مولانا سید اخلاق حسین دہلوی
افسوس گزشتہ ماہ مولانا سید اخلاق حسین دہلوی کی رحلت سے علم و ادب اور دلی کی تہذیب و شرافت کا ایک روشن نقش بھی مٹ گیا۔
وہ ۱۹۰۶ء میں دہلی کے ایک معزز سادات عالیات کے خاندان میں پیدا ہوئے، ان کے پردادا سید علی بغدادی محمد شاہ کے زمانہ میں بغداد سے دہلی تشریف لائے، ان کے پوتے اور مرحوم کے والد ماجد محمد ابراہیم حسین کا شمار دلی کے نامور شرفاء میں ہوتا تھا، سید احمد دہلوی صاحب فرہنگ آصفیہ ان کے رشتہ کے چچا تھے اور مولانا دہلوی کے بھائی حکیم سید حسین دہلوی کے متعلق کہا جاتا ہے کہ دلی کی تہذیب و معاشرت کے شاید آخری کامل نمونہ تھے۔ ان کا انتقال کچھ عرصہ قبل ہوا۔ پہلے عرب سرائے، دلی کے شرفاء کی قابل احترام ہستی تھی، گردشِ روزگار سے جب یہ اپنے مکینوں سے خالی ہوئی تو اس کے آثار و باقیات کو سخت حالات کے باوجود ان دونوں بھائیوں نے قائم رکھنے کی سعی کی اور اس کے قبرستان و مساجد کی تولیت ان ہی کے ہاتھوں میں رہی۔
خاندان کے علمی ماحول کے اثر سے سولہ برس کی عمر ہی میں مولانا اخلاق دہلوی کے قلم سے ایک کتاب نکلی۔ کچھ عرصہ تک انہوں نے میرٹھ کے قصبہ بڑوت کے ایک کالج میں تدریسی فرائض بھی انجام دیے، اسی زمانے میں انھوں نے درسیات کا سلسلہ شروع کیا جیسے مضمون نگاری، میزان سخن، خلاصہ مصباح القوا عداد رشمیم بلاغت وغیرہ۔ اردو کالج دہلی کے طالب علموں کی سہولت کے لیے مولانا امام بخش صہبائی کی کتاب حدائق البلاغت کی تلخیص روح بلاغت کے نام سے کی، یہ سب کتابیں مقبول ہوئیں اور طلبہ کے علاوہ عام اردو خواں طبقہ کو بھی اس سے فائدہ پہنچا، مولانا کی علمی و تحقیقی کاوشوں کا موضوع...
Spirituality is usually understood as a way of being that flows from a certain profound experience of reality, which is known as ‘mystical’, ‘religious’, or ‘spiritual’ experience. There are numerous descriptions of this experience in the literature of the world’s religions, which tend to agree that it is a direct, non-intellectual experience of reality with some fundamental characteristics that are independent of cultural and historical contexts. Spiritual and scientific quests are two complementary inquiries into reality. Any feeling of antagonism between them is a product of a narrow vision. Science deals with what is measurable; religion is the quest for discovering and understanding the immeasurable. A scientist is not intelligent if he denies the existence of the immeasurable. There is nothing that is anti-science but there is a lot that is beyond science. The two quests have to go hand in hand. We not only need to have an understanding of the laws that govern the phenomena occurring in the external world around us but also we need to discover order and harmony in our consciousness. Human understanding is incomplete unless it covers both aspects of reality: matter as well as consciousness. Indeed the division between the scientific and spiritual quests is itself the creation of the human mind. Reality is one undivided whole which includes both matter and consciousness. Our thoughts, being limited by our experience, divide the external world from the inner world of our consciousness, in much the same way as our mind divides time from space though they are both two aspects of a single continuum۔
Thermal pressure alters the normal body homeostasis and cause rigorous injurious sound effects
on production of cattles. Dairy cattles are extra responsive to high temperature as they spawn
further energy expanded rate and this matter grasp particular consideration when the entire
picture of inclusive warm up is measured around the globe. Heat fright proteins are ever-present,
highly conserved proteins that cooperate a significant task in cell endurance through unusual
stresses. The present study was undertaken to assess peculiar relevance of HSP70 gene with heat
tolerance ability in Red Sindhi (Bos indicus), tropically evolved breed of Pakistan. The
aspiration of this study was to explore and portray the heat shock proteins gene diversity in
coding region of Red Sindhi cattle to understand their thermotolerance under hot conditions
using Polymerase Chain Reaction (PCR). The complete coding region of HSP70 is 1926bp long
without any intron, programming a protein of 641 amino acids located on chromosome No.23,
with predicted molecular weight (Mw) of 70,190.56 kDa. The functional parts of HSP70 protein
consist of an amino-terminal or N-terminal 44kDa ATPase domain (amino acid residues 1-386),
18kDa domain is peptide binding (a.a 384-543) and highly conserved 10kDa Carboxyl or
C-terminal domain (residues 542-640) in all eukaryotes. The phylogenetic examination of
mammalian HSP70 gene indicated that Red sindhi has showed (99.79 to 99.48%) homology
with Bos taurus, Bubalus bubalus and Capra hircus while least similar relationship was
observed with Canis lupus that was 86.34%. The results express that nucleotide as well as
deduced amino acid order was greatly preserved. Comparative sequence analysis of Red sindhi
HSP70 gene revealed a total of 14 single nucleotide polymorphic sites, of these 5 were
non-synonymous (C14T, G970T, C1469T, A1535T, G1560T) caused change in amino acid
sequence while 9 were synonymous. In non-synonymous SNPs the 1
one was reported and four
novel type. These 9 mutations caused no change in amino acid. 8 out of 14 were transition type
in which purines were replaced by just purines and pyrimidines replaced by other pyrimidines. 6
types were transversion mutations in which purines replaced by pyrimidines and vice versa. At
protein level, Red sindhi HSP70 gene has showed total 5 amino acid changes and two of five are
in N-terminal domain (M5T, A324S), remaining are in peptide binding domain (A490V,K512M,
Q520H). Probably damaging functional impact of amino acid change is seen in two of expressed
SNPs. These transformations can be worn as molecular genetics pointer to aid assortment for
anti-heat stress cattles. The findings of this study revealed that detected polymorphisms may be
associated with ability of bovine to adapt with tropical and harsh climatic conditions but
additional exploitation still required to draw the ending about molecular roots of thermotolerant
cattles.