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Prevalence of Suspicious Ultrasound Findings in Patients With Mammographic Focal Asymmetry at Aga Khan University Hospital, Nairobi

Thesis Info

Author

Mavuti, Jacqueline Ndunge

Department

Imaging and Diagnostic Radiology (East Africa)

Program

MMed

Institute

Aga Khan University

Institute Type

Private

City

Karachi

Province

Sindh

Country

Pakistan

Thesis Completing Year

2015

Thesis Completion Status

Completed

Subject

Medicine

Language

English

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676728063035

Similar


Background: Breast cancer has become the leading cancer in women in both economically developed and developing countries, accounting for 25% of all cancers diagnosed worldwide in 2012. The cornerstone of breast cancer control remains early detection in order to improve outcomes and survival. Thus far the only breast cancer screening method that has proved to be effective is mammography. Although mammography is the mainstay of early detection, a fundamental limitation is its low inherent contrast difference between the soft tissue structures in the breast. Mammographic specificity relies on the ability to distinguish benign from malignant breast lesions based on their margins and morphological features. When breast malignancy presents with subtle mammographic features such as focal asymmetry, its specificity is reduced. Overall, the larger portion of false -negative mammograms comprises of cancers which are visible in retrospect as ‘minimal sign’ cancers. Additional imaging with ultrasound is useful to further characterize areas of mammographic focal asymmetry, and sonographic findings are used to determine the need for subsequent biopsy for histological confirmation. However, mammographic focal asymmetry has historically not been subjected to adequate follow up, and there is limited data in radiology literature regarding ultrasound findings in its evaluation. Objective: To determine the prevalence of suspicious ultrasound findings in patients with mammographic focal asymmetry. Methods: This was a cross-sectional study, whereby women presenting for mammograms at the Radiology Department with a mammographic descriptor of focal asymmetry (as per the American College of Radiology guidelines) and recommendation for additional imaging evaluation with breast ultrasound were consecutively recruited. The whole breast ultrasound images were evaluated for normal and abnormal findings, and allotted a final imaging assessment categorisation using the ACR Breast Imaging – Reporting and Data System (BI-RADS®) ultrasound lexicon. Ultrasound BI-RADS® 1-3 categories were assigned as benign findings, while ultrasound BI-RADS® 4 and 5 were assigned as suspicious findings. A total of 141 patients were enrolled. Analysis: Data collected were entered into a spreadsheet application (Excel for Microsoft Windows, Microsoft Corporation) and analysed using Stata® version 11.2. The proportion of suspicious ultrasound findings in mammographic focal asymmetries was calculated. Results: A total of 141 patients met the eligibility criteria during the study period and were enrolled into the study. The median age was 50 years, with a range of 31 to 79 years. The prevalence of suspicious ultrasound findings in patients with mammographic focal asymmetry was 7.1%. There was equal involvement of right and
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استفہام بمعنی اقرار

استفہام بمعنی اقرار

بعض اوقات استفہام اقرار کے معنی میں استعمال ہوا ہے ۔ مقصد غور و تدبر کے بعد مخاطب کو اقرار واعتراف پر آمادہ کرنا ہے۔ قرآنی ادب میں اسلوب کے بڑے عمدہ طریقے سےاستعمال کیا گیا ہے ۔ جیسے :

"أَفَتُؤْمِنُونَ بِبَعْضِ الْكِتَابِ وَتَكْفُرُونَ بِبَعْضٍ فَمَا جَزَاءُ مَنْ يَفْعَلُ ذَلِكَ مِنْكُمْ إِلَّا خِزْيٌ فِي الْحَيَاةِ الدُّنْيَا”[[1]]

"کیاوہ بعض احکام پر ایمان رکھتے ہو اور بعض کے ساتھ کفر کرتے ہو (١) تم میں سے جو بھی ایسا کرے، اس کی سزا اس کے سوا کیا ہو کہ دنیا میں رسوائی) اس آیت میں اللہ تعالیٰ بنی اسرائیل سے ان کا یہ جرم باور کرانا چاہتاہے کہ تمہاری ازل سے یہ کوشش رہی ہے کہ تم کتاب کے اس حصے پر ایمان لاتے ہو جو تمہاری خواہشات کےمطابق ہو اور جو تمہاری ہوائےنفس کی تکمیل میں رکاوٹ بنے اس کا انکار کر دیتے ہو کیا تمہارے یہ رویہ نہیں رہا ہے" ۔

