محمد یوسف صدیقی
افسوس ہے اِنھیں دنوں ہمارے فاضل اورلائق دوست جناب یوسف صاحب صدیقی بھی ہم سے جدا ہوگئے، مرحوم انگریزی اخبار ریڈینس (اب ممنوع) کے اڈیٹر تھے۔ علی گڑھ یونیورسٹی کے گریجویٹ تھے،انگریزی اوراردو دونوں میں تحریر وتقریر کی قدرت تھی۔بڑے ہوش و گوش اور سمجھ بوجھ کے انسان تھے۔ صبرو استقلال اورخلوص اُن کا شعار تھا، مجلسِ مشاورت کے جنرل سکریٹری تھے،جماعت ِ اسلامی (اب ممنوع) کے ہائی کمانڈ میں شامل ہونے کے باعث متعدد بار قیدو بند کی تکالیف سے دوچار ہوئے ،لیکن پائے استقامت میں کبھی جنبش نہیں ہوئی،جووقت پڑا اسے ہنسی خوشی انگیزکرلیا۔ریڈینس کے ایڈیٹر کی حیثیت سے عرب ملکوں اورخصوصاً سعودیہ عرب میں اُن کا بڑا وقار و اعتبارتھا چنانچہ وہاں کی متعدد کانفرنسوں میں مدعو کی حیثیت سے شریک ہوئے۔ گھر کے بہت خوش حال اورصاحبِ املاک وجائداد تھے۔ عمر اسّی کے لگ بھگ ہوگی، اس کے باوجود گھر کا عیش وآرام چھوڑ کرجماعتی کاز کی خاطر دلّی میں غربت اور بے آرامی کی زندگی بسرکرتے رہے۔ اپنے وطن ٹونک میں تھے کہ وہاں سے بیوی کے ڈاکٹری معائنہ کی غرض سے جے پور آئے، ابھی ڈاکٹری معائنہ مکمل نہیں ہوا تھا کہ خود انہیں پیغامِ اجل آپہنچا۔ بڑی خوبیوں کے نہایت شریف اور باوضع انسان تھے۔ اللٰھُمَّ اغْفِرْلَہٗ وَارحمہ۔ [مئی۱۹۷۶ء]
The research examines socio-cultural stereo-typed beliefs and customs of Pakistani society regarding women’s conjugal rights and reproductive health. Islamic teachings recognize and ensure both categories of women rights; general and specific. Islam has acknowledged man and woman as equal and equivalent partners of the family system. There mutual cooperation lays the foundation of a peaceful, prosperous and healthy society. According to Islamic injunctions, the socio-economic environment of the society must ensure mutual trust, matrimonial harmony, and respect of rights for both men and women. The social norms need consistent evolution to be conducive to a happy life of individuals. It goes without saying that population growth must go hand in hand with papulation planning while prosperity is directly proportional to proper management of both human and economic resources. The present article analyzes the social stereo-types about women, their conjugal rights, family planning and care for women’s reproductive health, in the light of guidance provided by Qur’an and Sunnah. Islam.
Classically Salmonella enterica serovar Typhi (S. Typhi) is associated with typhoid, a major health problem in developing countries. However, in recent years Salmonella enterica serovar Paratyphi A (S. Paratyphi A) and Vi negative variants of S. Typhi have emerged rapidly. For development of multiple protein-polysaccharide conjugates with potential to be used as vaccines, we needed to have a first hand knowledge of local distribution of these pathogens. For this purpose, we developed a nested multiplex PCR targeting 5 different genes for differential diagnosis of typhoidal pathogens which has been optimized to be directly applicable on clinical blood samples. Out of 42 multiplex PCR positive blood samples, 26, 9, and 2 were Vi-positive S. Typhi, Vi-negative S. Typhi and S. Paratyphi A, respectively and 5 patients were found to have mixed infection. Seventeen patients grew Salmonella from blood culture and the remaining 25 were positive in the Salmonella specific PCR. Tests with several common pathogens confirmed the specificity of the assay. We conclude that the proposed multiplex PCR is rapid, sensitive and specific for the diagnosis of typhoidal pathogens directly from blood samples. Detection of Vi negative strains of S. Typhi and S. Paratyphi A among typhoidal patients suggested the need to work on vaccines which are not based on Vi polysaccharide only. Therefore, O-specific polysaccharides (OSP) purified from lipopolysaccharides (LPS) of S. Typhi and S. Paratyphi A were conjugated with diphtheria toxoid (DT) using adipic acid dihydrazide (ADH) as linker, and evaluated for immunogenicity in mice. Use of DT as carrier protein for Salmonellae has not been reported before. S. Typhi OSP-AH-DT conjugate 1 and 2 elicited significantly higher IgG anti-LPS ELISA titer (P = 0.0241 and 0.0245 respectively) than polysaccharide alone. The injection schedule-B (three injections with 4-weeks interval) was found better than schedule-A (three injections with 2-weeks interval). The conjugate of S. Paratyphi A OSP with DT without linker molecule did not elicit sufficient immune response to be used as conjugate vaccine candidate while antibody response against S. Paratyphi A OSP-A H-DT c onjugate was found significantly higher (P = 0.0446) than polysaccharide alone.