ہم مدینے کی گلیوں میں جب جائیں گے
اشک اپنے تو تھمنے نہیں پائیں گے
ابرِ رحمت کے چھینٹے برس جائیں گے
اشک آنکھوں میں ہم جب بھی چھلکائیں گے
ہاتھ خالی تو واں سے نہیں آئیں گے
اک شفاعت کی سوغات تو لائیں گے
صبح ہو ، شام ہو، رات ہو یا کہ دن
اُن کی توصیف کے گیت ہم گائیں گے
زندگی کی کڑی دُھوپ میں خود کو ہم
گنبدِ سبز کے سائے میں پائیں گے
جب مدینے سے رُخصت کی ہو گی گھڑی
غمزدہ دل کو ہم کیسے بہلائیں گے
Different religious, political and social leaders tried their best to establish peace and prosperity in the society in different phases of the human history. An influential effort out of these efforts is that of the Prophet (r) Muḥammad. The Prophet (r) faced a pluralistic society of different faiths and religions in Madīnah. So, to make a better relationship and establish peace between the Muslims and the other communities of Madīnah, an agreement, which is called Mīthāq al-Madīnah, was made. Mīthāq al-Madīnah was not only a deed, but it presents all those principles and regulations, which were mandatory for peace building in a state or society. The excellent aspect of this charter is that the recipients of this charter were not the Muslims only, but a pluralistic society of different faiths. These communities were bound to establish peace with an agreement. This charter is an excellent model of peace, prosperity, freedom and human rights. According to this charter, all the parties were free with their religious beliefs and social interests. It was also the constitution of Madīnah. The renowned Muslim scholars are unanimously agreed that it was the first written constitution of the world. This agreement provides all other communities of Madīnah (the Jews, the Christians, and the polytheists) equal rights and freedom. Consequently, the charter of Madīnah can become a base for enduring peace and peaceful coexistence in a pluralistic world for the sake of the welfare of the human beings.
The indigenous plant Bergenia ciliata was investigated for bioactive constituents in this research. Five known bioactive compounds were isolated from ethyl acetate extract of this plant. The isolated compounds were identified by melting point, UV, IR, 1H-NMR and 13C-NMR as Afzelechin (173), Asarone (174), Terpinen-4-ol (175), Parasorbic acid (176)and Damascenone (177). Antimicrobial activity of isolated compounds was studied. All the isolated constituents showed antimicrobial efficiency varyingly on the selected microbes that comprised of two Gram positive and four Gram negative bacterial strains, causes infections in human. Afzelechin (173) exhibited the highest antimicrobial activity compared to other compounds. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the constituents which were explored for the first time. Afzelechin (173) showed the highest antifungal activity while Damascenone (177) has moderate activity. The second part of the thesis is comprised of Synthesis of Schiff bases and their complexation with different metals like Cu (II), Co (II), Ni (II) and Zn (II). Both the bases and their complexes were studied on the basis of their physical characterization like micro-analytical data, 1HNMR, FTIR and UV spectrum data. Schiff bases coordination with metal through nitrogen of imine and atom of oxygen was confirmed through spectrum data. Furthermore, the ligand and the metal complexes were screened against Gram positive and Gram negative bacteria for their antibacterial activity. The results showed that these complexes possess enhanced biological activity as compared to ligand bases.