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Home > Expression Patterns of P53 and Her2/Neu in Primary Ovarian Carcinomas

Expression Patterns of P53 and Her2/Neu in Primary Ovarian Carcinomas

Thesis Info

Author

Mutuiri, Anderson Peter

Department

Pathology (East Africa)

Program

MMed

Institute

Aga Khan University

Institute Type

Private

City

Karachi

Province

Sindh

Country

Pakistan

Thesis Completing Year

2012

Thesis Completion Status

Completed

Subject

Medicine

Language

English

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676728051356

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Background: Ovarian tumours are common neoplasms of the female genital tract and a leading cause of cancer mortality among women. There is paucity of local Kenyan data on the morphologic subtypes of ovarian tumours and the expression of select prognostic markers in ovarian carcinomas has not been previously investigated. The aim of this study was to determine the frequency and describe the patterns of p53 and HER2/neu expression in primary ovarian carcinomas and to describe the clinical and pathologic features of ovarian tumours diagnosed at the Pathology Laboratory of the Aga Khan University Hospital Nairobi. Methodology: A cross-sectional descriptive study was undertaken. Electronic histopathology reports of all ovarian tumours diagnosed over a three year period in the Histopathology department at the Aga Khan University Hospital Nairobi Laboratory were retrieved. Clinical and pathologic data were recorded. Haematoxylin-eosin stained slides of the ovarian carcinomas were reviewed and appropriate paraffin-embedded blocks selected and retrieved from the archives for immunohistochemistry. Additional paraffin blocks of primary ovarian carcinomas diagnosed consecutively over a 2 year period from the Aga Khan Hospital Kisumu, and the AICKijabeHospital were included in the study after review of haematoxylin-eosin stained slides. Sections were cut from all the selected ovarian carcinoma blocks and stained for HER2/neu and p53 using standard immunohistochemical techniques. The data were analyzed using SPSS version 17 and are presented in tables and charts. Results: Three-hundred and seventy-four ovarian tumours were diagnosed at Aga Khan University Hospital Nairobi during the study period. The median age for malignant tumours was 51.1 years. The most common benign tumour was mature cystic teratoma (44.3% 95%CI ±5.68%). The most common malignant tumour was serous carcinoma (44.7% 95%CI ±11.43%). Forty-three point three percent (95%CI 32.1-55.2%) of carcinomas were positive for p53 and 13.4% (95%CI 7.2-23.6%) were positive for HER2/neu. Serous carcinoma (61.1% 95%CI±15.9%) and adenocarcinoma, not otherwise specified (33.3% 95%CI ±11.3%) were more likely to be positive for p53. There was no association noted between the histologic grade or pathologic stage and positivity for p53. There was no association noted between staining for HER2/neu and histologic type, histologic grade or pathologic stage of carcinoma. Conclusion: The proportion of histologic subtypes of primary ovarian tumours that were diagnosed is similar that described in literature. There is no significant difference in the expression patterns of both p53 and HER2/neu from that described in literature.
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محمد امین مسعود صدیقی

محمد امین مسعود صدیقی
(ریاض الرحمن شروانی)
حبیب منزل، میرس روڈ، علی گڑھ،
۲۰۰۱-۳-۲۷ء۔
مکرمی و محترمی! السلام علیکم ورحمۃ اﷲ،
لکھنؤ سے کل ۲۵؍ مارچ کا ’’جدید مرکز‘‘ آیا تو اس میں محمد امین مسعود صدیقی صاحب کی اچانک وفات کی خبر پڑھ کر دلی صدمہ ہوا، اخبار میں اس خبر کی سرخی ’’مولانا آزادؒ کے عاشق تھے مسعود صدیقی‘‘ چھپی ہے اور اس سے بہتر سرخی کوئی اور نہیں ہوسکتی تھی۔ کیا عجیب عشق تھا کہ چاہتے تھے ہر فرد، ہر اخبار اور رسالہ اور ہر ادارہ اس عشق میں ان کا شریک ہوجائے۔ ہر ممکن طریقے سے مولانا آزادؒ کے پیغام کی اشاعت کے لئے سرگرداں رہتے تھے۔
ان میں اور بھی بہت سی خوبیاں تھیں، بہت دین دار، مخلص، متحرک اور بے نفس انسان تھے، میرا بہت لحاظ کرتے تھے۔ میں کسی معاملے میں ان سے اختلاف کرتا تھا تو خاموش ہوجاتے تھے، کبھی بحث نہیں کرتے تھے۔ مولانا آزادؒ پر کہیں کوئی چیز ان کی نظر سے گزرتی تھی تو اس کی فوٹو کاپی مجھے بھیج دیتے تھے۔ میں لکھنؤ جاتا تو انہیں مطلع کردیتا اور میرا جہاں کہیں قیام ہوتا وہ وہاں آکر مجھ سے ضرور ملتے تھے۔ مجھے ان کا آخری خط جو ۲۵؍ فروری کا لکھا ہوا تھا، ۲۸؍ کو ملا تھا۔ اس میں انہوں نے لکھا تھا: ’’معارف کا فروری ۲۰۰۱؁ء کا شمارہ آپ کو مل گیا ہوگا۔ اس میں اس ناچیز کا ایک مراسلہ شائع ہوا ہے۔ اس مراسلے پر حواشی میں جو باتیں تحریر فرمائی گئی ہیں۔ اس (کذا) سے نفس کی اصلاح کا موقع ملا ہے‘‘۔ ملاحظہ فرمایا آپ نے کس طرح اپنی کوتاہی کا اعتراف کیا ہے۔ میں نے کچھ غلط تو نہیں لکھا کہ کیسے بے نفس انسان تھے۔ اﷲ تعالیٰ مغفرت فرمائے اور درجات بلند کرے۔ بہت جلدی چلے گئے۔
امید ہے...

