tumour VDR immunohistochemistry were collected. Questionnaire data on pre-determined patient and tumour characteristics were extracted from the charts. Tissue expression of VDR was analysed on immunohistochemistry and serum vitamin D levels assayed. Results: A total of 214 cases were recruited retrospectively and 24 prospectively. There was a statistically significant difference in the VDR score of the Triple negative breast cancer (TNBC) subtype compared to the other subtypes (p value = 0.047, test = ANOVA: Kruskal Wallis Test). There was a positive correlation of VDR score and tumour size. There was a weak negative correlation between VDR score and human epidermal growth factor receptor 2 (HER 2) but no correlation with ER and PR. There was a positive correlation between serum vitamin D levels and VDR Immunoreactive score (IRS). Conclusions: Our results suggest that low or negative VDR score is a marker of poor prognosis in breast cancer as the expression was low in TNBC. However, high VDR score was not associated with ER or PR expressing tumours. The weak negative correlation with tumour size suggests an association of low VDR expression with aggressive tumour features. A randomized controlled trial exploring the utility of vitamin D supplementation or other VDR ligand analogues in TNBC is recommended. A larger study is recommended to determine if indeed there is a correlation between serum vitamin D levels and VDR expression.
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دکھاں دی پنڈ ہوئی تیار

دُکھّاں دی پنڈ ہوئی تیار
کھول کے ویکھیں اس نوں یار
جیہڑے ہار عشق وچ جاندے
بن دے اوہ پھلاں دے ہار
کر مزدوری داج بناوے
ہر دم پیو نوں ایہو کار
گھر دا کھانا پج دا مینوں
سکی روٹی نال اچار
ہاہ غریب دکھی دی یارو
ہوندی فرشوں عرشوں پار
نویں پاکستان دا نعرہ
ویکھو تیل تے تیل دی دھار
دل دا گھر نہیں وسن دیندا
سپ حرص دا پہلے مار
بھکھ، بیماری غربت اندر
پچھی نہ سجناں نے سار
ویکھ غریب بچے تے بیوہ
کیتا سیٹھاں بند ادھار

المعايير المهنية للإدارة والقيادة المدرسية في بعض الدول الأفريقية وإمكانية الإفادة منها بسلطنة عمان

هدفت الدراسة للتعرف على المعايير المهنية للإدارة والقيادة المدرسية في بعض الدول الأفريقية وإمكانية الإفادة منها بسلطنة عمان، واتبعت الدراسة المنهج الوصفي، كما استخدمت نظرية تحليل المضمون في تحليل الوثائق في جمع البيانات والمعلومات. وتوصلت الدراسة إلى مجموعة من النتائج أهمها: أن معايير الإدارة والقيادة المدرسية في سلطنة عمان تركز على تناول المؤشرات دون تفسير شامل ومُتكامل لتلك المعايير، وأن مؤشرات كل معيار محدودة وقليلة للغاية ولا تٌلبي طموحات تطوير القيادة المدرسية في سلطنة عُمان في ضوء خططها المُستقبلية، وأنها بحاجة إلى معايير مستقلة في المعارف والمهارات والاتجاهات المهنية، كما أنها بحاجة إلى التركيز على المُصطلحات والمفاهيم التربوية والإدارية المُعاصرة مثل: التخطيط الاستراتيجي، والشراكات المجتمعية، وتكنولوجيا المعلومات والاتصالات، ومجتمعات التعلم المهنية، وأخلاقيات مهنة الإدارة المدرسي

Effect of Development Strategies and Project Types on Offshore Software Development Using Agile Paradigm- an Exploratory Study

Goal of this research is to check the feasibility of blending Agile software development methods in offshore software development. We hope that this blend will result in a significant improvement in a software development cycle by benefiting from both worlds. There are many factors which contribute to the success / failure of offshore Agile project development, e.g. development strategy, project type, communication channel, cultural differences, distant locations and project size. This thesis focuses on the effect of development strategy and project types on the offshore software development. In this research, we also report on success rate and suitability of different types of software projects and development strategies using offshore Agile software development. The survey indicates that coding and testing phases of software development are best suited for off shoring in any iteration of discipline-oriented sprint life cycle development. We havefound that maximum success rates for feature-oriented development strategy is obtained by developing general modules of a project at distributed location and critical modules at onshore. The study observed maximum success rate for web-based applications and websites among others offshore developed projects.