نواب سر مزمل اﷲ خاں بہادر
حاتم یو پی کی وفات
ہمارے صوبہ کے حاتم نواب سر مزمل اﷲ خاں بہادر نے ستمبر کی آخری تاریکوں میں اپنے وطن بھیکم پور ضلع علی گڑھ میں وفات پائی، مرحوم کئی سال سے لگاتار بیمار تھے، بخار اور کھانسی کی تکلیف تھی، ضعف کبھی بڑھ جاتا کبھی گھٹ جاتا، اور آخر اتنا بڑھا کہ پھر نہ گھٹا، چوہتر (۷۴) برس کی عمر میں دنیا کے ہر اُتار چڑھاؤ کو دیکھ کر اور ہر سرد و گرم کو آزما کر دین و دنیا دونوں کی نعمتوں سے بہرہ اندوز ہو کر ۲۸؍ ستمبر ۱۹۳۸ء کو اس ہری بھری دنیا کو الوداع کہا۔
مرحوم شروانی خاندان کے چشم و چراغ تھے، اور جیسا کہ وہ فرمایا کرتے تھے، سرسیدؔ کی گودوں میں کھیل کر جوان ہوئے تھے، عربی و فارسی کی تعلیم پائی تھی، اور انگریزی اتنی جانتے تھے کہ اخبار پڑھ اور گفتگو سمجھ لیتے تھے، فارسی کے شاعر تھے، مرزا سنجر طہرانی سے اصلاحیں لی تھیں، فارسی کا پورا دیوان مرتب تھا، ان کی غزلیں اور نظمیں کئی دفعہ ان کی زبان سے سنیں اور شاید ایک دو دفعہ معارف میں بھی چھپیں، تقریر شگفتہ اور پر مذاق کرتے تھے۔
مولانا شبلی مرحوم کے دوستوں میں تھے، اسی کا اثر یہ تھا کہ وہ مولانا کے کاموں اور تحریکوں سے دلچسپی رکھتے تھے، ندوہ کی طرف ان کا التفات مولانا ہی کے دم قدم اور قلم کے اشاروں سے ہوا، اور دارلمصنفین کی طرف ان کی چشم کرم بھی اسی نسبت کی مرہون ہے، دارالمصنفین اپنی چوبیس برس کی عمر میں حیدرآباد و بھوپال کی سرکاروں کے علاوہ اگر کسی محسن کے فیض سے مستفید ہوا ہے تو وہ بھیکم پور کے رئیس کی ذات تھی، مرحوم نے دارالمصنفین کی مسجد پانچ ہزار کے خرچ سے بنوائی، اور اس...
Aims of Study: From last one decade, advancements in formats of cricket demand agility in the players so that they can play in better way without injury. The aim of this study was to determine which dose of plyometric training is effective to enhance agility in cricket players.
Methodology: Randomized Controlled Trial was registered in US clinical Trial registry (NCT04350385). 40 cricket players were recruited in study, out of which n=20 players were placed in experimental group and n=20 players were in control group. Assessments were taken as baseline and after third week and on sixth week through Illinois Agility Run test, T test and Vertical jump test. Data analysis was done through SPSS version 23. Independent t test was used for between group analysis and paired t test for within group.
Results: Group comparison through T-agility and Illinois test shows significant effect in experimental group (p>0.009). Post intervention Mean±SD of vertical jump test in experimental group was 31.90±2.55 with significant effect (p=0.001).
Limitation and Future Implications: This study can be done on both genders. Players can improve their performance by working on plyometric training and agility.
Originality: This was original work and never published before.
Conclusion: It is concluded from this study that plyometric training is effective in improving agility of the cricket players. Players can improve their performance by working on plyometric training and agility.
This study is done to achieve the aim of formulating microsponges containing CPM alone and in combination with cefexime as API. The microsponge drug delivery system (MDDS) is a porous polymeric system. These are tiny sponge like particles that consist of myriad of interconnecting voids within a non-collapsible structure with a large porous surface through which active ingredients are released in a controlled manner. In this study microsponges are prepared by using Eudragit RS 100 as polymer and PVA as emulsifying agent in different ratios with constant amount of CPM and cefexime. Quasi emulsion solvent diffusion method was used to formulate microsponges. Percentage yield, percent drug entrapment, flow properties including compressibility by Carr’s index, tapped bulk density, loose bulk density, Haunser’s ratio of these microsponges are calculated. From these studies it was shown that percentage yield increased with the increase in the polymer ratio and percentage entrapment was decreased with the increase in the polymer ratio. Results of Carr’s index and Haunser’s ratio indicate excellent flow properties of all microsponges. These microsponges are then characterized by FT-IR and SEM. In-vitro dissolution studies were carried out in USP dissolution apparatus at 50 rpm at 37±0.5 ͦ C. Release kinetic parameters indicated that formulated optimized microsponges were following the korsmeyer peppas release kinetic. All results of physicochemical parameters and characterization values indicate that the optimized CM9 of CPM containing and CCM9 of CPM-CEF containing microsponge formulations will be good for transforming it further into gels and subjected to different evaluation parameters analysis. Then CPM and CPM-CEF entrapped microsponges loaded gels CMG of CM9 microsponges and CCMG of CCM9 respectively by employing Carbopol as gelling agent and Propylene glycol (PG) and Polyethylene glycol (PEG-1000) as permeation enhancing agent. In-vitro studies were executed with the help of USP dissolution apparatus set at revolutions of 60 rpm and at temperature about 37±0.5 ºC. Release kinetic models depicted that formulated microsponges loaded gel was following the first order release model. In Franz diffusion cells, human skin membrane was used to determine the permeation effects. Fick’s laws were employed to compute permeation kinetic parameters such as Flux (J), Permeation Co-efficient (Kp), Diffusion Co-efficient (D), Enhancement Ratios (ER) and Input Rate (IR) of CMG are done. Preformulation studies of both CMG and CCMG were made through Fourier Transform Infrared spectroscopic (FT-IR) records which illustrated absence of any drug-polymer interactions. All physicochemical distinctive features of gel such as viscosity, solubility, spreadability, mucoadhessive force, extrudibility, homogeneity, pH, partition co-efficient (Ko/w), Draize’s skin irritation test and stability studies at 25±0.5ºC and at 40ºC±0.5ºC were calculated. All results demonstrated that the CMG and CCMG will be favorable for further clinical trials evaluations.