حدیثِ خواب گویم
سفر نامے کے بنیادی لوازمات میں سے ایک سفر بھی ہے ۔جب کہ اس میں برتی جانے والی پابندیوں میں سب سے اہم فسوں گری اور مبالغے سے اجتناب ہے۔ یہ لوازمات اور پابندیاں کسی اور ملک کے سفر پر نکلے سفر نامہ نگار کے لیے زیادہ مشکل نہ ہوں مگر سفر اگر مصر کا ہو تو سفر نامہ نگار کے لیے یہ دو دھاری تلوار پر چلنے سے کم نہیں۔
مصری تہذیب کی حقیقت جس قدر مسلمہ ہے اس قدر فسوں آمیز۔ یہاں کے نظارے اس حد تک تحیر آمیز ہیں کہ ان پر بات کرنی اور اس پر تحریر کرتے وقت طلسماتی ارتعاش اور فینتاسی سے خود کو الگ کرنا ممکن ہی نہیں ہوتا۔
فوق الفطری ماحول اور فضا، قصہ در قصہ بنیادی حقیقت اور واقعے کے ساتھ ضمنی کہانیاں ،غیر مرئی حقیقت ،انسانوں کے علاوہ جانوروں اور چرند پرند سے منسلک واقعات، مرکزی کرداروں کی غیر معمولی طاقت اور حیثیت ،معاون کرداروں کی فوجِ ظفر موج، مشکلات، رکاوٹوں کاذکر، مذہبی اور دینی عقاید و تجربات ،آسمانی اور انسانی قوانین کا ذکر اور نفاذ غرض وہ تمام لوازمات جو کسی افسانوی تحریر کے خاصے ہوتے ہیں ، مصر پر لکھے سفر نامے کے بنیادی شرائط و لوازم بن جاتے ہیں۔
ان ہی لوازمات کی وجہ سے سفر نامہ داستان اور فسوں گری کا لبادہ اوڑھ لیتا ہے۔ لکھاری تہذیبی، تاریخی اور ذاتی داخلیت کا شکار ہو جاتا ہے۔ مسافر کے ساتھ بھی اس سفر پر کچھ ایسا ہی ہوا۔ جہاں بھی گیا حقیقتیں، حسین تخیل اور سچائیاں فینتاسی کا روپ دھار لیتیں، چاہے یہ حقیقتیں فراعینِ مصر کی ہوں یا یہ سچائیاں وادیٔ سینا کی طلسماتی فضا کی ہوں جہاں ریب و تکذیب کی گنجائش نہ ہوتے ہوئے بھی میری فکر افسوں اور بالعکس فسوں کے ساتھ ابہام و سحر کی خواب...
The action code of Islam is impartial and strong. All human beings, disabled and abled have the right of gaining justice and bound to giving justice. Because of disableness impartial behavior is against the Islamic justice code. The “good behavior” with disabled persons is the basic law of disableness in Islam. The “good behavior” with disabled persons in Islam is not the result of mercy and pity but is the result of that right of taking equal to the life of common people which is due to the nation and community. Hence the rights of disabled persons are the result of those requirements which are created due to disableness. The meaning which we take conventional is “complete worthlessness” but it means in Islam weak and feeble. That is to say disable person is able to work but he has less ability. Or he has no ability to do one job but has the ability of high rank to do other jobs. The Holy Prophet (Peace be upon him) introduced first time this principle of disableness. The Arabs mean the word “disableness” complete uselessness. But the Holy Quran exempted the persons from Jehad not taking part in Tabuk battle because of disableness giving them the name of feebles. Islam does not appeal for mercy with disabled persons but advised to behave well with them and condemns also the injustice of society with them. Islam orders to perform one’s duties to others. Islam not only stresses on the performance of duties but also gives instructions in this connection.
Intellectual disability is a neurodevelopmental disorder with 1-3 % prevalence in the world population and characterized by limitations in intellectual functioning and adaptive skills with intelligence quotient (IQ) below 70 and inception before 18 years age of an individual. Molecular basis of intellectual disability in Pakistani population is not well studied and present study was designed to fill the gaps in the current knowledge of causative genes/loci responsible for intellectual disability in Pakistani population. This study is part of an institutional project on intellectual disability being executed in “Genetic Diseases lab” of the Centre of Excellence in Molecular Biology (CEMB). Forty five families with two or more affected individuals segregating intellectual disability were ascertained from Punjab province. For confirmation of genetically transmitted intellectual disability and exclusion of environmental causes, complete medical history of affected individuals and their family was documented and written informed consents were obtained. Twenty six consanguineous families, predominantly first cousin marriages, were selected for further study and screened for exclusion of twelve already reported intellectual disability loci. Three families, designated as PKMR173, PKMR 228 and PKMR 116 were found to be linked with MRT11, MRT10/20 and MRT23 respectively. Next generation sequencing/high throughput sequencing was carried out on chromosomal DNA of the affected and one unaffected member in the remaining i.e. unlinked families. Novel mutations in genes already associated with intellectual disability or related disorders were found in four families. A missense mutation in gene WDR73 segregated with phenotype in PKMR242 resulting in amino acid change of (p.(Phe325Ser)) and a missense mutation in protein FRY segregated with phenotype in PKMR264 with amino acid change of (p.(Val761Ile)). A nonsense mutation in GPT2 segregated in PKMR 281 with an amino acid change of (p.(Arg404*)) and a missense mutation in FLNA segregated in PKMR 321 with an amino acid change of (p.Thr1685Met)). Genome wide scan on DNA in family PKMR 177 resulted in mapping of a 34.5 Mb long novel locus along with frameshift mutation in a novel gene SYNRG on chromosome 17p11.2-q22 with maximum two point LOD score (Zmax) of 2.8 at recombination fraction θ=0. This novel region was also found in four other families PKMR15, PKMR 65, PKMR 72 and PKMR 274, however, causative gene was different in additionally linked families. Another 23.95 Mb long novel region was mapped in PKMR 225 on chromosome 6p23-p21.2 with moderate to severe level of intellectual disability. Two potential novel regions of 1.36 Mb and 32.58 Mb length, were mapped in PKMR 165 loop-1 and loop-2 on chromosome 9q31.3-q33.2 and chromosome 3p24.1-p14.2 respectively. In PKMR 199 three potential candidate regions were mapped on chromosome 6q24.1-q24.3, 8q24.13 q24.21 and 20p12.3 of 0.47 Mb, 0.16 Mb and 12.9 Mb respectively. In conclusion, this study is a significant contribution in identification of causes of intellectual disability in Pakistani population and will help to devise strategies to combat with this disorder in a well-organized way. This study is also expected to enlarge the current repository of genes/loci in Pakistani population.