Introduction: Human immunodeficiency virus disease (HIV) is a worldwide health problem. It is estimated that 38.6 million people are infected with HIV globally. It has remained endemic in the African continent for close to 20 years and is a long term developmental challenge in Africa which bears 69 % of the HIV/AIDS global burden. The introduction of highly active antiretroviral therapy (HAART) has caused dramatic improvement in prognosis of HIV disease. Consequently, this has resulted in substantial reduction in Acquired Immune Deficiency Syndrome (AIDS) related morbidity and mortality. In contrast, this has been accompanied by an upsurge in liver- related morbidity and mortality. Studies have shown that deaths resulting from liver diseases rank second to AIDS-related mortality. Liver cirrhosis and hepatocellular carcinoma are the leading causes. Others are steatohepatitis secondary to fatty liver disease. Studies on liver diseases in HIV patients have been done predominantly in those who are coinfected with hepatitis B virus/hepatitis C virus (HBV/HCV). These have shown high coinfection rates in the western countries. On the other hand, Sub-Saharan Africa has lower rates of HIV coinfection with HBV and HCV. Therefore, HIV-monoinfected patients are the majority, yet, there is scarcity of data on liver diseases in these patients. This study aimed to estimate the prevalence of hepatic steatosis and the factors associated with hepatic steatosis in HIV monoinfected patients of African descent at Aga Khan University Hospital Nairobi. Objectives: Primary objective - To determine the prevalence of hepatic steatosis in HIV monoinfected patients of African descent on grey scale ultrasonography Secondary objectives – To determine factors associated with hepatic steatosis in HIV monoinfected patients of African descent on grey scale ultrasonography. Methods: This was a prospective cross-sectional study done between April 2015 and November 2015 through consecutive enrolment of 109 eligible HIV monoinfected patients of African descent at Aga Khan University hospital Nairobi (AKUH, N). The study was carried out in AKUH, N HIV clinic and radiology department. Results: Hepatic steatosis was diagnosed in 11% of the 109 patients (95% CI 5.5 - 17.4%). Male patients had a significantly higher prevalence of hepatic steatosis (19.3%) compared to the females (1.9%), AOR 15.4 (95% CI 1.7-138.0), p=0.014. Patients on HAART had a significantly lower prevalence of hepatic steatosis (6.5%) compared to those patients who were HAART naïve (37.5%), AOR 0.1 (95% CI 0.0-0.4), p=0.001. Other patient characteristics such as alcohol consumption, viral load, BMI and hyperlipidemia were not
پاکستان سے محبت نحمدہ ونصلی علی رسولہ الکریم امّا بعد فاعوذ بااللہ من الشیطن الرجیم بسم اللہ الرحمن الرحیم معزز اسا تذہ کرام اور میرے ہم مکتب ساتھیو! آج مجھے جس موضوع پر لب کشائی کی دعوت دی گئی ہے وہ ہے:’’پاکستان سے محبت ‘‘ صدرِذی وقار! محبت ایک ایسا لفظ ہے جس کے معانی کی خوشبو سے گردونواح کی فضاء معطر ہو جاتی ہے، جس کی بارش کے قطرے نفرت، حسد، بغض کی دھول کو ختم کر کے نکھار پیدا کر دیتے ہیں، جس سے معاشرے میں موجود عداوت ، عصبیت ، اقرباء پروری کے کھلیانوں میں موجود غلاظت کے ڈھیروں سے اُٹھنے والی سرانڈ کاو جود ختم ہو جاتا ہے ،محبت کی آبیاری سے نشوونما پانے والے گلستان جنت کا نمونہ پیش کرنا شروع کر دیتے ہیں اور ہر سو سبزہ ہی سبزہ نظر آتا ہے جو ایک نیک شگون تصور کیا جا تا ہے۔ جنابِ صدر! میں پاکستان سے محبت کیوں نہ کروں!یہ تو میرے آباؤ اجداد کی کاوش ہے، میں اس کے گلی کوچوں کو حرز جاں کیوں نہ بناؤں یہ تو میرے اسلاف نے اپنی جانوں کا نذرانہ پیش کر کے حاصل کیا ہے، مجھے اس کی فضاؤں سے، مجھے اس کی ہواؤں سے، مجھے اس کے گلستانوں سے، مجھے اس کے بیابا نوں سے، مجھے اس کے کھیتوں کھلیانوں سے، الغرض مجھے اس کے ذرے ذرے سے پیار ہے۔ معزز سامعین! پاکستان میراوطن ہے، پاکستان میر ا دیں ہے، پاکستان میرا گھر ہے، پاکستان کی مٹی مجھے جان سے بھی زیادہ عزیز ہے، ایسا کیوں نہ ہو، میں مسلمان ہوں میرا ایمان ہے کہ وطن کی محبت ایمان سے ہے۔ وطن سے محبت کر کے، پاکستان سے محبت کر کے جہاں میں بحثیت انسان اپنا فرض ادا کر رہا ہوں وہاں اپنادینی فریضہ بھی پورا کر...
