دولت ہے جس کے پاس وہی باکمال ہے
نحمدہ ونصلی علی رسولہ الکریم امّا بعد فاعوذ بااللہ من الشیطن الرجیم
بسم اللہ الرحمن الرحیم
معزز اسا تذہ کرام اور میرے ہم وطن ساتھیو!
آج مجھے جس موضوع پر لب کشائی کا موقع مل رہا ہے وہ ہے:’’دولت ہے جس کے پاس وہی با کمال ہے ‘‘
صدرِذی وقار!
ہر انسان خواہ غریب ہو یا امیر ہو، خواہ وہ چیتھڑ وں میں ملبوس ہو یا اس نے خلعتِ فاخرہ زیب تن کی ہو، خواہ وہ سیاہ فام ہو یا سرخ رو ہو، خواہ اس کا قد چھوٹا ہو یا مناسب قد و قامت کا مالک، ہر ایک کو اشتیاق ہے کہ وہ کمال حاصل کرے ، اور اعلیٰ سے اعلیٰ مراتب پر فائز ہوجائے ،ترقی کے مدارج طے کرتا ہوا ثریّا تک پہنچ جائے۔
کسبِ کمال کُن کہ عزیز جہاں شوی!
جنابِ صدر!
معلم کا کمال یہ ہے کہ تدریسی میدان کا شاہسوار ہو،زیرِتعلیم طلباء کی رہنمائی کے لیے مہارت تامہ کا حامل ہو، اپنے مضمون پر مکمل دسترس رکھتا ہو، اس کا ہر سال رزلٹ %100 رہتا ہو، اُس مدرسہ کی نظر میں کامیاب مدرس ہو، خصائل صالحہ کا مجسمہ ہو، تدریسی مہارتوں کے استعمال میں اُسے ید ِطولیٰ حاصل ہو۔
جنابِ والا!
خطیب کا کمال یہ ہے کہ اس کا خطبہ معیاری ہو۔ فرقہ واریت سے پاک ہو، اس کی بیان کردہ روایات حشوو زواید سے پاک ہوں۔ اس کی زبان میں روانی ہو، اور حسنِ صورت کے ساتھ ساتھ حسنِ سیرت کا بھی مالک ہو۔ اس کے پر تاثیر بیان سے تمام سامعین برابرمتمتع ہوں۔
صدرِمحترم!
معلم کمال کی بلندیوں کو چھو سکتا ہے ،مقنن کا طائرکمال فضاء کی بلندیوں میں پرواز کرسکتا ہے۔ خطیب کی ترقی و عروج کی عندلیب گلشن کمال و مراتب رفیعہ میں مسحورکن نغمے آلاپ...
Employees are the precious assets of organizations and play a vital role in success or failure of any organization. Job security is one of the main goals of employees in Pakistan. It is also considered one of the important factors for job attitude. As it has been considered and supported by researches that job security creates job satisfaction and job satisfaction has positive relationship with performance. This research explored relationship between job security and job performance of employees in organization. The sample consists of 60 employees from nine organizations of District Badin (Private, Public & NGOs), convenient sampling technique was used. Close-ended Questionnaire was divided in two portions, the first portion comprises on 6 items about job security that was filled by employees, and the second portion consists of 15 items about job performance and was filled by their bosses afterward. Data was analyzed using SPSS 22.0 in terms of Descriptive Statistics and Pearson Correlation. Non-confirmed employees are performing better as compared to confirmed employees due to fear of loss of job at any time as they believe that performance causes to get a job secured. Results demand for serious consideration about motivation, evaluation, confirmation and probation policies in organizations.
OBJECTIVE: To study the capability of bioactive compounds to ameliorate the neuronal destruction in animal model of Parkinson disease. MATERIALS AND METHODS:Rotenone was used to produce the Parkinsonism in mammalian model of rats and the bioactive compounds, chrysin, polydatin and CGA were used to ameliorate the neuronal destruction and the resulting effets of Parkinson in this study. A total of hundred male Sprague Dawley albino rats of weight 200 to 250 gm were divided randomly into five groups with twenty animals in each: control, rotenone+chrysin, rotenone+polydatin and rotenone+chlorogenic acid (CGA) group. Rotenone was dissolved in DMSO and migloyl 812 N at ratio of 2:98 respectively and was administered intraperitoneally at a dose of 3 mg/kg, daily for four week to produce the rat model of Parkinson disease. Mortality and weight changes were assessed, various behavioral tests were performed throughout the experiment to assess the neuro behavioral changes. At the end of experiment, animals were sacrificed, brains were fixed by perfusion method and light microscopic sections were prepared using H & E and cresyl violet method. Immunohistochemical sections were also prepared using anti tyrosine hydroxylase antibody, anti α synuclein antibody, anti ubiquitin antibody, to localize the damaged neurons and amelioration done by bioactive compounds. Anti GFAP antibody was used to localize the Astrocytes immunohistochemically. Dopaminergic neurons, α synuclein and ubiquitin aggregations and astrocytes were analysed for anychanges in their morphology and count in substantia nigra and striatum in Parkinsonism and the ameliorating effects of the bioactive compounds used in this study on them. RESULTS:Rotenone-induced Parkinsonism in animals showed a significant loss of body weight and increase in mortality.Parkinson animals showed deteriorating motor behaviour over the period of experiment. Parkinson animals showed a decrease in dopaminergic neurons in nigrostriatal region. TH immunohistochemistry (IHC) showed decreased immunoreactivity and number of TH positive dopaminergic neurons.Ubiquitin and α-synuclein IHC showed accumulation of α-synuclein & ubiquitin within the neuronal cytoplasm. Astrogliosis with increase in number and amoeboid morphology was also seen. Bioactive compounds not only significantly restored the rotenone-induced weight loss but also the behavioural changes. These compounds also showed protective effects in terms of less degeneration of nigrostriatal dopaminergic neurons and diminished immunoreactivity to anti ubiquitin and anti α-synuclein antibodies. These compounds also decreased the activation and number of astrocytes. CONCLUSION:This study concludes that bioactive compounds confer protection in rat model of Parkinson disease. They ameliorated the degeneration of the dopaminergic neurons, accumulation of α-synuclein and ubiquitin in the cytoplasm of neurons and activation & morphological alteration of astrocytes.