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Comparison of Vaginal Microbiota in Women With Spontaneous Preterm Labour Versus Those With Term Labour

Thesis Info

Author

Gulavi, Edgar

Department

Obstetrics and Gynaecology (East Africa)

Program

MMed

Institute

Aga Khan University

Institute Type

Private

City

Karachi

Province

Sindh

Country

Pakistan

Thesis Completing Year

2019

Thesis Completion Status

Completed

Subject

Medicine

Language

English

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676728041938

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Background: Preterm birth presents a challenge on a global scale with a disease burden that is on the rise. It is a leading cause of perinatal morbidity and mortality worldwide with approximately 15 million preterm births every year. Kenya has a 12% preterm birth rate with about 190,000 babies born preterm every year. The female lower genital tract bacterial community plays a vital role in maternal and neonatal health. An association between altered vaginal microbial composition and preterm birth has been demonstrated in previous studies. However, findings in terms of composition and diversity of these bacteria across the few studies available have differed. With the progress and increased availability of using gene sequencing based techniques, the contribution of these vaginal microbial community changes to preterm birth have emerged as an area for research focus. Study Objective: The study objective was to compare the vaginal microbiota of women who presented with spontaneous preterm labour with those with term labour using 16S ribosomal RNA gene sequence-based techniques. Methodology: The study was a case control study set in AKUH Nairobi labour ward. Vaginal swabs were collected from mothers who presented between 26 weeks to 36 weeks of gestational age with diagnosis of preterm labour as well as controls matched for age and parity who presented in labour past 37 weeks of gestation. The vaginal microbiota of women who were in preterm labour was compared to those in term labour using 16S ribosomal RNA (rRNA) gene sequences. Results: In total, 100 participants were recruited for the study with 50 cases of preterm labour and 50 matched controls. Vaginal gene sequencing was done for 46 cases and 19 control with high quality reads achieved from 52 samples. The vaginal microbiota in both study groups was rich in the Lactobacillus genus of organisms. Fourty seven samples (90.4%) had a microbiota rich in different Lactobacillus species including unclassified Lactobacillus (n=35), Lactobacillus. iners (n=23), Lactobacillus. helviticus (n=18), Lactobacillus. vaginalis (n=17), Lactobacillu.mucosae (n=2), Lactobacillus. zeae (n=1) and Lactobacillus. coleohominis (n=1) existing with several overlaps. There was high diversity of the vaginal microbiota although it did not fall into any assigned community state type. Conclusions: This study demonstrates a spectrum of diversity in the vaginal microbiota without clear evidence of any specific microbiota patterns that have a correlation with preterm labour.
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پروفیسر عبدالمنا ن بیدلؔ

عبدالمنان بیدلؔ
پٹنہ یونیورسٹی کے شعبہ فارسی کے سابق پروفیسر جناب عبدالمناف بیدل کی وفات گزشتہ اپریل میں ہوگئی، انھوں نے تقریباً نوے سال کی عمر پائی اور اس لحاظ سے خوش نصیب تھے کہ اپنی زندگی میں اپنے شاگردوں کو علم و ادب میں بڑی شہرت حاصل کرتے دیکھا، بڑے شفیق استاد تھے، اس خاکسار کو بھی ان کی شاگردی کی سعادت نصیب ہوئی، اپنے زمانہ میں فارسی کی نصابی کتابی انگریزی لباس پہن انگریزی زبان میں پڑھاتے وقت اس مشرقی زبان میں مغربی رنگ پیدا کردیتے، بڑے اچھے شاعر بھی تھے، بیدل تخلص کرتے، مشاعروں میں اپنے ترنم سے اپنی شاعری میں دلنوازی، دل ربائی اور دل نشینی کی ساری کیفیت پیدا کردیتے، آخر عمر میں مذہبی رنگ بھی زیادہ غالب ہوگیا تھا، زائرین حج کی خدمت مختلف حیثیتوں سے کرتے رہے، استاذی المحترم حضرت مولانا سید سلیمان ندویؒ کے سفر حج میں ساتھ تھے، سلیمان نمبر میں ان کا ایک پرکیف مضمون ’’سفر حجاز کے تاثرات‘‘ کے عنوان سے شائع ہوا، گزشتہ اگست میں ان کو حکومت ہند کی طرف سے فارسی کی سند کا ایوارڈ بھی ملا، لیکن حکومت کی یہ جوہر شناسی اس وقت ہوئی جب ان کے بہت سے شاگردوں کو ان سے پہلے اس اعزاز سے نوازا جاچکا تھا، اﷲ تبارک و تعالیٰ ان کو ان کی نیکیوں اور خوبیوں کی بدولت کروٹ کروٹ جنت نعیم عطا فرمائیں، آمین۔ (صباح الدین عبدالرحمن، مئی ۱۹۸۲ء)