This study aims to look at the determinant factors that affect the intense / intention to do child marriage to adolescents in Banggai Laut. This research method using a cross sectional study. The research sample consisted of 192 teenage students in SMA Negeri 1 Banggai and SMA Negeri 2 Banggai. Chi-square test and multiple logistic regression were used to analyze the data. The results of the bivariate analysis showed that there was an effect of attitude, family drive and behavior control on the intention to do child marriage (p <0.05). The results of the multivariate analysis showed that there was only one variable that had a p value <0.05, namely the family drive variable with p = 0.029. From exp (B) = 4,871> 1 is a risk factor and the Cl value is 95% more than 1 (1,178-20,142) so that OR is significant. This means that respondents who are influenced by family encouragement have a risk of 4,871 times having the intention of engaging in child marriage. It can be concluded that there are many factors that can influence adolescents in engaging in child marriage. All levels of society should protect children together and stop the practice of child marriage in society. The smallest and closest family unit for the child should be able to protect it, not be the main factor that encourages underage marriage.
The study aimed to explore the impact of executive compensation and ownership concentration on firm performance. For this purpose relevant part of 524 annual reports of companies listed on KSE 100 are examine during the period from 2008 to 2014.
The regulatory framework (the Companies Ordinance 1984 and Code of Corporate Governance 2002) is very well articulated and covering all aspect of compensation and ownership concentration but the compliance of the law is not significant in Pakistan. Since many SROs are required to maintained functional website having information regarding company profile, Governance, investor relationship, media, election of directors, statement of compliance and financial statement. I am unable to access functional website of at least 15% of targeted sample (KSE 100 index).
Since majority of the companies in Pakistan are family centered that lead to ownership centering and these family owned companies are performing well therefore the owners does not open the slot for individual/institutional investors to avoid hostile takeover. CEO dominance is high under such conditions since the probability is higher that CEO is the owner of the company and he/she has the major role in BOD selection. This dominating position empowers him/her to restrict the monitoring role of the BOD and directors forced to ratify management decisions. CEO uses the same influence for setting up the compensation of top executives. This study also confirms that compensation has the positive relationship with firm performance where majority shareholding is with institutional investor but the same relationship become negative if ownership changes to non-institutional investors. Companies having financial business are subject to multiple legal / regulatory reviews in Pakistan. Studyreveals that legal regulation has impact on this relationship since I have observe that top executive compensation relationship with the firm performance is insignificant in companies having financial business in the comparison to the companies involve in non-financial business where I found some relationship between top executive compensation and firm performance.
Ownership structure in Pakistan also has the impact on relationship between ownership concentration and firm performance. Study observes the negative relationship between ownership concentration (represent by capital owned by top five shareholders) and firm performance. Market as whole observed an approximate reduction of .033% in AROA by Increase of 1% in ownership concentration. Institutional investors have external exposure and experience to manage companies therefore their ability to produce good results are higher. Study confirmed that ownership concentration have the positive relationship with firm performance where majority of the shareholding is with institutional investor but the same relationship become negative if ownership changes to non-institutional investors.
It noted that results of above mention variables are varying in different sectors. Impact of executive compensation and ownership concentration on firm performance is high in sectors like Services, Cement, Chemical, Fertilizer, Oil and Gas and other industry while sectors like Banks, Food, Power Generation and Distribution have limited impact and no impact have been noted in Non-banking Finance Companies and Textile.