۲۰ مئی ۱۹۷۹ء کوعلاج کےلئے امریکہ گئے اور۲۲ ستمبر ۱۹۷۹ء کو بفیلو ہسپتال میں آپ کاانتقال ہوا ۔
Issuing Fatwa is much important in the field of Islamic Theology. At least one of the contemporary famous three methodologies in the field of Fatwa for the mufti to adopt is necessary; as it leads mufti to extract ruling from the text of Holy Qur᾽ān or Sunnah of the Holy Prophet (ﷺ) and from what the Muslim Jurists have agreed upon. A thorough study of the book Fatāwā Ahl Ḥadīth has been conducted in this study in order to highlight the characteristics and main features which distinguish the method of the author, ‘Abdullāh Muḥaddith Rōpaṟi, a prominent scholar of his time in the main stream of Ahl e Ḥadīth, from other scholars of his time in issuing fatwa. The study approves that the author has adopted the depth has and (صلى الله عليه وسلم) Prophet Holy the of companions the of method understanding of the primary sources i. E. Holy Book Qur᾽ān, Sunnah and Ijmā‘, and secondary sources i. E. Qiyās and custom and vice versa and he has given best solutions to the matters posed to him at his time on the basis of textual and rational evidences which ultimately influenced people and made them to accept the author as an authority in his field.. His prominent work also tells us that he has expertise in the fields of Islamic literature, Islamic Jurisprudence, Ḥadīth and Tafsīr. Therefore, his book regarding fatwa has got admired by the scholars of the Subcontinent of all the main streams. Also in the court of Law in the country the book has been considered as a referencing book.
This research work consists of the synthesis of Schiff bases and sulphonamides derivatives of nicotinic and isonicotinic acid hydrazide by adopting different synthetic chemical transformations and tested of their antioxidant and bioactivities. All compounds were entirely characterized by a variety of spectroscopic techniques like EI-MS and 1H-NMR. Four chapters have been included in this critique based on the broad literature and it is regarding the three series of the synthetic compounds. Everyone has its own references, compounds tables, figures, schemes and numbering. Chapter-1 It is consisting of broad literature review related to the common introduction of Schiff bases and nicotinic acid and its reaction, various synthetic protocols and biological background. It has been also studied the several biological activities which are done on compounds. This chapter describes the synthesis of Schiff bases of nicotinic acid hydrazides 131-163 and studies of their antioxidant, antileishmanial, urease, α-glucosidase, anti glycations, α-chymotrypsin, acetylcholinetorase, butyrylcholinesterase, tyrosinase, xanthine oxidase, anticancer and antimicrobial activities. Chapter-2 Describes the synthesis of Schiff base derivatives of isonicotinic acid hydrazides 40-69 and studies of their antioxidant, antileishmanial, antiglycation, urease, α-glucosidase, α-chymotrypsin, tyrosinase, xanthine oxidase, anticancer and antimicrobial activities. Chapter-3 Describes the syntheses of sulfonamide derivatives of nicotinic and isonicotinic acid hydrazides 77-99 and their urease inhibitory activity, antioxidant, antiglycation, immunomodulatory and antimicrobial activities. In chapter-4, we describe bioassay protocol used for the all compounds.