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Differences between Supervisors' and Subordinates' perception of Job Definition in Mobile Organization

Thesis Info

Author

Zeeshan Daud

Department

Department of Management Sciences

Program

Mphil

Institute

National University of Modern Languages

Institute Type

Public

City

Islamabad

Province

Islamabad

Country

Pakistan

Thesis Completing Year

2013

Subject

Management Sciences

Language

English

Added

2021-02-17 19:49:13

Modified

2024-03-24 20:25:49

ARI ID

1676728778615

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Telecom sector of Pakistan has a rapid growth rate in last few years. One of the problems being faced by mobile organizations is high rate of employees’ turnover. This study analyzes the perception of supervisors and subordinates on job definition of mobile organizations with relationships to turnover intent. Supervisor perception about the subordinate’s job and subordinates perception about their job. In addition, factors which affect the relationship between two sides are also analyzed. One hundred and ninety supervisors and subordinate employees of major mobile organizations were surveyed. The measurement included perception of job definition, supervisors attributes on subordinates job performance, subordinates attributes towards their job and supervisors attitude towards subordinates job description. One hundred and sixty questionnaires were distributed to supervisors and their respective subordinates and one hundred and forty were returned back. Univarite analysis ANOVA was used to find the relationship of eleven hypotheses of the study. Multivariate analysis was also performed on relationship of JDPI and tangible and in tangible satisfaction with turnover intent. Statistical package SPSS 17.0 was used. The study and analysis discovered that there are perceptional differences between supervisors and their respective subordinates. 55% subordinates’ think that their relationship with supervisors are not friendly and they are overload at workplace. 69% supervisors think that subordinates take more time to perform different tasks and give more priority to trivial matters of the job. In addition more than 50% supervisors perceive that most of their subordinates are classic squeaky wheel that needs always greasing. Furthermore 64 % subordinates think that they can easily adjust in any other organization, this shows their belongingness to their organizations and it would be critical for the mobile organizations.
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احمد ندیمؔ قاسمی

احمد ندیمؔ قاسمی کی رحلت
مشہور ترقی پسند ادیب و شاعر جناب احمد ندیم قاسمی طویل عرصے سے اردو کے افقِ شعر و ادب پر ضوفشاں تھے، افسوس ہے کہ ۱۰؍ جولائی کو وہ وفات پاگئے، اناﷲ وانا الیہ راجعون۔
انہیں پھیپھڑے کی تکلیف اور تنفس کا عارضہ پہلے سے تھا، اس بار دل کی بیماری میں مبتلا ہوئے اور لاہور کے پنجاب انسٹی ٹیوٹ آف کارڈیالوجی میں بڑی نگہ داشت والی یونٹ میں داخل کیے گئے تھے لیکن بیماری دل نے کام تمام کردیا اور اردو زبان نے اپنا ایک قد آور ادیب و شاعر، بڑا افسانہ نگار اور ممتاز صحافی اور کالم نگار کھودیا۔
ان کا اصل نام احمد شاہ تھا لیکن دنیائے شعر و ادب میں احمد ندیم قاسمی کے نام سے معروف ہوئے، وہ مغربی پنجاب کی وادی سون سیکسر کے گاؤں انگہ ضلع خوشاب میں ۲۰؍ نومبر ۱۹۱۶؁ء کو پیدا ہوئے تھے لیکن ان کے فکر و عمل کی جولان گاہ لاہور تھا اور یہی آخر میں ان کا مدفن بھی بنا۔
احمد ندیم قاسمی پنجاب یونیورسٹی سے گریجویشن کرنے کے بعد جلد ہی صحافت کے میدان میں وارد ہوئے، اس میں ان کا جوہر خوب کھلا، ان کا تعلق درجنوں اخبار اور رسائل سے رہا، ۱۹۴۳؁ء سے ۱۹۴۵؁ء تک ’’ادب لطیف‘‘ سے منسلک تھے، ۱۹۴۷؁ء میں ’’سویرا‘‘ کی ادارت سنبھالی، نقوش میں بھی اپنا نقش چھوڑا، امتیاز علی تاج کے رسالے ’’پھول‘‘ اور ’’تہذیب نسواں‘‘ سے وابستہ ہو کر ادب اطفال اور نسائی ادب میں اپنا سکہ جمایا، ’’امروز‘‘ ترقی پسند تحریک کا آرگن تھا، اس میں ’’پنچ دریا‘‘ کے نام سے فکاہی کالم لکھ کر اپنی خوش طبعی اور بذلہ سنجی کا ثبوت دیا اور کالم نگاری میں امتیازی درجہ حاصل کیا، وہ اس میں پنجاب کے مشہور صحافی عبدالمجید سالک کو اپنا استاد مانتے تھے، بعد میں وہ اس...

