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Home > Prevalence of Metastatic Disease in Newly Diagnosed Breast Cancer Patients As Seen on Contrast Enhanced Computed Tomography of the Chest, Abdomen and Pelvis at the Aga Khan University Hospital, Nairobi.

Prevalence of Metastatic Disease in Newly Diagnosed Breast Cancer Patients As Seen on Contrast Enhanced Computed Tomography of the Chest, Abdomen and Pelvis at the Aga Khan University Hospital, Nairobi.

Thesis Info

Author

Obala, Gregory

Department

Imaging and Diagnostic Radiology (East Africa)

Program

MMed

Institute

Aga Khan University

Institute Type

Private

City

Karachi

Province

Sindh

Country

Pakistan

Thesis Completing Year

2018

Thesis Completion Status

Completed

Subject

Medicine

Language

English

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676728062059

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Introduction: Breast cancer patients have traditionally been screened for occult metastases with abdominal ultrasound, chest radiography and bone scan although the use of modern tests with greateraccuracy such as computed tomography (CT), 2-[fluorine-18] fluoro-2-deoxy-d-glucose positron emission tomography (FDG PET) and Magnetic resonance (MR) imaging is on the increase. The use of contrast enhanced CT (CECT) in the staging of patients with newly diagnosed breast cancer has increased greatly in clinical practice in view of it being widely available and relatively cheapwhen compared to other modalities such as MRI and PET imaging. The clinical utility of routine staging CECT is yet to be fully defined as there is no agreement between protocols on what clinical stage, size of tumour or extent of lymph node involvement that should trigger the use of advanced imaging such as staging CECT or even MRI/PET at time of breast cancer diagnosis. Objective: This study was done to determine the prevalence of distant metastasis as seen on staging CECT done at time of diagnosis in patients with new diagnosis breast cancer. Study design: Cross sectional study with data gathered retrospectively. Methods: Results of CECT examinations done for staging of patients with new diagnosis breast cancer were reviewed retrospectively to determine the prevalence of metastatic disease at time of diagnosis. CECT examinations done between January 2014 andJanuary 2017 at Aga Khan University Hospital in Nairobi (AKUH, N) were used in this study. Additional data were gathered from patient files and pathology records. Results: The overall prevalence of distant metastasis was 14.8 % in the 183 patients recruited in this study. Using tumour size and nodal status staging (AJCC 7thEdition), 38 patients were classified as stage I (21%), 89 patients were classified as stage II (49%) and 56 patients (30%) were classified as stage III. Following the results of CECT,noneof the 38 patients at stage I were upstaged while6 of the 89 patients (7%) and 21 of the 56 (37.5%) at stage II andIII respectively were upstaged to stage IV breast cancer. Conclusions: The overall prevalence of distant metastasis was 14.8 % in the 183 patients recruited in this study. The general practice of using staging CECT to screen for metastasis in patients with newly diagnosed breast cancer was useful in patients with locally advanced breast cancer (stage III) and not useful in those with stage I disease. 7% of patients were upstaged from stage II breast cancer to
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محمد خان وامق

عہد اورنگ زیب کے محمد خان وامق سیالکوٹ کے پہلے اردو شاعر ہیں۔ وہ اپنے وقت کے اہم شاعر تھے۔ وامق وڈہرہ قوم کے کھتری تھے اور ان کو مسلمان کرنے کا فخر اس وقت کے جید عالم مولانا عبد اﷲچلپئی کو تھا جنہوں نے ان کا نام محمد خان رکھا۔ اشفاق نیاز تاریخِ سیالکوٹ میں آپ کے بارے رقمطراز ہیں:

