المبحث الثاني: مأساۃ الحياۃ وأغنية للإنسان
"مطولة شعرية"
تکتب الشاعرۃ العراقیۃ المشھورۃ " نازك الملائکۃ" في دیوانھا المعروف "دیوان نازک الملائکۃ" أنھا تشرح الظروف الزمنیۃ والنفسیۃ والفکریۃ التي مرت بھا خلال کتابۃ مطولتھا الشعریۃ ’’مأساۃ الحیاۃ وأغنیۃ للإنسان‘‘ عبر عشرین عاماً من سنۃ 1945م إلی 1965م، وتقول : ’’یضم الأثر الشعري الذی أضعہ بین یدي القاریء في ھذا الکتاب ثلاث صور شعریۃ لقصیدۃ واحدۃ أولھا قد نظم بین سنۃ 1945م و 1946م وثانیھا قد نظم سنۃ 1950م وثالثھا متأخر التاریخ حتی 1965م، ویمکن أن تعد کل قصیدۃ من ھذہ القصائد الطویلۃ مستقلۃ عن الأخریین، لو لا أنني قد نسخت بعض الأبیات أحیاناً فنقلتھا من قصیدۃ إلی أخری علی اعتبار أنھا ما زالت ترضي ذوقي رغم مرور السنین‘‘۔
وتقول إنھا نظمت القصیدۃ الأولی عام 1945م وکان عمرھا إذ ذاک اثنین وعشرین عاماً۔ وعندما بدأت في نظم ھذہ المطولۃ فإن دیوانھا الأول (عاشقۃ اللیل) لم یظھر إلی الوجود بعد۔ وأنھا کانت تکثر من قراء ۃ الشعر الإنکلیزي فأعجبت بالمطولات الشعریۃ التي نظمھا الشعراء وأرادت أن یکون في الوطن العربي مطولات مثلھم، فبدأت في نظم القصیدۃ وسمتھا "مأساۃ الحیاۃ" وھذہ القصیدۃ دلیل علی تشاؤمھا المطلق، وأنھا کانت تشعر بأن الحیاۃ کلھا ألم وإبھام وتعقید۔ وتقول: ’’وقد اتخذت للقصیدۃ شعاراً یکشف عن فلسفتي فیھا ھو ھذہ الکلمات للفیلسوف الألماني المتشائم ’’شوبنھاور‘‘: "لست أدري لما ذا نرفع الستار عن حیاۃ جدیدۃ کلما أسدل علی ھزیمۃ وموت۔ لست أدري لماذا نخدع أنفسنا بھذہ الزوبعۃ التي تثور حول لا شيء؟ حتّام نصبر علی ھذا الألم الذي لا ینتھي؟ متی نتدرع بالشجاعۃ الکافیۃ فنعترف بأن حب الحیاۃ أکذوبۃ وأن أعظم نعیم للناس جمیعاً ھو الموت؟"۔
یتضح من ذلک أن الشاعرۃ کانت متشائمۃ مثل الشاعر الانکلیزي شوبنھاور وربما تشاؤمھا یفوق تشاؤم شوبنھا ور لأنھا ھي بنفسھا تعترف بھذا الشيء فتقول:’’والواقع أن تشاؤمي قد فاق تشاؤم شوبنھاور نفسہ، لأنہ۔ کما یبدو۔کان یعتقد أن الموت نعیم لأنہ...
Islam recognizes the status and respect of other faiths and communities for socioeconomic and sociopolitical development. Therefore, the kind Messenger of Allah صلى الله عليه وسلمwas the first ever personality in the human history who accepted the identity of other faiths and involved them in state affairs of the city state of Madīnah in 610 CE/1AH. The citizens of the first Islamic State including Jews, Christians and Polytheists were treated as equal and respected citizens. The door of discussion and mutual cooperation were opened for all faiths and communities of the society. For that purpose, the Holy Prophet صلى الله عليه وسلم set out some special parameters and principles of dialogue and interaction with other faiths. These principles may be freedom of religion, mutual respect and cooperation, interfaith tolerance, focus on common issues, active participation in state and social activities etc. The history is eye witness of this conduct that Muslim rulers and public care these principles and promote them in all ages of the Muslim governance. However due to some reason modern era have been observed of not being compatible with minorities in east as well as in the west. Categorically, they are having encounters with many difficulties, challenges and issues for security, rights and peaceful coexistence in all over the world. Unfortunately, Pakistan have also considered to be the part of hyper national and international sociological environment regarding minorities. In order to overcome these issues and challenges then we must follow the Prophet’s Seerahصلى الله عليه وسلم regarding interfaith dialogue and mutual cooperation in a pluralistic society like Pakistan. In this study, the efforts are made to explore contemporary challenges and its solution in light of the Seerah of the Prophet صلى الله عليه وسلمfrom current sociopolitical context.
Salmonella enterica is a Gram-negative facultative anaerobic bacteria. It belongs to the family of Enterobacteriaceae. Infections caused by Salmonella species are major threat to the human and animal health. After 1-3 days of ingestion of contaminated food, the patient develops diarrhea, fever, vomiting, and abdominal cramps. The situation is exacerbated if not treated promptly. Whole genome sequencing projects of clinically significant serovars of S. enterica have opened new perspectives of medical research. Using the genomic data, novel approaches are being employed throughout the world to find new protein targets for drug designing and screening. Targeting the essential metabolic pathways of the bacteria is the approach which we have focused in our study. The protein sequence and metabolic pathway data of the core proteome of S. enterica was analyzed in comparison to that of Homo sapiens. Various computational tools (BLASTp, CD-HIT, and Shell scripting) and datasets (NCBI, DEG, and KEGG) were extensively utilized to find non-homologous and essential enzymes of the pathogen. We discovered 73 enzymes belonging to metabolic pathways found only in the bacteria but not in H. sapiens, and proposed them as potential drug targets. Later, we selected an essential outer membrane protein complex (LptD/E) of S. enterica involved in lipopolysaccharide assembly, as a target in search of an inhibitor of the PPI complex. Druggable sites at the interface of PPI were identified by PocketQuery followed by virtual screening of the ZINC database of commercially available compounds using the ZINCPharmer tool. Energy minimization and scoring of short-listed compounds was performed using SMINA. A rational screening of >10,000 compounds resulted in 3 compounds depicting favorable polar interactions and optimal conformation for binding with the LptD protein. We propose that this interaction may lead to block the LptD interaction with LptE and lipid molecules and in result may block the LPS assembly.