یورپ میں قرآن کریم کی طباعت اور تراجم کے مختلف ادوار

After Second World War, when the distances between the East and the West began to reduce and the west paid attention to the eastern knowledge seriously. Especially European countries took interests in Islamic subjects and a new trend was generated which is known as Orientalism and the people who acquire the subjective knowledge are being called orientalists. In this connection the orientalists started shown keen interest in learning Islamic subjects and with that interest their object was not to spread the religion Islam but to negate and cancel the true picture of true religion Islam, fear of dominancy of Islam, spread of Christianity and multiple political nations. That is why the first thing they have targeted was the Holy Quran. While X-Prime minister William Evart Gladstone quoted 1882 ''Till the Quran exists, it is impossible for Europe to down the East''. Since then the new era of publication and translations of Quran took place, in which era the treatise and conversion made in various languages differently in different countries which will be discussed in this research article along with the discussion of orientalists who took part in the compositionor translation.  

Cognitive Radio Based Smart Grid Communication System

Smart grid (SG) concepts have revolutionized the future of conventional electric grid by making it more efficient, resilient and reliable using state-of-the-art technologies, modern equipment, and automation control systems. However, the full realization of all the above-mentioned benefits is not possible without the implementation of a fast, reliable and economical communication network that must exhibit spectral and energy efficiency. Additionally, the data generated by various SG applications is not only in enormous proportion but also diverse in nature in terms of its delay tolerance. The crucial need to transmit a significant amount of smart grid applications data in a spectral efficient manner makes cognitive radio (CR) technology most suitable for SG environment. Identically, TV white spaces (TVWS) is the most expectant candidate for CR based smart grid communication network (CRSGCN). Using CR in SGCN will bring its own set of communication problems. There is not much of a research available for problems associated with CRSGCN and primarily, this is the motivation behind this research work. This dissertation addresses some critical challenges in the design of CRSGCN. The research work can be divided into two parts. First, we present a comprehensive survey to establish the diverse communication requirements for three subsets of SGCN: Home Area Network (HAN), Neighborhood Area Network (NAN) and Wide Area Network (WAN). Then, we review SG applications to analyze what kind of data is suitable to be carried over CR technology. Based on these requirements, we propose a CR based end-to-end network architecture for SGCN by using IEEE communication standards suitable for delay-tolerant data such as required by automatic metering infrastructure (AMI) and demand response (DR) etc. Then, we identify salient features of the proposed network architecture that makes it a viable solution along with some open issues and challenges, related to CRSGCN. The second part is then dedicated to address resource allocation in CRSGCN, in particular, the two most important researched areas related to CR, i.e., channel allocation (CA) and power allocation (PA). We modeled a communication scenario based on CRSGCN architecture proposed in part one, by dividing the service area into groups of secondary users (SUs) called NAN clusters, depending upon the distance of Smart Meters (SMs) from Data Concentrator Unit (DCU). Then, we formulated a multiple constraint NP-hard CA problem using interference avoidance strategy by considering two practical scenarios: fairness-based allocation and priority-based allocation. We then propose our CA algorithm based on Cat Swarm Optimization (CSO) to eliminate the severe integer constraints of the problem under consideration. Next, for the same NAN communication scenario using IEEE 802.11af standard via open loop regulatory framework for TVWS, we formulate a joint power and channel allocation (JPCA) problem. Next, we present an efficient PA scheme, meeting quality-of-service (QoS) requirements, followed by CA scheme based on cuckoo search algorithm (CSA). The performance of the proposed solutions is analyzed using exhaustive simulations to optimize power consumption, fairness and user rewards. The presented results in the form of graphs and numerical comparisons indicate the effectiveness of our allocation algorithm to achieve the desired objectives. We have investigated and formulated a JPCA problem with multiple constraints considering two practical cases of fairness-based allocation and priority-based allocation in an SG environment in an innovative way, which perhaps is among pioneer and premiere works in its technical domain. We hope, this work will be regarded as a corner stone in CRSGCN and will pave way for more future studies in this domain.