آپ نہ صرف اعلی درجے کے شاعر تھے بلکہ ایک انشا پرداز بھی تھے اور یہی شہرت اور قابلیت انہیں دربارِ عالمگیر تک لے گئی۔ بادشاہ ان کا بہت قائل تھا بعد میں بادشاہ نے ان کے فن و ادب کی قدر کرتے ہوئے انہیں اخلاص خاں کے اعلیٰ خطاب سے سرفراز بھی فرمایا۔ آپ صاحبِ دیوان بھی تھے۔ اردو اور فارسی میں شاعری کرتے تھے مگر افسوس کہ باوجود سعی بسیار کے کلام مفقود ہے۔ (۱)

راقم الحروف بھی کوشش کے باوجود ان کا اردو کلام دریافت نہیں کر سکا۔تاریخِ سیالکوٹ کے مطابق آپ نے محمد شاہ کے عہد ۱۷۶۶ء میں سیالکوٹ میں وفات پائی۔(۲)

 

۱۔اشفاق نیاز‘ ’’تاریخِ سیالکوٹ‘‘ ‘ سیالکوٹ‘ سیالکوٹ ایڈورٹائزرز ‘ ۲۰۰۹ء، ص : ۲۹۳

۲۔           ایضاً‘ ص: ۲۹۴

عبد الرحمن الكيلاني وكتابه مترادفات القرآن مع الفروق اللغوية

This article deals with “Synonymy” in Arabic. Generally “Synonymy” is a radical source which keeps language more advanced and developed. The “Synonymy” has gained attention of early Arabic linguists’ and scholars while compiling the sacred language data, for instance two major linguists Abū al-Mālik ibn Qutaybah al-Asma’i and Ibn Khalawayh focused on synonymity of words, eventually they considered memorisation of synonym words as a mark of pride. On the other hand, some other linguists like Abu al-‘Abbās Aḥmed ibn Yaḥy al-Thalb and Abū ‘Alī al-Fārisī have denied the existence of synonymity in Arabic language altogethers. After all, the “Synonymity” of words is considered as a linguistic phenomenon in all languages generally and in Arabic language particularly. A renowned great scholar ‘Abdul Raḥmān al-Kilānī paid countless attention to this linguistic phenomenon and wrote the book the of one is which“مترادف القرآن مع الفروق اللغوية”: entitled comprehensive reference books in the field. He studied Quranic synonyms with their meanings systematically. The article addresses the concept of synonymity with a brief historiography as well as what ‘Abdul Raḥmān al-Kilānī's book brought us in this field.

Anallysis of F Mathemati Ics Curriculu Umat Secondary School Level in Pakistan

The curriculum being the main instrument of education can not be static. As the frontiers of knowledge expand with time, the curriculum should be updated and restructured to enhance the quality and standard of education. Curriculum analysis and change has been a burning issue in Pakistan during the recent past. The present study was designed to analyze the curriculum of mathematics for class 9 th prescribed by the Punjab Text Book Board Lahore. The major objectives of the study were: 1) to analyze the policy objectives of the Mathematics curriculum at secondary school level in Pakistan, 2) to analyze Mathematics curriculum process with special reference to objectives, content, methodology and evaluation, 3) to critically review the subject matter of the Mathematics in order to point out the strengths and weaknesses at Secondary school level in Pakistan, 4) to explore the opinion of the curriculum experts about the worth of Mathematics Curriculum at secondary school level in Pakistan, and 5) to suggest measures for the improvement of secondary school Mathematics curriculum in Pakistan. Population included all the experts of national curriculum in the subject of Mathematics working in the Ministry of Education Islamabad, Curriculum Bureau in Provinces and working teachers of the Mathematics at secondary school level in Pakistan. One thousand and eighty mathematics teachers from 540 secondary school of Punjab were randomly selected, whereas 30 curriculum experts/educationists were contacted for their opinion. A questionnaire for teachers and an interview schedule for experts were used to collect data. Data was collected personally as well as through contacts and mail. Percentage and Chi Square test were used for statistical treatment of the data. The study xwas delimited to mathematics curriculum of 9 th class and the teachers were selected from the public secondary schools of Punjab province only. The opinion, suggestions made by the respondents were tabulated and analyzed. Discussion, recommendations were given in the light of the findings of the study.