Optimizing Character Education for Adolescents Plagued by Free Intercourse

Adolescent character education is extremely important. Promiscuity, rampant rates of aggression against children and youth, robberies against peers, juvenile theft, cheating behaviors, substance addiction, pornography, and the misuse of others' property have all been global issues that have yet to be fully addressed. The article explains the philosophy of adolescent character education, the function of adolescent character education, the urgency of adolescent character education, the factors that affect character education, and the enhancement of adolescent character education for adolescent promiscuity. Attitudes, emotions, will, values, and behaviors are all ingredients in the definition of character education for teenagers.

Formulation Development and Invitro Estimation of Bilayer Tablet of Nicorandil 80 Mg and Atorvastatin 20 Mg

Bilayer tablet formulations containing immediate release layer and sustained release layer has gained substantial attention among researchers and in pharmaceutical industries. Bilayer tablets have various advantages in contrast to conventional tablets and can surmount the limitation observed in single layer tablet. Cardiovascular diseases extensively cover hypertension and ischemic heart diseases that requires blood pressure monitoring. High blood pressure is one of the biggest contributors of global death. Furthermore, high serum cholesterol and elevated low density lipoprotein are important risk factor associated with cardiovascular disease. Combination formulations of anti-hyper-lipidemic agents and antihypertensive agents minimized various hypertensive symptoms of hyper-lipidemic patients. It has been reported that two or more drug given in combined form has been found to be more effective in multiple therapies than single drug and provides patient compliance. In some cases, combination drugs are available as single pill proving to be less expensive and convenient in long term treatment and saves person time and effort in their daily routine. The objective of the present study is to develop bilayer tablet of sustained release layer of nicorandil 80 mg and immediate release layer of atorvastatin 20 mg using double compression technique. Sustained release nicorandil formulations were developed and optimized by direct compression method using different hydrophilic and hydrophobic polymers. Nicorandil is a novel compound associated with the class of potassium channel activators employed for the management of cardio vascular ailments such as hypertension and angina pectoris. Nicorandil has a short half-life and the usual oral dosage regimen is 5 to 40 mg taken 2 to 4 times a day. Pharmaceutical literature reviews has repeatedly emphasized therapeutic and pharmacological benefits of controlled release dosage forms of compounds with short half-lives. One of challenge to researcher is to develop highly water soluble drug sustained release dosage form which can release constantly at a definite rate. Successful treatment of cardiovascular diseases can be accomplished through blood pressure maintenance at a normal physiological level that requires steady and consistent supply of drug. Recurrent dose administration at intermission of 6 to 8 hours is problematic for a hypertensive patient or a patient with angina, ultimately leads to patient nonconformity. Nicorandil with all evident advantages proved to be a suitable candidate for development of a controlled-release dosage form because of relatively small daily dose, short half-life and rapid absorption from the GIT. Therefore, once daily nicorandil sustained release formulation is needed that requires drug to be released constantly throughout twenty four hour period. Atorvastatin calcium is a BCS class II drug used as a lipid lowering agent. In the present study, nine different immediate release atorvastatin formulations was developed using central composite design. Formulations were prepared through incorporation of superdisintegrant crospovidone along with sodium carbonate as an alkalizer that can facilitates drug solubility and hence drug dissolution. Nicorandil sustained release formulations were developed through direct compression method. Central composite design was used for developing nine different formulations using different hydrophilic and hydrophobic polymers combination. Formulations F1-F9 comprised of polyox and ethyl cellulose polymer combination. Formulations F10-F18 consisted of HPMC K100M and eudragit® and F19-F27 formulations included HPMC K100M and ethyl cellulose as hydrophilic and hydrophobic polymers. Response surface graphs were plotted with design expert® software version 7.0.0 to assess the effect of different polymer combination in formulation on dependent variables such as disintegration and dissolution at 2 hours and 12 hours. Pre-compressional and post compressional pharmacopoeial and non-pharmacopoeial test parameters were applied to ensure compressed tablets quality. Micromeritic evaluation, FT-IR studies and blending time was determined. Micromeritic results showed that powder blends complying the B.P standard categorization of passable to excellent were selected for formulation development by direct compression method. FT-IR studies were also performed and nicorandil showed no interaction. Blending time was found to be 9 minutes. Formulation F3, F6, F9, F11, F17, F18, F20, F26 and