أوهام الإمام البزار فى الأسانيد والرجال من خلال مسنده البحر الزخار

Indeed، the Sunnah of the Prophet (peace be upon him) is the second sources of Islamic Shariah. It is the sacred knowledge after the Holy Qur’an. It consists of sayings، actions and approvals of the Prophet (peace be upon him). The science of Jarh wa al-Ta’deel (narrator criticism and evaluation) is an important science for the protection of Sunnah. This science comprehensively draws differences of Saḥīḥ from Dha’īf. The religious scholars have started working on Jarh wa al-Ta’deel from the time of companions and successors. Among them a great Moḥaddis was Imām Abu Bakr  Ahmad bin ‘Amr Baẓẓār. He has written the book، “Al-Musnad Al-Bahar Al-Ẓakhkhār”. This book consists of a huge compilation of Aḥadīth and its science. Imām Bazzār has discussed about Asānīd، Ahwāl Rijāl، Ilal Aḥadīth، Mutābi’āt and Tafarradāt. He had adopted a unique research methodology، however، he was among lenient Imāms of Jarh wa al-Ta’deel. Sometimes، he misunderstood reporters and reports. This article attempts to analyze his methodology as a lenient Imām while discussing chains of reporters and reporters of Aḥadīth. This study uses a critical and comparative research methodology to investigate reporters and reports and will be beneficial for researchers and scholars in the field of Hadith and its Sciences.

Structural and Functional Studies on Proteins and Peptides of Cuminum Cyminum and Other Species

Ajwain (Trachyspermum ammi) belongs to the family Umbelliferae, is commonly used in traditional, and folk medicine due to its carminative, stimulant, antiseptic, diuretic, antihypertensive, and hepatoprotective activities. Non-specific lipid transfer proteins (nsLTPs) reported from various plants are known to be involved in transferring lipids between membranes and in plants defense response. Here, we describe the complete primary structure of a monomeric non-specific lipid transfer protein 1 (nsLTP1), with molecular weight of 9.66 kDa, from ajwain seeds. The nsLTP1 has been purified by combination of chromatographic techniques, and further characterized by mass spectrometry, and Edman degradation. The ajwain nsLTP1 comprises of 91 amino acids, with eight conserved cysteine residues. The amino acid sequence based predicted 3D structure is composed of four α-helices stabilized by four disulfide bonds, and a C-terminal tail. The predicted model was verified by using different computational tools; i.e. ERRAT, verify 3D web server, and PROCHECK. The docking of ajwain nsLTP1 with ligands; myristic acid (MYR), and oleic acid (OLE) was performed, and MD (Molecular Dynamics) simulation was used to validate the docking results. The findings suggested that amino acids; Leu11, Leu12, Ala55, Ala 56, Val15, Tyr59, and Leu62 are pivotal for the binding of lipid molecules with ajwain nsLTP1.