مولانا محمد یوسف بنوری/قاری محمد یعقوب
سیمینار میں مولانا محمد یوسف صاحب بنوری کی وفات حسرت آیات کی اطلاع ملی اورواپسی میں جناب قاری محمد یعقوب صاحب(کراچی)کے حادثۂ انتقال کاعلم ہوا توسخت صدمہ اورملال ہوا۔ رحمھما اﷲ رحمۃ واسعۃً۔ اکتوبر اور نومبر میں بعض ضروری علمی کاموں میں، میں اس درجہ مصروف رہا کہ برہان کی طرف بالکل توجہ نہیں کرسکا۔یہ نظرات لکھنے کے لیے بھی بڑی مشکل سے وقت نکال سکاہوں۔ آئندہ انشاء اﷲ’’وفیات‘‘کے زیر عنوان مرحوم بزرگوں کا تذکرہ ہوگا۔ [نومبر۱۹۷۷ء]
Breast carcinoma is among the most common malignancy in women. Objective: Aim of the present study was to evaluate the prognostic significance of iron expression in the biopsies of patients with breast cancer. Methods: 24 breast biopsies were studied. 19 cases were poorly differentiated, 5 cases were moderately differentiated and there was no well differentiated case. Iron, Estrogen receptor (ER), Progesterone receptor (PR), HER2 and Ki-67 immunohistochemical staining was performed for all these cases. