Brief background: Image compression has been widely accepted as the solution to the explosion of imaging data since the advent of multiaxial multisequence imaging. However, compromise on diagnostic quality secondary to this modification has been an issue. Many studies have been carried out looking at just noticeable differences but few have been undertaken to look at the difference in ability to detect pathology in original versus cineloop compressed images. This study was done to compare lesion detection ability of cineloop compressed images as compared to original images.
Objectives: A comparative study to evaluate detection of brain lesions in wavelet compressed Audio video Interleave (AVI) cineloop re-formatted MRI images as compared to originally acquired 16 bit digital MRI images.
Methods: This was a prospective comparative study. MRI brain images of consecutive non-selected patients referred for MRI brain examinations were compressed by means of a wavelet algorithm at ratios of 30:1(70%) and then converted into Microsoft AVI cine loop format using Image J freeware( Appendix 3).
All the sequences and all the sections of a particular examination (original and reformatted images) were reviewed on the same high resolution computer monitor by two independent reviewers (Appendix 2).
Analysis: Each of the observers captured their findings in a pre-defined form then comparison of lesion detection was done taking the original images as a gold standard. Sensitivity were calculated for evaluation of number of lesions, location of lesions, signal characteristics and image quality. As compared to the original brain MRI images the sensitivities in the cineloop compressed images for presence of lesions was 100%, Number of lesions present was 100%, location of largest lesion was 97%, T1 signal was 96%, T2 signal was 96%, GRE signal was 95%, FLAIR signal was 93%, Presence of restricted diffusion was 98%, post contrast enhancement was 98%, and edema surrounding lesion was 100%. There was reduction of subjective image quality with 79% of the compressed cineloop images scoring 1 less point than the original images.
Outcomes: This study proves cineloop compressed images at a a ratio of 1:30 do not reduce ability to detect lesions in terms of size, number, locations and signals. Despite reduced quality of images, the diagnosis remains largely unchanged. Hence, image compression can be applied to MRI Brain imaging for interpretation allowing ease of teleradiology, reduced storage costs and increased transmission speeds.
منشی محمد احتشام علی کاکوروی لکھنؤ کی سرزمین میں اپریل کے چوتھے ہفتہ میں ایک اور حادثہ پیش آیا یعنی کاکوری کے ممتاز خاندان کے رئیس جناب منشی محمد احتشام علی صاحب نے ۲۲؍ اپریل کی صبح کو ۷۵ برس کی عمر میں وفات پائی، کہنا چاہئے کہ اودھ میں قدیم شریفانہ جوہر وضعداری، دینداری، مروت، سیرچشمی، غربا نوازی اور مسکین پروری کا یہ اخیر نمونہ تھا، ان کی پوری زندگی میں جس میں وسعت کا زمانہ بھی تھا اور تنگی کا بھی، ان کے ہاتھ یکساں کھلے رہے اور اس اخفاء کے ساتھ کہ بائیں ہاتھ کو بھی داہنے ہاتھ کی خبر نہ تھی، وہ مولانا شاہ فضل رحمان صاحب گنج مراد آبادی سے بیعت تھے، اس تعلق کو اخیر اخیر وقت تک جس طرح نباہا، وہ ان کی سعادت مندی کا نشان ہے، پابندی یہ کہ مرتے وقت سجدہ عبودیت ادا کیا ہے اور صبر و شکر کے کلمے زبان سے نکلتے رہے۔ ان کی جوانی تھی کہ ندوۃ العلماء کا غلغلہ بلند ہوا، چونکہ اس مجلس کے سرپر فضل رحمانی سایہ فگن تھا۔ اس لئے حضرت شیخ کے سارے حلقہ بگوش اس کے حلقہ میں تھے اور اسی مناسبت سے جناب منشی محمد اطہر علی صاحب مرحوم اور ان کے ساتھ میں جناب منشی احتشام علی صاحب ندوہ کے خدام میں داخل ہوئے تھے، اپریل ۱۸۹۵ء میں اس کا پہلا جلسہ لکھنؤ میں ہوا تھا، اس اپریل ۱۸۹۵ء سے لے کر ۲۲؍ اپریل ۱۹۴۳ء کی صبح تک جب کہ انہوں نے زندگی کی اخیر سانس لی ہے، یکساں دلچسپی خلوص و انہماک سے اپنے فرائض کو انجام دیا ہے۔ نہ صرف رئیسوں میں بلکہ مسلمانوں میں اس قدامت خدمت اور مخلصانہ مذہبی خدمت گزاری کی مثال شائد ہی ملے۔ خیالی گنج میں ان کی بڑی اور وسیع کوٹھی، ان کے عزیزوں کا...
