موت العالِم موت العَالم
متوسلین سلسلۂ مجددیہ نقشبندیہ کویہ معلوم کرکے بڑاافسوس ہوگاکہ حضرت مولانا قاری محمداسحاق صاحب نقشبندی مجددی نے جوحضرت مولانا مفتی عزیز الرحمن صاحب عثمانی دیوبندیؒ کے جانشین اورخلیفۂ مجاز اوراس سلسلہ کے اکابر مشائخ میں سے تھے۔۵؍جولائی ۴۵ء کونماز ظہر کے وقت میرٹھ لال کرتی میں رحلت فرمائی۔ اناﷲ واناالیہ راجعون۔ حضرت مرحوم کے متوسلین سے توقع ہے کہ وہ حضرت مرحوم کی روح پر فتوح کو ایصالِ ثواب کرکے داخل حسنات ہوں گے۔ [ادارہ، جولائی ۱۹۴۵ء]
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Laws of inheritance and succession exist since time immemorial in every human society. The estate of the deceased person is distributed amongst his/her legal heirs according to the laws of inheritance. Based on religions i.e. Islam and Hinduism-two different societies exist in the Indo-Pak sub-continent, having different frames of rules regarding socio-religious life. Coupled with a long history of closeness and co-existence, have deep religio-moral and socio-cultural diffusions and infusions with one another. The same impact permeates the laws of inheritance as well. This paper is an analysis of this permeation by focusing on the points of comparison and contrast in the light of the Holy Qur’ān, Sunn’ah and the sacred books of Hindūism.
In the present work three series of Mannich bases of 1,3,4-oxadiazole-2(3H)-thione (121170) have been successfully synthesized with good to excellent yield and comprehensively characterized by FTIR, 1H-NMR, 13C-NMR, HRMS and elemental analysis. Furthermore, their in-Silico and in-vitro evaluation showed them as excellent urease inhibitors which were even better than standard. All the synthesized compounds were also evaluated for their antioxidant properties as well as antiviral activities against the four poultry viruses (IBA, H9N2 , NDV, and IBDV). The synthetic strategy for the synthesis of these Mannich base derivatives are as under. Synthesis and Biological evaluation of pyrazinyl based derivatives (119-135) The strategy for the synthesis of targeted compounds is elaborated in Scheme 29. Ethyl pyrazine-2-carboxylate (119) was prepared by the esterification of pyrazine-2-carboxylic acid (118), which was further converted into pyrazine-2-carbohydrazide (120) by refluxing with 80% hydrazine hydrate in ethanol. The synthesized hydrazide underwent cyclization to yield 5-(pyrazine-2-yl)-1,3,4-oxadiazole-2-thione (121) upon reacting with CS2 in alkaline medium. Which was then further converted to respective Mannich bases 3-[{(substituted phenyl)amino}methyl]-5-(pyrazine-2-yl)-1,3,4-oxadiazole-2-thione or 5-(pyrazin-2-yl)-3[{(substitutedpyridin-4-yl)amino}methyl]-1,3,4-oxadiazole-2-thione (122-135).