Peran Guru PPKn Dalam Menumbuhkan Kesadaran Diri Siswa Terhadap Tata Tertib Sekolah

Penelitian ini bertujuan untuk mengetahui peran guru PPKn dalam menumbuhkan kesadaran diri siswa terhadap tata tertib sekolah di SMP Negeri 7 Gunungsitoli. Penelitian ini menggunakan metode kualitatif dengan pendekatan deskriptif. Lokasi dalam penelitian ini adalah di SMP Negeri 7 Gunungsitoli dengan informan Kepala Sekolah, Guru PPKn dan siswa. Teknik pengumpulan data yang digunakan peneliti adalah teknik observasi, wawancara dan dokumentasi. Teknik analisis data dalam penelitian ini adalah pengumpulan data, reduksi data, penyajian data dan verifikasi data. Dari hasil penelitian ditemukan adanya peran guru PPKn dalam menumbuhkan kesadaran diri siswa terhadap tata tertib sekolah antara lain (1) Guru sebagai korektor yang menilai semua sikap dan perbuatan siswa, (2) Guru sebagai motivator yang memotivasi siswa untuk dapat menaati tata tertib sekolah, dan (3) Guru sebagai pembimbing yang membimbing siswa menjadi manusia yang taat pada aturan sekolah. Selanjutnya kendala yang dihadapi guru PPKn dalam menumbuhkan kesadaran diri siswa terhadap tata tertib sekolah yaitu sifat dan karakteristik siswa yang berbeda-beda yang terkadang mengabaikan arahan dan bimbingan yang disampaikan oleh guru. Adapun upaya guru PPKn untuk mengatasi kendala tersebut yaitu terus mengingatkan siswa tentang tata tertib, menjadi contoh teladan bagi siswa dan melakukan pendekatan kepada siswa yang melanggar tata tertib sekolah.

Elucidating the Genetic Basis of Neurological Disorders in Pakistani Population

Human brain development is a complex process involving many cellular pathways. Pathogenic mutations in genes controlling as a whole or in parts, any of these cellular processes result in neurological disorders. It is basically due to defective signaling function in central or peripheral nervous system. The clinical features of such disorders are extremely diverse and overlapping, with even greater genetic heterogeneity. They may either be simple, having Mendelian inheritance or they may be complex. Genetic factors play very important role both in simple and complex neurological diseases. The consequences of such diseases are usually devastating both for affected individuals, their families and society, mainly by affecting the qualities which make human special as person; the character, memory, cognition, communication and skilled movements. In the present study, 11 consanguineous Pakistani families having neurological disorders of Mendelian inheritance were investigated using next generation sequencing (NGS) technologies. Rare and disease causing variants mostly occur in coding part of genome. Whole exome sequencing (WES) was used as a method of choice in the current study because of the heterogeneous nature of neurological disorders both clinically and genetically. Variants obtained from WES were prioritized based on their inheritance pattern, disease association, functional relevance and pathogenicity score as predicted by different bioinformatics tools such as Mutation Taster and PolyPhen-2. Segregation of all the variants were confirmed using Sanger sequencing. Ten novel and one already reported mutation were identified in this study. At present there are no effective treatment strategies available for most of these diseases. Therefore, identification of gene/s and pathogenic variant/s in these diseases will help understand underlying molecular mechanisms better, and lead to improved strategies both for genetic counseling and potential therapeutics