"أَلَمْ يَجْعَلْ كَيْدَهُمْ فِي تَضْلِيلٍ ، وَأَرْسَلَ عَلَيْهِمْ طَيْرًا أَبَابِيلَ"[[2]]

"کیا اس نے ان لوگوں کی ساری چالیں بیکار نہیں کر دی تھیں؟ او ران پرغول کے غول پرندے چھوڑ دیے تھے"۔

یہاں سوال کرنا مقصود نہیں بلکہ مخاطب کو یہ باور کرانا مقصود ہے کہ ایسا ہو چکاہے ۔

" قَالَ أَتَعْبُدُونَ مَا تَنْحِتُونَ (۹۵) وَاللَّهُ خَلَقَكُمْ وَمَا تَعْمَلُونَ"۔[[3]]

"تو آپ نے فرمایا تم انہیں پوجتے ہو جنہیں (خود) تم تراشتے ہو حالانکہ تمہیں اور تمہاری بنائی ہوئی چیزوں کو اللہ ہی نے پیدا کیا ہے "۔

قاضی ثناء اللہ پانی...

Machine Vision based Computer-Aided Detection of Pulmonary Tuberculosis using Chest X-Ray Images

Tuberculosis (TB) is a lethal disease and developing countries are struggling to overcome this health hazard especially in rural areas and faced globally. Therefore, serious measures are required to reduce this global health hazard. Millary and pulmonary are the most common types of tuberculosis occurring globally. X-ray is the preliminary method to detect tuberculosis; however, the diagnosis is quite often subject to human error. In contrast, the chances of curing Tuberculosis depend on its timely and accurate diagnosis. Therefore, an intelligent machine learning algorithm is developed in this study to assist the clinician in an accurate TB identification in x-ray images. The proposed method pre-processes the X-ray image, enhances its quality and extracts the features of each class which are further passed on to a Deep Convolutional Neural Network-based design for the X-ray image classification, followed by the identification of the tuberculosis type i.e. Millary, Cavitary, Healthy. The classification accuracy for the developed method resulted in 88% and 89% for millary and cavitary TB diseases in x ray images.

Determinants of Corporate Social Resposibility for Sustainable Development

Corporate social responsibility (CSR) is a phenomenon that has received considerable attention not only from academicians & from researchers but also from corporate sector since it has multidimensional effects on their performance. It is imperative to note that companies may use CSR as a tool to manage many types of stakeholders, including stakeholders outside of the organization and outcomes that go beyond financial result. This notion will lead the companies towards new era mostly stated as sustainability, where companies act responsibly towards social, environmental and societal issues at large. The current study seeks to model and empirically test the relationship amongst determinants and outcomes (i.e. psychological and performance) of corporate social responsibility, specifically this study probe into relationship between ethical leadership, corporate social responsibility, trust and performance variables (organizational citizenship behavior, task performance behavior & counterproductive work behavior). Furthermore, this study also examines the role of ethical climate between the relationships of ethical leadership and CSR (ethical climate acts as a moderator). The current study has used mix methods approach i.e. quantitative and qualitative research design. The population of the study is scheduled and listed commercial banks in Pakistan. The study has used both simple random probability sampling technique and purposive sampling technique. Data was collected using mix methods from the sampled individuals for quantitative analysis. 500 responses were received back from the employees of banks from major cities (i.e. Karachi, Lahore, Islamabad, Rawalpindi and Peshawar) however, only 420 were useable. Fifteen top executives were interviewed out of the thirty-five listed commercial banks for qualitative analysis in respect to sustainable development. Data was analyzed using Partial Least Square Structural Equation Modeling (PLS-SEM). Furthermore, necessary tests were conducted using Statistical Package for Social Sciences (SPSS) version 23. Findings indicate that ethical leadership has positive impact on CSR and significantly contributes towards defining the underlying processes of CSR. Results confirmed that ethical climate acts as a moderator between the relationship of ethical leadership & CSR. The CSR activities are project based and identified through an internal mechanism sometimes based on need and philanthropic prospective. The integrated conceptual framework of the current study will be helpful in decision making as to determine the impact of CSR on performance variables. Similarly, the current study will help corporate sector in devising strategies and policies of sustainability for competitive advantages. The researcher contends that this is one of the few studies in Pakistani context to understand the underlying processes linking ethical leadership with CSR along with the performance outcomes and ethical climate as moderator. This will certainly provide a comprehensive overview of CSR and sustainability prospective in Pakistan.