Search or add a thesis

Advanced Search (Beta)
Home > Stratification of White Matter Hyperintensities in Young and Middle Age Adults Using Hydrogen Magnetic Resonance H-Mr Spectroscopy

Stratification of White Matter Hyperintensities in Young and Middle Age Adults Using Hydrogen Magnetic Resonance H-Mr Spectroscopy

Thesis Info

Author

Elvis, M’Mene E.

Department

Imaging and Diagnostic Radiology (East Africa)

Program

MMed

Institute

Aga Khan University

Institute Type

Private

City

Karachi

Province

Sindh

Country

Pakistan

Thesis Completing Year

2011

Thesis Completion Status

Completed

Subject

Medicine

Language

English

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676728067791

Asian Research Index Whatsapp Chanel
Asian Research Index Whatsapp Chanel

Join our Whatsapp Channel to get regular updates.

Similar


Objective: The objective of this study was to stratify white matter hyperintensities on the basis of neuronal integrity in young and middle age adults by comparing the level of N-acetyl aspartate and creatine ratios in white matter hyperintensity lesions and normal appearing white matter using hydrogen magnetic resonance (H-MR) spectroscopy at 1.5 Tesla(T) Methods: Fifty consecutive patients who fulfilled the inclusion criteria aged 18-50yrs who were referred for magnetic resonance imaging(MRI) of the brain at the Radiology department of Aga Khan University Hospital over a six month period between January and June 2011 were included in the study. These patients had undergone routine MRI brain using the department protocol and were found to have white matter hyperintensities ≥5mm and no other intra-axial abnormalities. The patients underwent MR spectroscopy of the white matter hyperintensity lesions and a corresponding region of normal appearing white matter at 1.5 Tesla. Ratios of N-acetyl aspertate/creatine were compared for the white matter hyperintensity lesions and normal appearing white matter. The NAA/creatine ratios of the white matter hyperintensities and normal appearing white matter were analyzed and inferences made regarding neuronal integrity, clinical presentation and location of the white matter lesions. Results:Fifty patients, 25 male and 25 female were included in the final analysis. Thirty nine (78%) patients showed lower levels of NAA/creatine ratios in the white matter hyperintensities compared to normal appearing white matter. Eleven (22%) patients showed higher levels of NAA/creatine ratios in the white matter hyperintensities compared to normal appearing white matter. Paired T test showed a statistically significant difference between the NAA/creatine ratios in the white matter hyperintensity lesions compared to normal white matter(p value of Forty seven (94%) sampled lesions were in the subcortical and deep white matter compared to 3(6%) lesions in the periventricular location. There was no statistically significance difference in the ratios of NAA/creatine between the periventricular and deep white matter lesions. Forty seven (94%) of the study patients presented with headache . Twelve (24%) presented with dizziness. No correlation was found between the levels of NAA/creatine ratios and clinical presentation. Conclusion: This study demonstrates that white matter hyperintensities in young and middle age adults are associated with actual neuronal destruction. These patients should be investigated to define the aetiology and if possible interventions to reverse or prevent further neuronal damage.
Loading...
Loading...

Similar Books

Loading...

Similar Chapters

Loading...

Similar News

Loading...

Similar Articles

Loading...

Similar Article Headings

Loading...

حافظ ہدایت حسین

حافظ ہدایت حسین ؍ علامہ راشد الخیری ؍ مولانا شیر علی
میری علالت کے زمانہ میں ملک و ملت کی کئی نامور ہستیوں نے اس دنیائے فانی کو الوداع کہا حافظ ہدایت حسین صاحب مرحوم اس صوبہ کے مسلمانوں کی بڑی دولت تھے، اس دولت کا چھن جانا ہماری سب سے بڑی محرومی ہے، دلی کے پایہ تخت کی بھی ایک یادگار مٹ گئی، یہ مولانا راشد الخیری کی ذات تھی، جس نے اپنی ساری عمر مسلمان عورتوں کی علمی و ادبی و تعلیمی خدمت گزاری میں بسر کردی، دکن کے خزانہ کا بھی ایک قیمتی ہیرا گم ہوگیا، یعنی مولانا شیر علی صاحب سابق مدرس اعلیٰ دارالعلوم ندوہ و سابق استاد کلام جامعہ عثمانیہ نے وفات پائی، مرنے والے مرگئے، مگر ان کے کارنامے دنیا میں یادگار رہ گئے۔
از صدائے سخن عشق ندیدم خوشت

یادگارے کہ دریں گنبد دوار بماند
)(سید سلیمان ندوی، اپریل ۱۹۳۶ء)

زرتشت ازم کے شعائر، رسوم اور روایات: اسلامی تناظر میں اجمالی جائزہ

Zoroastrianism is an ancient Iranian religion founded by an Iranian Prophet and scholar Zoroaster. It is claimed by some foremost scholars that this is the most ancient religion of the world which influenced the other major religions of the world like, Judaism, Christianity and Islam. The main source to know the Zoroastrianism is Avesta, Denkart and Bundahishn (sacred books) from which we know the terminologies and traditions of this religion. Main two spirits are Ahura mazda (god of pleasure and goodness) and Ahriman (god of evil) and seven more main spirits which are called as angels are Amesha spentas which show the actual spirit and direction of this ancient religion. Some of the concepts and traditions are same which exists in Islam but with different names and features, like prayers and matters after death, heaven and hell. In this article, main focus is on tradition and terminologies of this ancient religion to know its actual spirit to get the basic information and main themes for initial reader of this religion from Islamic theological pers-pective. No doubt, Zoroastrianism is one the amended religions exist on earth yet because of the similarity of various rituals with Islam. However, Zoroastrianism is being considered reve-aled religion and Zoroaster as true prophet of Allah.

The Role of Multinational Companies in Southeast Asia: Case Study of Malaysia

The research of study to know the economic and international business are suitable in order to explain the particular role and existing of Multinational Companies in the South East Asia and specially in Malaysia, the base of this study to describe the process of realism in between of Multinational Companies and South East Asia relationship as well as towards Malaysia, the core role of Multinational Companies in Malaysia since two decades of the 20 th century i.e. from the period of ruling of Dr. Mahathir, in this respect two sets of Questionnaires customers were supplied in all the big cities of Malaysia, this questionnaires from the Managers of Multinational Companies and from Multinational Customers show the total response rate estimated at 62% which is suitable for the study. The above results also supported with secondary data as confirmed all research hypotheses, so pointed out that in manufacturing and services industries dominant the multinational business in Malaysia due to joint venture, in Malaysian foreign joint ventures found of MNCs in the cross borders as well as marketing, trading, manufacturing, consulting, contracting Banking, hotel and insurance field, so multinational group operating across the national border i.e. no need with international production. It is further mention here that the respondents perceived the competitors of the Multinational Companies are in process in Malaysia in economic,20 marketing, and technology field, and the contribution of the Multinational Companies in socio economic developments found as positive in Malaysia. The Researcher of this study also given attention to some aims and objectives for the success of the business of the Multinational Companies in business as related with local cultural awareness found positive in Malaysia, as well as covered some important issue of the Islamic culture in this study, as the help full for the Multinational Companies to obtained more awareness about cultural needs, values and also to sensitiveness of the people generally and Muslims community of Malaysia.