53. An-Najm/The Star
I/We begin by the Blessed Name of Allah
The Immensely Merciful to all, The Infinitely Compassionate to everyone.
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a. By the star when it sets.
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a. Your companion who has lived amongst you for forty years is neither strayed nor is he deluded,
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a. nor does he speak out of his own personal desire with regard to what he recites to you of The Qur’an,
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a. that which he conveys to you - The Qur’an - it is nothing but a Divine Revelation, being
revealed on to him.
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a. Taught to him by the One of Awesome in Power,
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a. Full of wisdom.
b. HE stood poised,
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a. while HE was on the highest part of the horizon.
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a. Then HE drew near and came close,
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a. so much so that it was left only a space of the strings of two bows – facing each other, surrounding him in all directions - or even closer than that.
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a. So HE revealed on to HIS Servant Muhammad whatever HE revealed.
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a. The Prophet’s heart did not lie about what it saw.
b. He neither perceived it as an illusion nor was it a hallucination.
c. It was a reality.
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a. Are you, then, going to argue with him what he saw?
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a. And, certainly, he saw HIM yet again at another time, too,
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a. by the Lote Tree of the Extremity,
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a. close to which is the...
تعمیرِسماج کا اسلامی منہج : حضرت عمر فاروقؓ کی فکر و بصیرت کی روشنی میں تجزیاتی مطالعہ The modern era is considered as advanced and humanized in terms of materialized advancement only. Today the leading societies of the world have created a self-sufficient religion in the name of humanism and have set standards ignoring Divine guidance. Thus, man has the right to decide the rules and norms of society on his own goodwill. As a result, the breaking of family system, appearance of gay and homosexual relations, etc. Are being considered as legitimate in many countries where religion is no more considered a guiding principle. On the other hand, revealed religions have focus on the development of humanity in terms of both the ethical and materialistic perspectives. Islam as religion has provided a model of such an advancement and social change in history that has proven that Divine guidance is major source for betterment and development of civilization and humanity. This was practically proven in the time of Muslim golden rule in the world. The caliph Umar (R.A) was the man who introduced for the first time, the principles and values, which has changed the Arabs to a civilized and humanized nation. This huge change was made possible in the light of Divine guidance. In this academic article all such norms, values, and principles that were introduced by Sayyīdnā Umar (R.A) which brought a social change in his Era are discussed. Facts have been collected from historic books and presented following the descriptive and analytical method. Although, the information was narrated and scattered in the books, no proper study was introduced where the role of these reforms in the social construction was analyzed. The aim of the study has to investigate the historic facts of social change in the era of the righteous Caliph Sayyidna Umar bin Khattāb and prepare a guideline for the humanity in present era.
Dengue virus (DENV) is an insect borne virus classified in the family Flaviviridae. DENV is the most widespread arthropod borne virus across the globe and according to latest epidemiological reports dengue fever (DF) is one of the major cause of concern for global health.Amongst all four DENV serotypes predominately circulating serotypes in Pakistan are DENV2 and DENV3. RNA interference (siRNA and miRNA) is at the forefront of molecular approaches for inhibitory studies. The present study was aimed at inhibition of both these serotypes via siRNA interference; moreover structural genes were cloned for insilico analysisto facilitate strategies for the development of vaccines against DENV. Both DENV2 and DENV3 were targeted by synthetic siRNAsdesigned against conserve regions in the genome. Six siRNAs were designed against both DENV2 and DENV3 from three vital regions of genome 5''untranslated region (5''UTR), 3''UTR and structural genes. Transfections were performed by Lipofectamine and level of inhibition was observed by performing several viral titer estimation assays. Results showed thatDENV3UTR3''siRNA2 targeting 3'' UTR was able to inhibit DENV3 replication.The replication cycle of DENV has revealed that in human Dendritic cells (DCs),Furin enzyme converts the immature DENV pre-membrane protein (prM) to mature M protein assisted by change in cellular pH.Therefore, in the later part of study fully mature DENV2 were allowed to infect and later targeted by RNAi. Results from this study showed that siRNA (DENV2SsiRNA2) targeting the M region of genome was able to drastically knock down DENV2 in Vero-81 cells. Substantial inhibition was also seen by siRNA (DENV2UTR3''siRNA2) targeting 3'' UTR region ofDENV2 genome. Structural genes were cloned from locally isolated DENV2 serotype. All three genes (Capsid, prM and Envelope) were subjected to insilico analysis involving construction of phylogenetic trees and prediction of epitopic domains. It was observed that both Pakistani and Indian DENV2 share a strong sequence similarity. Inhibition of both DENV serotypes via RNAi highlights the effectiveness of molecular approaches for anti-dengue drug development. Moreover, findings of insilico study of Pakistani DENV2 serotype will assist in the development of regionally targeted vaccine for densely populated South Asian region.