مولوی اقبال احمد خان سہیل
ابھی یہ سطریں زیر تحریر تھیں کہ اعظم گڈھ کی نامور اور صاحبِ کمال شخصیت مولوی، اقبال احمد خان صاحب سہیل نے وفات پائی، وہ علامہ شبلی مرحومؒ کے خاص تلامذہ میں تھے، اپنے زمانہ میں نامور علیگ، عربی، فارسی اور اردو تینوں زبانوں کے ماہر تھے، قوتِ حافظہ اور ذہانت و ذکاوت میں بے مثال، اردو کے نکتہ سنج ادیب اور اردو و فارسی کے قادر الکلام شاعر تھے، قصید گوئی اور نعت و منقبت نگاری میں اس زمانہ میں ان کا جواب نہ تھا، ان کا فارسی کلام ایران کے قدیم اساتذہ کے کلام کی ہمسری کرتا تھا، علمی قابلیت کے لحاظ سے غیر معمولی صلاحیتوں کے مالک تھے، مگر وکالت کے پیشہ نے ان کے جوہروں کو چمکنے نہ دیا، اگر وہ کسی علمی شعبہ میں ہوتے تو ہندوستان کے مشاہیر اہل علم میں ان کا شمار ہوتا، دارالمصنفین سے ان کے تعلقات بڑے گوناگوں اور گہرے تھے۔ اﷲ تعالیٰ اس مداح رسول اور منقبت نگار صحابہ کو آخرت کے انعام سے سرفراز فرمائے۔ (شاہ معین الدین ندوی، نومبر ۱۹۵۵ء)
The learning of Arabic language like any other foreign language contains four main aspects; reading, writing, speaking and understanding while listening.[i] This learning process can be enhanced if the most appropriate Learning Strategy is used. In this paper the most appropriate Learning Strategy of Arabic Language is suggested. The course outlines for Arabic language are thoroughly studied and several professors and experts of Arabic Language from Pakistan, Egypt, Saudi Arabia and Sudan are interviewed. The author, who himself has vast experience in teaching Arabic language, also had the opportunity to sit in the Arabic language classes to observe various strategies and methodologies adopted by different professors while teaching Arabic. In this paper the time spent on teaching Arabic to the students is also discussed. The appropriate size of the class room i.e, the number of students in Arabic language class also matters in improving the quality of Arabic among the students. The matter of teaching Arabic in Arabic only or in the native language of the students will also be touched in here. As the time has changed and the world is moving ahead on a fast pace, it seems necessary to apply the “Direct Method” while teaching Arabic or any foreign language.[ii] This paper will shed light on what is meant by “Direct Method”. The idea of making the student sit and memorize the dry rules of grammar has become obsolete. The idea of telling the student what part of the phrase is subject or predicate, or what is object and what is a noun or verb, may come later. The idea of memorizing the bulk of new vocabulary in the beginning can also be postponed. Hence a paradigm shift is needed here while talking about the Methodology of Teaching Arabic Language, under the heading of “Direct Method”. [i] Muhammad Abdul Khaliq, Professor of Arabic and co-author of 'al-Arabia baina Yadaik'. The author of this research paper had a personal interview with him on 21.03.2014, in the Institute of Arabic Language, King Saud University, Riyadh, Saudi Arabia. [ii] This method is adopted roughly by some great scholars of Arabic language like Dr. V. Abdur Rahim who taught Arabic language for decades in the Islamic University of Madina, Kingdom of Saudi Arabia. The author was fortunate to meet with him many times and get benefitted from his experience. See for details: Abdurrahim, V. (1999), Arabic Course for English-Speaking Students, Leicester: UK Islamic Academy. See also: Abdullah, F. Ibrahim. (1999), Iqra Arabic Reader. Chicago: Iqra International Educational Foundation. Moreover see: Fawzan, Abdurrahman and others. (2004), Al-Arabia Baina Yadaik, Riyadh: Ministry of Education.
Hepatitis C Virus is one of the lethal infections prevailing throughout the world. There are approximately 8.5 million individuals that are infected with this deadly virus in Pakistan. Hepatitis C virus is responsible for acute and chronic viral infection. Chronic hepatitis C virus infection causes persistent inflammation that leads to liver fibrosis, insulin resistance/type 2 diabetes mellitus, liver cirrhosis and finally hepatocellular carcinoma (HCC). There is strong evidence that insulin resistance has a major role in metabolic syndrome, and is a risk factor for increased liver fibrosis in patients with chronic hepatitis C virus infection. However the underlying mechanism of insulin resistance in chronic hepatitis C virus infection is not well known. The present study describes the molecular mechanism of HCV nonstructural protein 5A (NS5A) induced insulin resistance. In this study, we elucidated the molecular mechanism involved in HCV nonstructural protein 5A (NS5A) induced insulin resistance. In the present study human hepatoma cell line Huh 7.5 was transfected with HCV NS5A (Huh 7.5/NS5A) as well as HCV (JFH-1) genomic RNA was transfected into Huh 7.5 cell line (Huh 7.5/HCV) to discern the effect of HCV and HCV NS5A protein upon modulation of insulin signaling pathway. Here, we demonstrated that an increased serine phosphorylation of insulin receptor substrate-1 (pSer307) and Akt (pSer473) in Huh 7.5/HCV infected cells compared to mock infected cells. Interestingly, the Huh 7.5/NS5A cell line showed an increased serine phosphorylation of pSer307 IRS-1 and pSer473 Akt, compared to the mock transfected cells, which is a critical step defining the downstream insulin signaling pathway. Glycogen synthase kinase-3 (GSK-3), the downstream target of Akt, is known to favor gluconeogenesis. Our results revealed a diminished phosphorylation level of GSK-3 in Huh 7.5/NS5A expressing hepatoma cells compared to the mock transfected cells, thereby favoring gluconeogenesis. Forkhead transcription factor (FOX-01) which is another important downstream target of insulin signaling pathway, was shown to undergo reduced phosphorylation level (pSer 256) in Huh 7.5/NS5A expressing hepatoma cells compared to the mock transfected cells. Collectively, these findings suggest a molecular mechanism by which ectopic expression of Huh 7.5/NS5A modulates the insulin signaling pathway at post translational level. There are several gluconeogenic and lipogenic markers lying downstream to the insulin mediated signaling molecules (pSer307IRS-1, pSer473Akt, pSer256Fox-01 and GSK-3). In this study, we observed that Huh 7.5/HCV infected hepatoma cells as well as ectopic expression of Huh 7.5/NS5A leads to enhanced gluconeogenesis through up regulating the mRNA levels of gluconeogenic genes i.e. Phosphoenol pyruvate carboxy kinase (PEPCK) and Glucose-6-phosphatase (G6P) compared to their controls. In the similar way, an elevated mRNA level of Diacyl glycerol acyltransferase (DGAT), a key lipogenic marker, was also observed in Huh 7.5/HCV infected as well as Huh 7.5/NS5A expressing hepatoma cells compared to their controls. Based on these results, we deduce a mechanism through which HCV NS5A is potentially capable of modulating the entire insulin signaling pathway at mRNA and post-translational level thereby paving a way towards insulin resistance, a metabolic syndrome.