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Home > Comparison of Weight Adjusted Dose Versus Fixed Dose Ondansetron in Preventing Shivering Following Spinal Anesthesia for Cesarean Deliveries

Comparison of Weight Adjusted Dose Versus Fixed Dose Ondansetron in Preventing Shivering Following Spinal Anesthesia for Cesarean Deliveries

Thesis Info

Author

Gicheru, Moses Kimuri

Department

Anaesthesiology (East Africa)

Program

MMed

Institute

Aga Khan University

Institute Type

Private

City

Karachi

Province

Sindh

Country

Pakistan

Thesis Completing Year

2016

Thesis Completion Status

Completed

Subject

Medicine

Language

English

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676728042184

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Background: Spinal anesthesia is an effective regional anesthesia technique, which is preferred in almost 86% of cesarean sections in the United States and United Kingdom. Eighty percent of cesarean sections done at the Aga Khan University hospital are under spinal anesthesia. Shivering is a common complication of spinal anesthesia, it occurs in 40%-64% of patients after neuraxial anesthesia. Shivering may cause maternal and fetal hypoxemia, maternal discomfort and a problem to the anesthesiologists when it comes to monitoring the patient during cesarean sections. Ondansetron a 5-HT3 receptor antagonist is effective in treatment and prevention of post spinal anesthesia shivering. In published studies use of a fixed dose in patients with different weights, masked the dose effect ondansetron in preventing shivering. Such that not adjusting the dose according to the weight of patients’ resulted in a higher occurrence of shivering. No study compares different doses of ondansetron in preventing shivering in parturient women who have had spinal anesthesia for cesarean section. Objectives: To determine if a weight-adjusted dose is better than a fixed dose of ondansetron in preventing shivering following spinal anesthesia for cesarean delivery. Study design: Double blinded Randomized Controlled Trial. Method: This is a randomized, double-blinded controlled trial of 124 women scheduled for elective cesarean surgery. The Women were randomized into two equal groups. The intervention group received intravenous ondansetron weight adjusted dosing at 0.1mg/kg and the control group received a fixed dose of 4mg before spinal anesthesia. The occurrence and severity of shivering and other outcomes, such as headache, pruritus were assessed and recorded during the surgery and postoperative period. Results: A total of 124 patients were included in the study. Social demographic data and baseline vital signs did not differ significantly between the groups. Shivering was observed in 14 patients (22.6%) in the control group that received 4mg ondansetron and 7 patients (11.3%) in the intervention group that had 0.1mg/kg of ondansetron, but there was no statistical difference between the groups (p- value 0.090). The severity of shivering was greater in the control group compared to intervention group where patients who developed grade two shivering were 8.1% to 0% respectively. (P value 0.047). There was no difference in the occurrence of pruritus between the two groups. No patient developed a headache or required treatment for very severe shivering. Conclusion: This study, found that Ondansetron weight adjusted dose at 0.1mg/kg, reduced the severity of shivering when compared to
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المبحث الرابع: أهم الشاعرات في اللغة الأردية بعد قيام باكستان

المبحث الرابع: أهم الشاعرات في اللغة الأردية بعد قيام باكستان

 من أھم الشاعرات بعد التوحید لھن الدور الکبیر في إصلاح المجتمع ومنھن۔

صفية شميم مليح آبادي

 وھي من أکبر الشاعرات ویأتي إسمھا في الصف الأول في مقدمۃ الشاعرات المشھورات وقد ولدت في 28 مارس 1920م ولھا مجموعات شعریۃ رائعۃ منھا نغمۃ قدس، چراغ، نشاط غم وگرائیہ ستم وغیرھا۔

رابعة نهاں

 ولدت في 20 سبتمبر في عام 1920م، وھي شاعرۃ قدیمۃ ومعروفۃ ولھا خمس مجموعات شعریۃ وھي شقیقۃ الشاعرۃ۔ الکبیرۃ بلقیس جمال. ومن أشعار رابعہ نھاں:

دل و نگاہ کے ہر امتحاں سے گزرے ہیں

خموش رہ کے بھی حسن بیاں سے گزرے ہیں

الترجمۃ:
 لقد مررنا من کل امتحان القلب والنظر

 فقد قُمنا بحسن البیان مع السکوت الدائم

آدا جعفري

 ولدت الشاعرۃ ادا جعفري 1924م وقد ثم طبع مجموعتھا الشعریۃ الأولی في عام 1950م۔ ولھا أشعار مشھورۃ ومعروفۃ منھا:

تم پاس نہیں ہو تو عجب حال ہے دل کا

یوں جیسے میں کچھ رکھ کے کہیں بھول گئی ہوں

الترجمۃ:
 لم تکن أنت موجودٌ عندي وحالۃ قلبي عجیبٌ

 ھکذا کأنني وضعتُ شیءًا ثم نسیتُہ

 ومن الشاعرات المعروفات زھرہ نکاہ   کشور ناھید وفھمیدہ ریاض

فهميدة رياض

 وھي من أشھر شاعرات العصر الحدیث تناولت في أشعارھا المواضیع المختلفۃ ورفعت قلمھا وصوتھا ضد الظلم والاستبداد السیاسي ولھا مجموعات شعریۃ رائعۃ ومنھا پتھر کی زبان، بدن دریدہ، دھوپ، ادھورا آدمی وغیرھا من الکتب الرائعۃ والمنظومات القیمۃ ولھا أشعار رائعۃ منھا:

خدائے ہر...

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A Study of the Access for Girl Students to Science Group at the Secondary Level

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