عبداللطیف اعظمی کی وفات
(سبط محمد نقوی)
آج ۱۸؍ مئی کو لکھنؤ کے ایک اردو روزنامے میں رضا لائبریری رامپور میں منعقدہ ایک تعزیتی جلسے کی کاروائی نظر سے گزری، اس میں تین ادیبوں کی وفات پر اظہار غم دالم کیا گیا ہے۔ ان میں سے ایک نام محب محترم عبداللطیف اعظمی صاحب مرحوم کا بھی ہے۔ ان کے ایسے مستند دانشور کے فقدان کا جو صدمہ ہوا وہ اپنی جگہ پر ہے۔ اس کا ملال مستزاد ہے کہ وہ بہت چپ چپاتے رخصت کردیئے گئے۔ ریڈیو پر بھی یہ خبر اذیت اثر سننے کو ملی۔ لکھنؤ کے ان تین اردو اخباروں میں نظر سے گزری جو ہمارے یہاں آتے ہیں۔
مرحوم جامعہ ملیہ اسلامیہ کے انتظامی عملے میں تھے لیکن تعلیمی دور سے لے کر سبکدوشی کے بعد تک مرحوم کا قلم گل افشاں رہا۔ مولانا شبلی نعمانی مرحوم کے دفاع میں ان کا جہاد اور ماہنامہ جامعہ کے احیاء میں ان کی سعی مشکور۔ ان کے عدیم النظیر تاریخی کارنامے ہیں۔
مرحوم سے ملاقات کے موقع تو بس تین چار بار آئے مگر خط و کتابت کافی رہی۔ آخر میں میرے کسی فقرے سے بددل ہوکر مراسلت کا سلسلہ قطع کردیا تھا، پھر بھی کسی بات کے سلسلے میں ہیچ مداں کے معلومات جاننا چاہے تھے تو یاد فرمایا تھا۔
مجھے نہایت خوش اخلاق، مہمان نواز اور کریم النفس انسان لگے۔ ان سے آخری ملاقات جب ہوئی تو برادرم ضیاء الحسن فاروقی صاحب بھی وہیں تشریف فرما تھے۔ یہ ملاقات ان دونوں حضرات سے آخری تھی۔ افسوس ہے کہ وہ نسل بھی اب اٹھتی جاری ہے، جس نے بزرگان پیشیں کے دور کا ادراک کیا تھا۔ میں ان دونوں کے لئے دعائے مغفرت کرتا ہوں۔ فقط والسلام: سبط محمد نقوی۔ ( جون ۲۰۰۲ء)
عبداللطیف اعظمی
افسوس ہے کہ ۱۰؍ مئی ۲۰۰۲ء کو...
This research aims to find out whether gender diversity, audit committees, institutional ownership, and employee pressure has a significant effect on the sustainability report. This research method is a quantitative research by taking samples using a purposive sampling technique based on predetermined characteristics of 20 companies listed in the LQ-45 index for 2019-2022. The type of data used is secondary data and the method of analysis used is panel data regression using Eviews. The results of the study show that the calculation of the hypothesis, namely gender diversity, has no significant effect on the sustainability report with a significant level of 0.5341> 0.05. The audit committee has no significant effect on the sustainability report with a significant level of 0.6224>0.05. Institutional ownership has no significant effect on the sustainability report with a significant level of 0.1466>0.05. Employee pressure has a positive and significant effect on the sustainability report with a significant level of 0.0105<0.05. For simultaneous testing, an F count of 3.812784 is obtained with a probability of 0.000022 <0.05, meaning that gender diversity, audit committee, institutional ownership, and employee pressure simultaneously influence the sustainability report.
Background and Objective A foremost step towards targeted administration of therapeutic agents is the formulation of novel drug delivery systems. Oral route is the most preferred and desired route of administration as a non-invasive mean of transporting drug to a target site. The aim of current research work was to design site-specific hydrogels for target delivery of oxaliplatin, an anticancer agent, used for the treatment of colorectal cancer. Six different types of hydrogel formulations were synthesized by different proportions of polymers and monomers. Another objective was to conduct an oral acute toxicity study of drug carrier polymeric systems on rabbits. Methodology A chemical cross-linking technique, free radical polymerization was chosen for preparation of polymeric networks. Six different combinations i.e. CS-co-poly(MAA), CS-co-poly(AA), PEGMA 4000-co-poly(MAA), PEGA 4000-co-poly(AA), PEGMA 8000-co-poly(MAA) and PEGA 8000-co-poly(AA) hydrogels were fabricated and their response to buffer solutions of different pH i.e. pH 1.2 and pH 7.4 was studied. Cross-linking structure of all formulations were evaluated by Fourier Transform Infrared Spectroscopy (FTIR), scanning electron microscopy (SEM) and X-ray diffraction (XRD). For thermal stability all combination of hydrogels were also subjected to thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) analysis. In-vitro drug release studies of all formulations were carried out in simulated gastric fluids. Moreover, in-vivo analysis of the best formulations was also conducted after the development of HPLC method. The drug release profile was evaluated by the application of zero order kinetics, first order kinetics, Higuchi model and Korsmayer- Peppas model. Oral acute toxicity study was also conducted for four formulations (CSA, CSMA, PEGA 4000, PEGMA 4000) by oral administration of drug carrier polymeric systems to healthy rabbits. Results All results of characterization confirmed the formation of newly developed polymeric hydrogels. Moreover, hydrogels were selected on the basis of their in-vitro studies and subjected to in-vivo evaluation. High performance liquid chromatography (HPLC) method was developed and validated for in-vivo analysis. The study was performed on thirty six xxvii rabbits and liquid-liquid extraction procedure was adopted for isolation of oxaliplatin from plasma samples. The bioavailability and pharmacokinetic parameters were computed by using a software PK Solver Add Inn program. Toxicity study which was conducted on five groups of rabbits, showed no toxic effects on biological systems of newly fabricated polymeric drug delivery systems. Conclusion From findings of our study it could be concluded that among six different cross-linked polymeric networks, PEGA 8000-co-poly(AA) and CS-co-poly(AA) hydrogels could be considered as superior as it showed better in vitro/in vivo release profiles and thus proven suitable for target delivery of Oxaliplatin to a specific site to treat colorectal cancer. Moreover, toxicity studies revealed that developed formulations were non-toxic to the biological system