Work Fatigue Determination of Nurses in Hospital of Hasanuddin University

This study aims to determine the effect of body mass index (BMI), sleep patterns, working years, physical workload, mental workload, and work time on work fatigue on nurses at Hasanuddin University Hospital Makassar. This research is a quantitative study with a cross-sectional design with a sample size of 56 people. Sampling using a simple random sampling method. Data collection was carried out by means of a questionnaire. Bodyweight is measured by weight scales, body temperature is measured by microtoice, and physical workload is measured by a pulse oximeter, which is by looking at the pulse of the nurse before and after work. Data analysis in this study used the SPSS program. The results of this study indicate that there is an influence between Body Mass Index (BMI) on work fatigue (p = 0.001), there is an effect of sleep patterns on work fatigue (p = 0.019), there is an effect of tenure on work fatigue (p = 0.017), the relationship between physical workload and work fatigue (p = 0.000), there is an effect of mental workload on work fatigue (p = 0.000) and there is an effect of length of work on work fatigue (p = 0.017). The physical workload is the variable with the greatest influence on work fatigue on nurses at Hasanuddin University Hospital Makassar with Exp. (B) = 14,526. The results of this study concluded that there was a significant influence between the Body Mass Index (BMI), sleep patterns, years of work, physical workload, mental workload, and length of work for nurses at Hasanuddin University Hospital Makassar.

Screening of Beta Vulgaris for Pharmacological Actions

Beta vulgaris, commonly known as beetroot, has been used as a dietary ingredient since traditional times. It is consumed not only in cooked form, but in raw form too. Now adays, it is also being used as juice. Literature review has shown that Beta vulgaris (beetroot) possesses a lot of therapeutic potential and might be used as an anti-microbial, anti-carcinogenic, anti-oxidant, to treat hypertension and to boost immunity. This study was designed to evaluate the pharmacological actions of different doses of lyophilized beetroot. Studies were established to generate awareness and improve our knowledge regarding the benefits of different doses of beetroot on anxiety, depression, memory and CNS disorders. Effect was further verified by determination of brain biogenic amines using HPLC. Different doses of beetroot were also evaluated for effect on pain and inflammation. Their effect on hematological parameters, liver, kidney, thyroid, lipid, electrolyte and reproductive hormones profile were also observed. We also checked the diuretic effect of both doses on rats, as well as set up the fertility model in mice. Phytochemical analysis was carried out too. Results showed positive anxiolytic and anti-depressant potential at both doses. Memory was dosedependently enhanced and both doses showed improved effects in seizure model, catatonia model and Alzheimer model. Histopathology showed there was absence of pathological findings when the rodent brain was observed. Increase in RBC’s and Hb was observed for both doses where as WBC’s were in normal range. Coagulation parameters showed positive effect for both doses too. Liver profile, kidney profile and thyroid profile showed reduction in level of enzymes and hormones when compared with control. Lipid profile also showed decrease in levels when compared with control. Hyperlipidemia model also showed positive effects for both doses. Analgesic and anti-inflammatory effects were observed for both doses of beetroot. Electrolyte profile was in normal range for both doses. Diuretic profile was observed for both doses. The number of pups were increased dose-dependently when Beta vulgaris was given in fertility model. The pups born had no birth defects, behavioral abnormalities or growth deficiencies. Positive effects on reproductive hormones were observed for both doses. Phytochemistry revealed the presence of carbohydrates, tannins, flavonoids, saponins, cardiac glycosides, phenols, terpenoids and anthraquinones. Both doses of Beta vulgaris (500mg/kg and 1000mg/kg) showed positive results with mild variations. Further studies can be carried out to establish the exact molecular mechanism of action and to study the effect of lyophilized powder in clinical trials especially in Alzheimers patients.