مزاح کے انسانی نفسیات پر اثرات اسلامی تعلیمات کی روشنی میں Effects of humor on human psychology in the light of Islamic teachings

Every branch of art leaves a deep impact on the human psyche, but the immortal fact is that the reason for their creation is also to reduce the tension of the human mind. The most representative theory of humor in philosophy and psychology and even in physics. Is the idea of ​​well-being, comfort or well-being? Broadly speaking, this suggests that humor (which has an obvious physiological effect) has effects on the nervous system and allows different levels of stress to be released. In other words, laughter and good humor have the ability to release stored nervous energy. Humor is included in human nature and man has a strong desire for this thing that there should be such means for him to express joy and expansion. Because through them, man is blessed with mental and physical peace and comfort. In these things, he considers the survival of his self-respect. Islam not only allows humor, sports and entertainment, but also sets rules and regulations within which human beings can fulfill their natural needs. Its cultural traditions should also be propagated. As the head and governor of the Islamic state, the Holy Prophet (ﷺ) made the best arrangements for his state, the taste of the people and their entertainment, and set an example for the rulers that, like other matters, oppression in this not to be taken for granted, fun and humor are part of human nature. He (ﷺ) allowed fun and laughter and He (ﷺ) himself used to be cheerful. Islam admires cheerfulness and cheerfulness, and encourages it so that people can be refreshed and perform their duties in an auspicious manner. Through this paper, it will be clarified that what are the effects of humor on human psychology and what are the teachings of Islam and the Prophet of Islam in this regard. Key Word:    Fine Arts, Humor, Human terms, Human humor

Factors Associated With Cardiac Dysfunction Following Anthracyline-Based Chemotherapy in Adults in a Tertiary Hospital in Nairobi

Introduction: Anthracyclines are known to improve survival in some malignancies, but may also be associated with irreversible cardiotoxicity, which is partly dose dependent. Early detection of cardiotoxicity provides an opportunity for treatment adjustment. Several parameters predict development of clinically manifest cardiac dysfunction. The study aimed to evaluate clinical and echocardiographic parameters which predict development of cardiac dysfunction in a sub-Saharan African population. Methods: Patients with a diagnosis of cancer and receiving anthracyclines at AKUH,N were evaluated if they met eligibility criteria (≥18years at first anthracycline administration, archived baseline echocardiogram, no prior history of heart disease or use of anthracyclines). Patients underwent echocardiographic, baseline clinical , drug therapy, radio-therapy and cardiovascular risk factor assessments. Echocardiographic global longitudinal strain (GLS), left ventricular (LV) ejection fraction and LV volumes were assessed. A relative decline from baseline in GLS of >15%, an absolute decline in LVEF >10 percentage points to <53%, or symptomatic absolute decline in LVEF of 6-10 percentage points to <53% defined LV dysfunction (cases). Factors associated with development ofLV dysfunction were compared between cases and controls (no LV dysfunction). Results: From 14-Oct-2013 to 11-Apr-2019, 504 patients who received anthracyclines were screened. 141 fullfilled inclusion criteria and were analysed (mean age, 47.7 years ± 11.2, Africans 95%, females 85.1%). Breast cancer patients were 82%, lymphoma 12%, sarcoma 5%, and leukaemia 1%. 39 (27.7%) had cardiac dysfunction, 30 of whom fulfilled the GLS criterion. Mean time interval between echocardiograms was 14.3 months (cases 16.4 ± 16.9; controls 14.4 ± 13.2), mean anthracycline dose was 244.7mg/m2 ± 72.2 (cases 254.5 ± 78.7; controls 241 ± 69.6), and mean symptom scores (DASI) were 50.0 ± 13.3 (cases 48.5 ± 13.4; controls 50.5 ± 13.2). Mean cardiotoxic doxorubicin equivalence dose was 236.7 mg/m2 ± 57.4 for cases and 217.3 ± 61.9 for controls [p = 0.033, OR = 1.00 (95% CI: 0.99 - 1.01)]. Cycle intervals, body surface area, body mass index, blood pressure, age, concomitant medication, radiation use and cardiovascular factors were similar. Echocardiographic parameters – E/a ratio and e’ were significantly reduced in cases (E/a 1.02 ± 0.33 for cases vs 1.16 ± 0.36 for controls, p =0.02: e’ 0.10 ± 0.05 for cases vs 0.11 ± 0.05 for controls, p =0.011). Conclusion: This is the first study evaluating early cardiotoxicity in an adult Sub-Saharan population receiving standard dose anthracyclines. The incidence of early cardiotoxicity was 27.7%, which was higher than in previously studied