F27 formulations showed better results among their respective formulations. Drug content was found to be within pharmacopoeial limit as determined by developed and validated method. Swelling studies for all the nicorandil sustained release formulations were determined and it was found that formulation that contained less percentage of HPMC as demonstrated by F14 containing HPMC-eudragit® combination and F21 and F23 formulations that composed of HPMC-EC combination swelled less. Dissolution profile was studied in phosphate buffer at pH 4.5, pH 6.8 and 0.1 N HCl (pH 1.2). An efficient sustained release formulation preferably must release drug content at determined time period to attain desired level in plasma. Theoretical release profile determination is one of the important aspects to ascertain release at a definite rate in a reproducible manner. The dissolution study of formulation F18 and F20 showed sustained-release pattern was comparable to theoretical release profile. DDSolver® excel based Add in program was used for the application of model dependent and independent approach to the dissolution profile. Formulation F20 was considered as reference owing to its best physicochemical attributes. All the formulations were found similar to formulation F20 except formulations F1, F5, F7, F10, F14 and F25 were found dissimilar in contrast with formulation F20. The sustained release nicorandil formulations showed release kinetics that was best fitted for Higuchi model for all sustained release nicorandil formulations. For the confirmation of release mechanism, the dissolution profile was fitted to Korsmeyer equation. The regression values indicated that drug release followed anomalous drug release kinetics among all formulations. The selected formulations were subjected to long term stability testing at 25°C/60% RH for duration of 12 months and accelerated studies at 40°C/75% RH for duration of 6 months according to ICH guidelines. Selected formulations physicochemical attributes were determined for the determination of most stable formulation. Long term stability results showed F6, F18 and F20 represent a shelf life of 17.85, 17.56 and 17.4 months using Minitab®17.1.0 software and accelerated stability studies showed good pharmaco-technical attributes and proved as the best designed formulation having shelf life of 12.05 months, 13.164 months and 13.776 months respectively. Therefore, formulation F18 and F20 can be considered as most stable and optimized formulation. Immediate release atorvastatin formulation development through central composite design using crospovidone (1.37-5%), sodium carbonate (1.58-4.41%) along with magnesium stearate 2% and avicel was added to attain a tablet average weight of 150 mg. Micromeritic evaluation, FT-IR studies and blending time were carried out. Physicochemical attributes of the developed formulation were determined as per pharmacopoeial standard that includes tablet hardness, weight variation, disintegration, diameter variation, friability and assay. All formulation had a disintegration time of less than 1 minute. Formulation A7 failed hardness test. Dissolution profile study was performed on pH 1.2 and phosphate buffer at pH 4.5 and pH 6.8. DDsolver® excel based Add in program was used for the application of model dependent and independent approach to the dissolution profile. It was found that formulation A6, A8 failed f2 test in pH 1.2 while A2 failed f2 test in all pH. Formulations A1, A3, A5, A7 and A9 were found similar to market innovator brand M1 in all pH. The lowest mean dissolution time (MDT) values were shown by formulation A1and A3 and A9 owing to the presence of higher proportion of superdisintegrant. Furthermore, those formulations containing lesser proportion of superdisintegrant corresponds to higher MDT values as is the case of A2 formulation. % DE was applied to all immediate release atorvastatin formulation and it was found that A2 and A6 did not comply %D.E test in pH 1.2 while all formulations were considered equivalent to innovator brands as difference of dissolution efficiency is within desired limit. Model dependent studies result showed that the dissolution release followed First order and Weibull model kinetics. The long term and accelerated study were carried out as per ICH guide lines. Different physicochemical parameters such as friability test, disintegration test, % drug release, hardness test and % assay for selected atorvastatin immediate release formulations was determined according to pharmacopoeial standards. The shelf life of selected formulations when subjected to long term stability was in the range from 20-23 months using Minitab®17.1.0 software. The estimated shelf life of selected formulations A1, A3, A5 and A9 after accelerated studies was in the range from 15 - 23 months. A9 was considered to be most stable formulation among selected formulation owing to longer shelf life. Bilayer tablet of nicorandil and atorvastatin was developed from the optimized formulation of sustained release nicorandil (F18 and F20) and immediate release atorvastatin (A9) formulations. Therefore, two bilayer tablets were formulated, B1 formulation contained immediate release layer of atorvastatin (A9) and sustained release nicorandil layer (F18) and B2 bilayer tablet was prepared with immediate release atorvastatin layer (A9) and sustained release nicorandil layer (F20). Both of the optimized formulations powder