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Home > Two to Nine Year Review of Breast Conservation Therapy Bct for Breast Carcinoma: Clinico-Pathological Features and Survival in a Single Centre in East Africa

Two to Nine Year Review of Breast Conservation Therapy Bct for Breast Carcinoma: Clinico-Pathological Features and Survival in a Single Centre in East Africa

Thesis Info

Author

Orerah, George

Department

General Surgery (East Africa)

Program

MMed

Institute

Aga Khan University

Institute Type

Private

City

Karachi

Province

Sindh

Country

Pakistan

Thesis Completing Year

2018

Thesis Completion Status

Completed

Subject

Medicine

Language

English

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676728073654

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Introduction: Breast conservation therapy compares to mastectomy in terms of overall survival and disease free survival. However it’s utilization in most parts of the sub-Sahara Africa is minimal with various factors cited: patient preference, provider preference and adverse effects of or limited access to radiation therapy. The aim of this study was to determine the clinico-pathological profile and outcomes of breast cancer patients treated with breast conservation therapy or mastectomy at a single referral centre. Methods: The Aga khan university hospital is one of the institutions in East Africa, where breast conservation therapy is practiced. We retrospectively analysed the details of breast cancer patients who underwent breast conservation therapy from the year 2008 to 2015 and compared this with patients who had undergone mastectomy during the same period. Results: Ninety one patients who had breast conservation therapy and 187 patients who underwent mastectomy were included in this study. The following factors were correlated with the type of surgery: age <35, 35-50, >51 years, parity, grade, stage, histological subtype, receptor status, neo-adjuvant therapy, adjuvant therapy and re-excision rate. The majority of patients, 38.1% (n=106) had stage II breast cancer. Although there was no stage to stage comparison between the breast conservation group and the mastectomy group, patients who had breast conservation were likely to be younger, with tumour grade I or III and luminal A molecular subtype. There was no significant correlation with being nulliparous, grade II tumours, having received neoadjuvant chemotherapy or re-excision rates. Patients who had mastectomy were likely to be older with grade II breast cancer and had adjuvant chemotherapy. Conclusion: The present study concluded that with proper pre-operative patient selection, breast conservation therapy has comparable clinico-pathological characteristics and outcomes to mastectomy.
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مجید احمد تاثیرؔ

مجید احمد تاثیرؔ (۱۹۱۲ء۔۱۹۸۶ء) کا اصل نام مجید احمد اورتاثیرؔ تخلص کرتے تھے۔ آپ سیالکوٹ میں پیدا ہوئے ۔ میٹرک مادرِ علمی علامہ اقبال سے پاس کیا۔ ۱۹۳۳ء میں امر تسر کے ایم اے اوکالج کے طالب علم بھی رہے۔ جہاں ان دنوں ڈاکٹر رشید جہاں اور میاں ڈاکٹر محمود الظفر اُستاد تھے۔ مجید تاثیرؔ امر تسر کی ادبی محفلوں میں شعر و شاعری کرتے رہے۔ فیضؔسے ان کے پرانے تعلقات تھے۔طب کی تعلیم کے لیے تاثیر طبیہ کالج دہلی چلے گئے۔ اس زمانے میں نظم کی طرف توجہ ہوئی اور جوش ملیح آبادی سے دوستی ہوئی۔سیالکوٹ میں تاثیر نے بڑے بڑے مشاعرے کروائے۔ جن میں جوشؔ اور جگرؔ جیسے شاعروں کو مدعو کیا گیا۔(۵۸۴)

لاہور آکر تاثیر نے کچھ عرصہ ملازمت بھی کی۔ آپ نے انار کلی میں ہمدرد مطب قائم کیا۔ جو ش ملیح آبادی جب بھی لاہور آتے تھے ان کے ہمراہ جو چند اصحاب موجود رہتے تھے۔ ان میں تاثیر بھی تھے جوش صاحب مجید تاثیر کی رباعیات کی بہت زیادہ تعریف کرتے تھے۔(۵۸۵)

