مولانا محمد الحسنی
ایک عربی شاعر نے کہا ہے:
من لم یمت عبطۃً یمت ھرما
1للموت کاساًفالمرء ذائقاً
¹’’جولوگ جوانی میں نہیں مرتے وہ بوڑھے ہوکرمریں گے۔بہرحال موت کی شراب ہرشخص کے لیے چشیدنی ہے۔‘‘
افسوس ہے گذشتہ مہینہ ہمارے علوم دینیہ و عربیہ کے دومرکزوں میں چند روز کے فرق سے شعر میں مذکوردونوں قسم کی حسرتناک موتیں واقع ہوئیں، پہلا واقعہ دارالعلوم ندوۃ العلماء لکھنؤ میں مولوی محمدالحسنی کی اچانک وفات کاپیش آیا۔ مرحوم صحیح معنی میں متنبی کے اس شعر کے مصداق تھے:
وشیخ فی الشباب ولیس شیخاً
-یسمی کل من بلغ المشیبا
وہ کہنے کومولانا سید ابوالحسن علی میاں کے بھتیجے تھے مگردرحقیقت وہ مولانا کے لیے فرزند حقیقی سے بڑھ کرتھے۔مولانا نے اپنے فیض تعلیم وتربیت اورتوجہ خصوصی سے اس جوہر قابل کوایسا چمکایا کہ مرحوم عربی ادب وانشا میں مولانا کے مثنی بن گئے۔عرصہ سے’’البعث الاسلامی‘‘کے رئیس التحریر تھے، اس حیثیت سے انھوں نے جومقالات اوراداریے لکھے انہوں نے ہندوبیرونِ ہند کے اسلامی حلقوں میں دھوم مچادی۔ ان کی کتاب’’الاسلام الممتحن‘‘جوعالم اسلام اور خصوصاً عرب ممالک کے معاملات ومسائل سے متعلق اُن کے بیس برس کے اداریوں اورمقالات کامنتخب مجموعہ ہے، وہ عرب میں اس درجہ مقبول ہوئی کہ چندبرسوں میں اس کے متعدد ایڈیشن چھپ چکے ہیں۔ وہ اردو زبان کے بھی ادیب تھے۔مصنف اورمترجم کی حیثیت سے اس زبان میں بھی ان کی متعدد یادگاریں ہیں۔عمل وکردار اوراخلاق وعادات کے اعتبارسے وہ اپنے خانوادۂ والاتبار کی روایات کامکمل نمونہ تھے۔یعنی نہایت دیندار، صالح، متواضع، فقیر منش، طبیعت کے نہایت غیور و خوددار، خاموش اور باہمہ و بے ہمہ، دنیا اور اس کے زفارف عیش و عشرت سے قطعاً بے نیاز و روگرداں، عمر چالیس کے لگ بھگ ہوگی۔
خوش درخشید و بے شعلۂ مستعجل بود ۔
رحمہ اﷲ رحمۃ واسعۃ
[ جولائی۱۹۷۹ء]
Allah Almighty, with his power, created the sky, earth and whole universe and provided all the necessities. Therefore, the work of preaching Islam is conferred upon the Ummah of Holy Prophet (P.B.U.H). There are the people who had been taught the teachings of Islam directly by Holy Prophet and they preached Islam in the same way as they were taught. They practiced all the teachings in their lives. Sahaba R.A, for preaching Islam, went to the east, west, north, south, Hind, Sindh and the corners of the world. As a result of their efforts, almost half of the world got the message of Islam. Tabaeen consisted of many people, in the light of Quran and Sunnah, conveyed the message of Islam throughout the world. In the same way, another group of people named Tab Tabaeen became prepared to spread the universal message of Islam. They didn't ignore any sacrifice to uplift the spirit of Islam. With their struggle, many great people like saints, jurist, reader and interpreter of Quran and Hadith born. These people tried their best to convey the message of Islam through written and spoken discourse. Religious books and places were introduced. That process of education, after many years, is still continuing. Presently, many religious places are constructed to preach spiritual guidance in which many great scholars and saints are engaged. History is witness that opponents went to extent possible level to aloof Muslims from teaching, preaching and guiding of lslam. Not only were this but the Muslims intended to end also. In these trials and tribulations, saints took responsibility on their shoulders and continued their struggle on the directed path of oneness, Prophet hood, Ahle Bait and Sahabas against the evil forces. Among such great Family of Pir Pagara is one whose line is continuing in Hind and Sindh. Insha Allah (If God wills) it'll continue till the last day. There is his great religious and social contribution. To convey, his valiant services towards people, research on this personality is dire need of the hour. In history, this research will be advantageous for the researchers to come.
The sunshine vitamin is in the limelight for the last couple of years. Though Pakistan is located at favorable latitude and longitude yet vast majority of its people suffer from vitamin D deficiency. Calcium homeostasis, bone metabolism and many other functions of body are influenced by vitamin D. Nuclear vitamin D receptor and group specific vitamin D binding proteins are two important proteins play role in vitamin D metabolism and encoded by VDR and GC genes. There could be many reasons but in this study six single nucleotide polymorphisms in GC, VDR and CYP2R1 genes were looked into for their possible association with vitamin D deficiency. Blood samples of four hundred subjects were collected. Vitamin D and parathyroid harmone levels were calculated by chemiluminescence method. DNA extraction was carried out by phenolchloroform method. The qualitative and quantitative analysis of DNA was carried out on agarose gel electrophoresis. Tetra amplification refractory mutation system polymerase chain reaction was performed to genotype rs7041, rs4588, rs2060793, rs2282679, rs3847987, and rs7974353. Genotypic and allelic frequencies with relative risk was calculated. In Silico protein modelling, docking and analysis of rs7041 was done. Overall 77.5% subjects were found to be with vitamin D deficiency/insufficiency. There were 35% from newborn to 20 years age group, 88.8% from 21-40 years and 95.8% from to 41-60 years.Significant negative correlation was observed between vitamin D and parathyroid hormone levels. rs 7041 belonging to GC genes showed T>G polymorphism. Major allele was T and minor allele was G. Minor allele “G” with genotype GG could be a risk allele contributing in vitamin D deficiency. rs7974353 belonging to VDR gene showed T>A polymorphism. Though “TT’ was in high frequency in VDD subjects compared to control yet insignificant association with VDD was noted. RR for both alleles and genotypes TA and AA was not significant with reference to homozygous wild type TT (0.6 for AT, 0.7 for AA). Results might had been xxi sigificant if thenumber of subjects were more. Rest of the four SNPs showed equal frequency in control and cases and hence showed no association with vitamin D deficiency. In silico model of SNP rs 7041 showed variation in the 3D structure of protein because of replacement of asparctic acid by glutamic acid. This can explain the cause of VDD / VDI due to poor docking of vitamin D with its binding protein. Conclusion is that rs7041 and possibly rs7974353 are contributing to VDD / VDI in studied group. Results are supported by In silico analysis of rs 7041.