containing API and excipients were blended separately and their bilayer tablets were prepared through double compression technique. Assessment of physicochemical attributes of bilayer tablet was determined using pharmacopoeial standards. Accelerated stability studies on the developed formulation was performed and the study result revealed that formulation B1 and B2 complied with all standard requirement but formulation B2 was preferred from economic point of view. In present research a reproducible, robust, simple high performance liquid chromatographic method was developed for assessment of nicorandil and atorvastatin in bulk and combined dosage form utilizing Waters Spherisorb® column (4.6×200 mm, 10 μm ODS), acetonitrile: phosphate buffer (pH 4.5) in proportion of 55:45 as a mobile phase with flow rate of 1ml/min and discreet peaks were identified using UV–VIS detector at 262 nm. Method validation encompasses parameter such as specificity, system suitability, linearity, accuracy, precision, limit of detection and limit of quantification were determined. The calibration curves for nicorandil and atorvastatin demonstrated an excellent linearity with R2 = 0.9999 in range of 0.3125-80 μg/ml and 0.156-80 μg/ml respectively. The developed and validated method showed satisfactory accuracy and precision characteristics. The developed method short run time (7 minutes) with the with the with the with the with the with the retention time of approximately 3 minut retention time of approximately 3 minut retention time of approximately 3 minut retention time of approximately 3 minut retention time of approximately 3 minut retention time of approximately 3 minut retention time of approximately 3 minutretention time of approximately 3 minut retention time of approximately 3 minut retention time of approximately 3 minutretention time of approximately 3 minut retention time of approximately 3 minut retention time of approximately 3 minutretention time of approximately 3 minutretention time of approximately 3 minut retention time of approximately 3 minut retention time of approximately 3 minut es (mean ± SD=3.047 0.119) for nicorandil and es (mean ± SD=3.047 0.119) for nicorandil and es (mean ± SD=3.047 0.119) for nicorandil and es (mean ± SD=3.047 0.119) for nicorandil and es (mean ± SD=3.047 0.119) for nicorandil and es (mean ± SD=3.047 0.119) for nicorandil and es (mean ± SD=3.047 0.119) for nicorandil and es (mean ± SD=3.047 0.119) for nicorandil and es (mean ± SD=3.047 0.119) for nicorandil and es (mean ± SD=3.047 0.119) for nicorandil and es (mean ± SD=3.047 0.119) for nicorandil and es (mean ± SD=3.047 0.119) for nicorandil and es (mean ± SD=3.047 0.119) for nicorandil and es (mean ± SD=3.047 0.119) for nicorandil and es (mean ± SD=3.047 0.119) for nicorandil and es (mean ± SD=3.047 0.119) for nicorandil and es (mean ± SD=3.047 0.119) for nicorandil and es (mean ± SD=3.047 0.119) for nicorandil and 5.37 minutes (mean ± SD=5.373 0.209) for atorvastatin 5.37 minutes (mean ± SD=5.373 0.209) for atorvastatin 5.37 minutes (mean ± SD=5.373 0.209) for atorvastatin 5.37 minutes (mean ± SD=5.373 0.209) for atorvastatin 5.37 minutes (mean ± SD=5.373 0.209) for atorvastatin5.37 minutes (mean ± SD=5.373 0.209) for atorvastatin5.37 minutes (mean ± SD=5.373 0.209) for atorvastatin 5.37 minutes (mean ± SD=5.373 0.209) for atorvastatin 5.37 minutes (mean ± SD=5.373 0.209) for atorvastatin 5.37 minutes (mean ± SD=5.373 0.209) for atorvastatin 5.37 minutes (mean ± SD=5.373 0.209) for atorvastatin 5.37 minutes (mean ± SD=5.373 0.209) for atorvastatin 5.37 minutes (mean ± SD=5.373 0.209) for atorvastatin 5.37 minutes (mean ± SD=5.373 0.209) for atorvastatin 5.37 minutes (mean ± SD=5.373 0.209) for atorvastatin 5.37 minutes (mean ± SD=5.373 0.209) for atorvastatin 5.37 minutes (mean ± SD=5.373 0.209) for atorvastatin 5.37 minutes (mean ± SD=5.373 0.209) for atorvastatin 5.37 minutes (mean ± SD=5.373 0.209) for atorvastatin and less injection volume (20 μl) enables the method‘s successful utilization in QA/QC laboratories. The pharmaceutical equivalence of different nicorandil and atorvastatin tablets available locally were purchased from local store of Karachi. Brand A was considered as innovator brand for nicorandil and M1 was selected as reference brand for atorvastatin due to its excellent physicochemical attributes as per pharmacopoeial standard. Quality attributes such as diameter, hardness, thickness, weight variation and friability were analyzed as per pharmacopoeial standard. Marketed brands showed acceptable result as per pharmacopoeial standard. Dissolution profile was studied at 0.1 N HCl (pH 1.2), phosphate buffer at pH 4.5 and pH 6.8. Model dependent and independent method was carried out using DDSolver® excel based add in program for analysis for dissolution profile. In case of nicorandil, all brands except brand D passed f1, f2 test and %D.E was within acceptable limit of ±10% in all three dissolution medium while in case of atorvastatin M5 and M6 passed f1, f2 test and their difference in %D.E was within ±10% in all three FDA recommended dissolution medium. Nicorandil and atorvastatin release kinetics followed First order release kinetics. Hence, only brand D from nicorandil brands does not complied with pharmaceutical quality test while M5 and M6 atorvastatin brands was found to pharmaceutically equivalent to innovator brand and can be used interchangeably." xml:lang="en_US