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Home > The Efficacy of Intravenous Hyoscine-N-Butylbromide Buscopan® for the Acceleration of Labour in First Time Parturients: A Randomised, Double-Blind, Placebo-Controlled Trial

The Efficacy of Intravenous Hyoscine-N-Butylbromide Buscopan® for the Acceleration of Labour in First Time Parturients: A Randomised, Double-Blind, Placebo-Controlled Trial

Thesis Info

Author

Mwaniki, Mukaindo A.

Department

Obstetrics and Gynaecology (East Africa)

Program

MMed

Institute

Aga Khan University

Institute Type

Private

City

Karachi

Province

Sindh

Country

Pakistan

Thesis Completing Year

2010

Thesis Completion Status

Completed

Subject

Medicine

Language

English

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676728070655

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Objective: to establish the safety and efficacy of hyoscine-N-butylbromide (Buscopan®) in accelerating labour in first time parturients. Design: a randomised, double-blinded, placebo-controlled clinical trial. Setting: the antenatal clinic and maternity unit of the Aga Khan University Hospital Nairobi, Kenya. Population: first time parturients in spontaneous labour at term. Methods: women were randomised to receive 40mg of hyoscine-N-butylbromide or sterile water for injection intravenously once they were confirmed to be in active labour. The dose could be repeated once after four hours. Outcome measures: the main outcome measure was the duration of labour from diagnosis of active stage to delivery. Secondary outcome measures were rate of cervical dilatation and postpartum satisfaction score. Safety aspects such as drug adverse effects, APGAR scores and postpartum hemorrhage were explored. Results: a total of 85 were randomised and 79 yielded data for analysis. Of these 37 received hyoscine-N-butylbromide and 42 received placebo. There was no significant difference in the mean duration of active labour to second stage between the drug and placebo arms (396.2 versus 389.3 minutes, respectively, p=0.881, 95% CI -85.9 to 99.8). The mean rate of cervical dilatation in the drug arm was 1.17 centimetres per hour (cm/hr) compared to 1.22cm/hr in the placebo arm. This difference was not statistically significant (p value=0.832, 95% CI -0.5 to 0.4). The postpartum satisfaction scores were similar between the two arms. Hyoscine-N-butylbromide was well tolerated without any major adverse effects observed in either arm. Conclusion: hyoscine-N-butylbromide does not shorten the duration of labour in first time parturients in spontaneous labour. It also does not change maternal satisfaction with care received and is not associated with major adverse outcomes in the mother or newborn.
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معاشرتی جرائم کے اسباب اور ان کا ممکنہ تدارک اسلامی تعلیمات کی روشنی میں

Today in the world, the human beings are crunch in crimes in developed society or in undeveloped society. As a result the whole world has become insecure and unsafe. A society and nation can perish and drowned due to its cruelty and crimes. The Muslim society is also being victims of such crimes. According to the scholars the basic reason of this issue is illiteracy and get for away from Islamic teachings while fearless from God and from the Day of Judgment, social injustice, instability, destabilization, disunity and dis-integrity, away from knowledge, negative role of media and impatience tolerance are also considered as major factors. The scholars and reformers are suggested to control the crimes through laydown of justice or establishment of Courts and spread of knowledge, bring awareness among the peoples, establishment of educational institutes in a society. In this article it has been point out the major causes of social crimes and their potential remedy in the light of Qur’an and Sunnah.

Synthesis, Characterization and Analytical Applications of Polypyrrole-Metal Oxide Composites

This thesis has been divided into four chapters. The first chapter is about the introduction of polypyrrole (PPy) and other conducting polymers (CPs). The importance and drawbacks of conducting polymers have been thoroughly discussed followed by the discussion about the need of composites of these polymers. The importance of CPs-metal oxide composites over individual components has been deliberated. The relevant literature and references have also been included. The second chapter is related to the synthesis, characterization and analytical applications of PPy-vanadium penta oxide (V2O5) composites. The materials were synthesized in aqueous medium by chemical oxidation polymerization method using FeCl3.6H2O as an oxidant followed by characterization using Fourier transform infrared (FT-IR) spectroscopy, X-ray diffractometer (XRD), thermogravimetry analyzer (TGA), scanning electron microscopy (SEM), energy dispersive X-ray (EDX) technique, surface area and pore size analyzer, UV-visible spectrophotometry and LCR-meter. PPy was amorphous while the composites were crystalline in nature. The content of V2O5 improved the compactness, thermal stability, surface area and electrical conductivity of the composites. The band gap energy was found to be of the same value for all the composites. The gas sensing properties of the materials were checked for ammonia gas and some other organic liquid vapors. The composite PPy/8%V2O5 was of highest sensitivity and selectivity towards ammonia at room temperature. The limit of detection (LOD, response time and recovery time of this material was 1.4 ppm, 10.5 and 81.6 s, respectively. The performance of this composite has been compared with the reported data. In the third chapter, synthesis, characterization and analytical applications of PPy-MnO2 composites have been elaborated. The composites were synthesized and characterized by the same procedure as mentioned for Chapter-2. The content of MnO2 has almost same x effect on the properties of these composites as in case of PPy/V2O5 composites. However, the band gap energy was found to decrease continuously with increase in the percent amount of MnO2 in the composites. After studying the gas sensing characteristics, the composites PPy/10%MnO2 was found of unique properties with respect to its sensitivity, selectivity and limit of detection towards ammonia gas. The response of this material was far better than the already done work. The LOD was 0.4 ppm with response and recovery time 32.1 and 40 s, respectively. In the fourth chapter, unique PPy/V2O5-MnO2 hybrid composites has been synthesized, characterized and applied as gas sensor by the same methods as discussed for PPy/V2O5 composites. These materials were also applied as gas sensor. The composite PPy/4%V2O5-5%MnO2 (S3) was of better performance as compared to the reported hybrid composites regarding ammonia gas sensitivity. The LOD, response and recovery time of the material at room temperature was 5 ppm, 75 and 76 s, respectively.