اُن کا شعری مجموعہ ’’رباعیات تاثیر‘‘ الوقار پبلی کیشنز لاہور نے ۲۰۰۰ء میں شائعکیا۔ یہ مجموعہ کلام رباعیات ،رومانی نظموں اور غزلیات پر مشتمل ہے۔ اس مجموعے کے دو سو سات صفحات ہیں۔اس کتاب کے آغا ز میں ڈاکٹر وحید قریشی نے ’’پیشِ لفظ‘‘ احمد ندیم قاسمی نے تعارف’’مجید احمد تاثیر‘‘ ناہید سلمیٰ نے مضمون’’ تجھے اے زندگی لاؤں کہاں سے‘‘ ڈاکٹر سید عبداﷲ نے تعارف کتاب’’رباعیاتِ تاثیر ‘‘ ڈاکٹر عبادت بریلوی نے تعارف’’رباعیاتِ تاثیر‘‘ اور جوش ملیح آبادی نے ’’تعارف مجید تاثیر ‘‘پیش کیا ہے۔ جوش نے تاثیرؔ کے تعارف کے ساتھ ایک رباعی بھی لکھی ہے۔ جو درج ذیل ہے:

چرخ شعر و ادب کے تارے تم ہو

 

;جوئے قند و شکر کے...

Freedom of the Press: The War on Words (1977-1978)

Journalism in Pakistan has passed through successive phases of trials and tribulations. The crises journalism had to undergo since independence had their origin both in the state policies as well as the authoritarianism embedded in the society. The book under review does not claim to divulge into the societal challenges which have emerged more visibly in the last three or four decades, especially, in the context of the spread of religious extremism and ethnic and other types of militancy in the society. Studies need to be done on these aspects as well as the external factors that have had impact on the growth and the content of media. The latter has come in the garb of globalization that has greatly affected the local environment and has come to strongly affect, if not directly dictate, what the media should encompass and present. Leaving the societal and global aspects aside, the role of the state and the successive governments has a lot to offer to be written about by way of what the media has endured in the last seventy plus years. It doesn’t need too much of pondering to conclude that the major pressures over media have come from the governments who, by and large, had been quite at unease with independent flow of information, and criticism of their policies. And, unfortunately, this process had begun right after Independence when newspapers’ and periodicals’ independent voice was tried to be silenced, and they were pressurized to toe the official line with respect to domestic and foreign policies. Pakistan’s independent journey, unfortunately, began with the imposition of black laws which prohibited dissent and curtailed freedom of expression in the strongest possible manner.

Prevalence of Vitamin D Deficiency in Exclusively Breastfed Infants at the Aga Khan University Hospital, Nairobi

Introduction: Vitamin D deficiency in infants is a recognized cause of rickets. In the last few years, evidence has emerged of its association with lower respiratory tract infections, food allergy, type 1 diabetes, schizophrenia and various other extra skeletal health effects. Exclusively breastfed infants are especially vulnerable to vitamin D deficiency due to their dependence on previous trans-placental transfer of vitamin D from the mother, dietary vitamin D from breast milk and cutaneous synthesis of vitamin D on exposure to sunlight. The worldwide epidemic of Vitamin D deficiency in pregnancy and the low content of vitamin D in breast milk underlie the high risk of deficiency in exclusively breastfed infants. Data regarding the magnitude of vitamin D deficiency among exclusively breastfed infants in Kenya is needed to inform policies on supplementation of at risk groups. Objectives: The aim of this study was to determine the prevalence of vitamin D deficiency in exclusively breastfed infants using 25(OH)D and to evaluate the relationship between PTH and 25(OH)D in a population of exclusively breast fed infants. Study Design: This was a cross sectional survey carried out in three to six month old exclusively breastfed infants at the Aga Khan University Hospital, Nairobi. Methods: Ninety-eight infants were enrolled in the study and all had data on their demographics and anthropometric measures recorded. Self-reported data on maternal vitamin D supplementation and sunlight exposure was also collected. A brief physical examination to assess for skeletal signs of rickets was then performed. A blood sample was collected for measurement of serum 25(OH)D, calcium, phosphate and PTH . Prevalence of vitamin D deficiency was analyzed using proportions with 25(OH)D levels below 20ng/ml. PTH, calcium and phosphate levels in the vitamin D deficient and non-deficient groups were compared using analysis of variance(ANOVA). The level of 25(OH)D beyond which there was no PTH elevation was identified by drawing a scatter plot of PTH against vitamin D levels. Tests of association using odds ratio were used to determine the correlation between infant serum vitamin D levels and maternal vitamin D supplementation and sunlight exposure. Skeletal manifestations of vitamin D deficiency in this population were described using bar charts. Results: Prevalence of vitamin D deficiency among exclusively breastfed infants at Aga Khan University Hospital was 23.5% (95% CI 14.9%-32.0%). A further 31.6% were found to have insufficient levels of vitamin D leaving only 44.9% of the population classified as having sufficient levels.