Search or add a thesis

Advanced Search (Beta)
Home > Immunohistochemical P21 Expression in Breast Cancer: Association With Patient and Tumour Characteristics

Immunohistochemical P21 Expression in Breast Cancer: Association With Patient and Tumour Characteristics

Thesis Info

Author

Njihia, Benjamin N.

Department

General Surgery (East Africa)

Program

MMed

Institute

Aga Khan University

Institute Type

Private

City

Karachi

Province

Sindh

Country

Pakistan

Thesis Completing Year

2017

Thesis Completion Status

Completed

Subject

Medicine

Language

English

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676728053684

Similar


Introduction: Molecular characterisation of the breast cancer has allowed for targeted therapies that are improving outcomes. The gains achieved by these treatments have fuelled the search for other targets, including cyclin-dependent kinase inhibitors such as p21. p21 expression in breast cancer has been shown to be variably associated with clinical and pathological parameters in different populations. It is possible that either methodological or biological differences underlie these variations. Objective: The current study sought to determine the association of p21 expression and clinico-pathological parameters in breast cancer patients at the Aga Khan University Hospital in Nairobi, Kenya. Methods: Clinically annotated tissue samples were obtained in a consecutive fashion. Specimen were immunohistochemically stained for p21 expression with clinicopathological data extracted for corresponding cases. p21 expression was assessed against age, parity, menopausal status, body mass index, hormonal receptor status, tumour size and grade. Distribution of mean p21 score was assessed for normality and data were analysed using Kruskall-Wallis test, chi-square and Fisher's exact test at an alpha level of 0.05. They were presented in form of tables, charts and photomicrographs. Results: Ninety-eight cases were included in the study. Mean age was 47.55 years with mean parity 2.96 live births. A slight majority of patients were pre-menopausal (56.3% versus 42.5%). Average body-mass index was 29.69 kilograms per square metre. Majority of patients had invasive ductal carcinoma (87.6%) that was moderate-to-high grade (92.7%), 2 centimetres or larger (95%), with lymphovascular invasion (70.4%), and vi hormone-receptor positive. Mean expression of p21 at 1:100 dilution was approximately 20% was statistically significant with tumour size. Conclusion: The findings of the current study demonstrate a possible association of p21 expression with tumour size. The demonstration of a trend towards p21 loss with increasing body mass index may benefit from exploration with a larger dataset.
Loading...
Loading...

Similar Books

Loading...

Similar Chapters

Loading...

Similar News

Loading...

Similar Articles

Loading...

Similar Article Headings

Loading...

۴۸۔ تنہائی

تنہائی

ہائے!یہ جسم و جاں کو کاٹتی ہوئی پر اسرار خاموشی

وہ راتوں کو جگانے والے کیا ہوئے

آنکھوں کی پتلیوں میں نیند چبھ رہی ہے

وہ داستان سنانے والے کیا ہوئے

ہر لمحہ تنہائی ڈسے جارہی ہے

وہ عہد و پیماں نبھانے والے کیا ہوئے

Islam and Society: Role of the Departments of Islamic Studies, an Analytical Study

This study elaborates the connection between Islam and society and the role of Islam in the formulation and reformation of a society. This research highlights the need and the significance of the concept of developing a linkage between the religious and otherwise classes of society. The study primarily focuses on the role and the influence of the departments of Islamic studies in Pakistani universities in defusing tensions and promoting peace and hormony among various classes of society. The study includes an analysis of the visions, mission statements and the objectives of the various departments of Islamic studies in leading universities of the country. The article highlights the system of education in Islam and the problems in the system of education of Pakistan which play a part in the role of the departments of Islamic studies. The research also focuses on the role of the students and the teachers of the departments of Islamic studies in the light of Islamic teachings.

Impact of Corporate Governance and Corporate Social Responsibility on Firms Performance: A Moderating Role of Corporate Philanthropy

The paper examines the effect of Corporate Governance and Corporate Social Responsibility on firm’s performance in the listed companies of Pakistan Stock Exchange in the presence of Corporate Philanthropy. The study employs yearly data spanning over the period of 2004 to 2017. Variables such as Corporate Governance, Corporate Social Responsibility and Firm Specific Variables serve as independent variables, Corporate Philanthropy as a moderating variable and firm’s performance proxies by Earning Yield, Tobin’s Q, Return on Assets and Return on Equity as dependent variables in the model. Data has been extracted from Annual reports of the firms, Security &Exchange Commission of Pakistan, Pakistan Stock Exchange and Pakistan Center of Philanthropy. Results deduced that Corporate Governance and Corporate Social Responsibility have significant effect on firm’s performance. The data has been analyzed with a view to check cause and effect relationship by using Multivariate Panel Data Analysis. Generalized Method of Movement (GMM) / Dynamic Panel Method (DPM) method is used to ensure that there are no issues of Reverse Causality, Feedback affect, Endogeneity and Simultaneity. Firm Age, Leverage, Board Independence, CEO Duality, Miscellaneous Project of Social Responsibility, Cash Donation, Earthquake and Natural Disaster have negative impact on firm’s performance i.e. Earning Yield, Tobin’s Q, Return on Assets and Return on Equity. However, Firm Size, Education Sector, Infrastructure Development, Charity in shape of material and Miscellaneous Project of Philanthropy have positive impact on firm’s performance. Mixed results were found in case of Board Size and Corporate Social Responsibility. While considering the Earning Yield and Return on Assets as a firm’s performance, Board Size has negative and Corporate Social Responsibility has positive impact on Earning Yield and Return on Assets. The role of Corporate Philanthropy as moderator between Corporate Governance and firm’s performance is also significant. Corporate Philanthropy represents negative significant moderating effect in relation with Firm Age, Firm Size and Leverage; moreover, it has positive significant moderating effect in relation to Board Independence and Board Size. Results also reveal that Cash Donation, Infrastructure Development and Natural Disaster show significant positive moderating effect on Board Independence with firm’s performance. Similarly, Infrastructure Development and Miscellaneous Project of Philanthropy have also shown positive moderating impact on Board Size and Firm Size with firm’s performance. After using the GMM / DPM technique, three out of five different settings of Corporate Governance, Corporate Social Responsibility and Firm Specific Variables on firm’s performance in the presence of Corporate Philanthropy encountered problem of Reverse Causality, Feedback’s influence, endogeneity and simultaneity. These results showed no variation from previous findings except Corporate Social Responsibility has positive significant impact on firm’s performance. Results confirmed that Corporate Philanthropy moderates the relation between Corporate Governance and firm’s performance. Results reveal that Market based measures (Earning Yield and Tobin’s Q) are more dynamic in nature. Nonexistence of standard format for reporting philanthropy data poses difficulty in making rational analysis and developing uniformity basis for all the firms. The philanthropic contribution of any organization is attributed towards the enhancement of firm’s performance. Results unfold that this study will be a guideline for regulatory bodies to formulate a comprehensive policy framework to Pakistan Stock Exchange so that uniformity of reporting philanthropy should be adhered.