ڈاکٹر حفیظ سید مرحوم
افسوس ہے کہ ہماری علمی بزم کی ایک پرانی یادگار ڈاکٹر حفیظ سید مرحوم نے گزشتہ مہینہ انتقال کیا ان کی پوری زندگی تعلیمی اور علمی مشاغل میں گزری اور آخر میں الٰہ آباد یونیورسٹی کی اردو کی پروفیسری سے ریٹائرڈ ہوئے تھے، وہ مشہور صاحب قلم تھے اردو، انگریزی دونوں زبانوں میں سیکڑوں مضامین، ان کی یادگار ہیں مستقل کتابوں میں مشہور دکنی شاعر قاضی محمود بحری کا کلیات تصحیح و ترتیب کے جملہ لوازم کے ساتھ مرتب کرکے شائع کیا تھا، ان کو تصوف اور روحانیات سے خاص دلچسپی تھی، اس ذوق میں انھوں نے مختلف مذاہب کے روحانی مرکزوں اور ان کی روحانی شخصیتوں سے بھی استفادہ کیا تھا مگر آخر میں اپنے اصلی مرکز کی طرف لوٹ آئے تھے اور اسی پر ان کا خاتمہ ہوا، مرحوم علامہ شبلی کے صحبت یافتہ اور ارکان دارالمصنفین کے پرانے رفقاء میں تھے، اس لیے دارالمصنفین سے ان کو دیرینہ مخلصانہ تعلق تھا، اس کی مجلس عاملہ اور مجلس انتظامیہ کے رکن بھی تھے، ادھر کئی سال سے فالج میں مبتلا تھے، گذشتہ مہینہ آنکھ کھلوانے کے لیے سیتاپور گئے تھے، وہیں دفعتہ انتقال کیا اور الٰہ آباد میں تجہیزوتکفین ہوئی۔ اللھم اغفرْلہٗ وَ ارْحمَہٗ۔ (شاہ معین الدین ندوی، جنوری ۱۹۶۲ء)
Dr. Najeeb Al-Kailani is considered one of the most famous writers who enrithed the library of Islamic Literature. He has written around forty novels, seven collections of short stories, three dramas, and fives Diwans, apart from the many critical studies in the field of Islamic Literature. It is not possible to ignore the status of AI-Kailani and his eminence in the field which he has tackled. The novels which he has produced revolve round several points: >_ In his early novels he presented different aspects of the real life in Egypt. His work also include the novels which picturize the problems of the Muslims outside the Arab World, like Central Asian States, China, Ethiopia, Indonesia, and Nigeria. They also deal with the contemporary issues related to Muslims like the reformation of the society, bringing out the disturbances with all its shapes and its remedy by inviting the people with good means and Islamic values. X. r. i. They deal with Islamic History and Seerah of the Holy Prophet (PBUH) and his guided Caliphs
A combinatorial synthesis of small libraries of a variety of amino chalcones has been carried out in solution phase under standard Claisen Schmidt conditions. The compounds were tested for their potential as antibacterial and cytotoxic agents as well as phosphatase inhibitors and the leads were identified in each bioassay. Chalcone 7 was found to have strongest potential as cytotoxic agent, while chalcone 11 be the most potent PGM inhibitory agent. Parallel synthesis of a 120 member chalcone library was carried out as mixture synthesis following the positional scanning protocol. The identification of lead in this library was carried out by deconvulution and chalcones 22 and 41 were found to be the most potential candidates to be developed as antibacterial agents. Following the same strategy of mixture synthesis, another 175 member chalcones library was synthesized and most potent anticancer chalcones 31, 61 and 78 were identified by deconvolution through position scanning protocol. Peptidyl α,β- unsaturated ketones were synthesized as novel bis- electrophiles susceptible for 3+2 and 3+4 annulations. As a result, peptidyl oxazoles, pyrazolines, pyrazoles, benzothiazepines and benzodiazepines were synthesized. Potent antidiabetic chalcones were docked into the PGM active site and a rationale was found for greater antidiabetic activity of chalcones over the other. Rational design and synthesis of some cytotoxic chalcones was based on 3DQSAR studies using CoMFA as a tool. 3DQSAR studies were also carried out on a library of 30 chalcones as potential antitumor agents.