ROLE OF KINESIOPHOBIA ON PAIN, DISABILITY AND QUALITY OF LIFE IN PATIENTS WITH CHRONIC LOW BACK PAIN: A SYSTEMATIC REVIEW

Background and Aim: The majority of people suffered with low back pain (LBP) at least once during their lifetime. As such, LBP is a highly prevalent and costly condition. People respond inappropriately as a result of current or possible risks and establish defensive habits (for example, hyper-vigilance) that aim at avoiding new injuries. A continued reconciling of studies which provide various answers for the same issue will be necessary for treatment decisions. This study is performed to conclude the function of Kinesiophobia and check it on   Pain, Disability and Quality of Life in Patients that are suffering from Chronic Low Back Pain: A Systematic Review. Methodology: A Systematic Review has been conducted. Secondary data collected from Electronic database including PubMed, Medline and Cochrain Library from inception to 2010. Total 554 Article found out of which 10 articles included in the study after excluding the duplicate article, Quality screening through Pedro Scale, and article don’t fulfilling the inclusion criteria of the study. Review completed within 9 months after approval of synopsis. Results: According to this Review total Sample size was 554 with mean Sample size 130±90, mean Age 46±5 years, Mean of Pain Intensity (VAS 0-10) 6.12±1.5, mean Pain Duration 30±14, mean Kinesiophobia Measures (Tampa Scale of Kinesiophobia 0-68) 37±6.5, mean Disability (Oswestry Disability Index 0-100%) 56±27, mean Quality of Life (SF 36 0-100) 39.17±15.197.  Conclusion: TSK scores showed a statistically significant correlation with Pain, Disability, education level, and SF-36 QOL. As the education level decreases, kinesiophobia scores increase and as kinesiophobia scores increase, Level of disability increases and the quality of life decreases. Patients with kinesiophobia presented greater pain intensity, a greater fear of movement and of performing physical activities and it was also associated with worse quality of life.

Analysis of Nacl Tolerance in Calli and Regerants of Unadapted and Licl Adapted Lines of Rice Oryza Sativa L.

In this study the response of calli lines of Oryza sativa L. cv.Swat-1 adapted to ion specific stress (25mM LiCl) was investigated to elucidate the underlying mechanisms of adaptations at the cellular level and their stability at regenerant stage. The physiological and biochemical parameters revealed that adaptation caused a decrease in proline, Na+, Na+/K+ratio, protein content and regeneration capability, while K+,Ca++and Mg++concentration enhanced. Exposure of cell lines to interactive effect of NaCl and CaCl2 showed that high calcium reduced the Na+ toxic effect on relative growth rates of both the cell lines with a concomitant increase in K+, Ca++ and Mg++ content respectively. While total sugar and proline contents of unadapted line increased and of adapted line decreased. Adaptation caused the appearance of one new protein band of about 67 kDa which remained stable under 200mM NaCl stress. While this band slightly appeared in unadapted line with degradation of other low molecular weight protein e.g. 17, 19 and 20 kDa. High calcium chloride caused upregulation of 67 kDa band with restoration of the damaged proteins except 17 kDa band. Regenerants and plantlets of adapted line showed excessive accumulation of osmolytes (sugar, proline) compared to accumulation in unadapted line. On the other hand the proteins’ banding pattern of regenerants was found to be similar to their respective lines. Interestingly 67 kDa band disappeared from the shoot of regenerated plantlets but was present in roots. No polymorphism was detected when 17 SSR markers related to Saltol region , 6 SSR markers for Na+/K+ ratios and one each for Na+/H+ antiport K+/Na+ symporter activity at plasma membrane was used. Transcriptional and translational inhibitors studies showed that changes due to adaptation were at translational/software level. This study reveals that the adaptation to ionic stress and supplemental CaCl2 under NaCl stress works on a similar principal of cellular homeostasis regain and adaptation at the cellular level is transferable (stable) to complete plant level.