World View: A Philosophical and Theological Perspective

The world of today has emerged as a global village with diversity of culture, faith, religion, ideology and belief. The difference of point of view and intolerance are still left to be taken into account by the intellectuals of the world seriously with other multiple universal problems. In the present scenario, there is a need to rationalize the human existence on the face of Earth in terms of the sole objectives of human life. This study is an attempt to present a world view to the humanity through a philosophical and theological approach. Multiple questions have been raised and then answered with reference to Islamic religious philosophy of human life. It is an attempt to strengthen harmony among the world citizens.

Best Proximity Point Results in Fuzzy Metric Spaces

The aim of this research is to investigate some contractions and establish the existence results of single and multivalued mappings in frame work of some abstract space. Banach (1922) presented a fixed point theorem, namely Banach contraction theorem, which states that, a contraction mapping has a unique fixed point in a complete metric space. This theorem is widely applicable in proving the existence of solutions of functional equations under certain conditions. This theorem is based upon the iterative process, so it can be easily implemented on computer. This theorem was a revolution in fixed point theory. Later on , several generalizations of this theorem have been obtained. Fixed point results are widely studied in the framework of topological, metric and ordered oriented spaces. It is interesting to study that a nonlinear functional equation T(x) = x (where T is some linear or nonlinear operator defined on metric or fuzzy metric space) has either a solution or possess no solution. If the nonlinear functional equation has any solution, then it is interesting to find some algorithms which lead to an appropriate solution, but if nonlinear functional equation has no solution, then to try and find some approximate solution. The approximation, optimization and fixed point theory incorporate the main theme of nonlinear analysis. The best approximation theory is applicable in variety of problems arising in nonlinear functional analysis. Banach (1922) fixed point theorem is vastly applicable in proving the existence of solutions of functional equations under certain conditions. Many authors generalized Banach contraction principle in various directions. To address the question, if a nonlinear functional equation has no solution, it is recommended to approximate the solution which solves the optimization problem such that d(x, T x) is minimum. Ky Fan’s (Fan (1969)) best approximation result has been used when some nonlinear functional equations have no solution. In this thesis, best proximity point results in non-Archimedean fuzzy metric space are proved and some optimal best proximity point results are also obtained. These results provides the existence of optimal approximate solutions to some equations which have no solution. Further, fuzzy optimal coincidence point results for different proximal contractions in the framework of complete non-Archimedean fuzzy metric space are obtained. These results also holds in fuzzy metric spaces when some mild assumptions are added in the domain of involved mappings. In the next part of thesis, best proximity point results in a complete non-Archimedean fuzzy metric space with ordered structure have been discussed. Further, a class of multivalued mappings is introduced which satisfies Suzuki type generalized contractive condition in the framework of fuzzy metric spaces and some fixed point results are obtained for such kind of mappings. In next part of this thesis, Suzuki type contraction conditions are further generalized as Suzuki type F−contraction fuzzy mapping in ordered metric spaces. As an application, a common fixed point result for hybrid pair of single and multivalued mappings, the existence and uniqueness of common bounded solution of functional equations arising in dynamic programming are obtained. The obtained results generalize and extend various results in the existing literature. In each chapter, some examples are provided, which shows the validity of the results along with couple of remarks about the comparison of obtained results with the existing ones in the literature.