The establishment and implementation of justice is the primary responsibility of the Islamic state. In every Islamic society, the establishment of the systems of justice and police become an obligation and a necessity for the betterment of society and for the solution of the problems faced. The present research deals with the issue of Islamic system of judiciary highlighting its various components in the light of Shari‘ah. Oath, Evidence, Witness and various technical terms used in the dissemination of Ajustice are explained with evidences from Qur’┐n and Sunnah of the Holy Prophet (S.A.W). So this research concludes with the note that if the system of justice be strengthened; all the problems, in particular elimination of crimes can take place, and decisions can be given in the light of the laws and orders in the light of the Shari‘ah.
The exploration of genetically variable accessions is the key source of germplasm conservation and potential breeding material for the future. The more diverse group of cultivars can provide an ample opportunity to breeders for releasing new and superior varieties, considering their quality traits for direct commercial utilization. In advanced research studies the polymerase chain reaction (PCR) based molecular markers have a great contribution in genome analysis and marker-assisted selection. In this study, the genetic diversity of Cicer arietinum L. twenty four indigenous and forty six exotic accessions were assessed, obtained from plant genetic resource institute (PGRI), national agriculture research centre, Islamabad, Pakistan. These accessions were planted under field conditions at research area of University of Malakand, Chakdara, Khyber Pakhtunkhwa. The genetic diversity among seventy chickpea indigenous and exotic accessions was estimated using morphological, biochemical; sodium dodecyle sulphate polyachryl amide gel elecctrophoresis (SDS-PAGE) and molecular markers; random amplified polymorphic DNA (RAPD) and simple sequence repeat (SSR) markers. Based on qualitative and quantitative morphological traits, the average coefficient of variation (%) was calculated 44.8% and 56.8% respectively with significant correlation among yield traits. The analysis revealed that the accessions 1898, 2819, 3022, 3037, 3040, 3043, 3054, 3059 and 3063 were best in performance with a total of 12% environmental error. The statistical analysis showed that 100 seeds weight was significantly correlated with seed size quantitatively. The majority of accessions of USA origin were observed with maximum100 seed weight (30-57gm) and medium to large (7.2- 9.9mm) size seeds including one of the Pakistani accession 2562 also with large size seeds. The wilt incidence (%) was observed to be comparatively higher (30 - 42.85% ) at both growth stages in field screening of the germplasm than that of greenhouse conditions; reduced up to 8.57% at seedling stage and 24.28% at reproductive stage. The t-test however, indicated that chickpea both from indigenous and exotic origin showed a significant variation at alpha ≤ 0.050 at seedling and reproductive stage. The cluster analysis based on protein data indicated 50% genetic diversity among the accessions. The clustering pattern did not reveal any grouping that could be attributed to either the geographic distribution or the field performance. For molecular characterization of xiv germplasm twenty random amplified polymorphic DNA (RAPD) and twenty simple sequence repeat (SSR) polymerase chain reaction (PCR) based markers were screened for estimation of genetic variability. In the markers, five random amplified polymorphic DNA (RAPD) and fifteen simple sequence repeat (SSR) were polymorphic and showed significant level of coefficient of variation. The data of molecular markers were scored by the presence (1) and absence (0) of allele and subjected to statistical analysis. The analysis was based on coefficient of molecular similarity using un-weighted pairs group mean average (UPGMA) resulted in 37% and 55% genetic diversity among the total germplasm using random amplified polymorphic DNA (RAPD) and simple sequence repeat (SSR) markers respectively. For marker trait association analysis, twenty random amplified polymorphic DNA (RAPD) and twenty simple sequence repeat (SSR) makers were utilized to find correlation of markers with yield contributing components and chickpea Fusarium wilt resistant genes. None of the random amplified polymorphic DNA (RAPD) primers were linked to seed size and seed weight while, simple sequence repeat (SSR) markers TA72 and TA130 showed association at linkage distance 0.4 with seed weight and seed size. Based on which the high yielding accessions among chickpea germplasm were identified. Hence, the association of these makers is helpful for the plant breeders to select lines on the basis of yield contributing traits. Among the total used random amplified polymorphic DNA (RAPD) and simple sequence repeat (SSR) primers, TA194 (SSR marker) was linked to the disease response with 85% probability level. This association or correlation of the marker was reconfirmed by receiver operating characteristic curve (ROC). Hence, the use of the sorted wilt resistant genotypes through simple sequence repeat (SSR) marker TA194 can make available ample prospect in marker assisted breeding for yield improvement of chickpea in Pakistan.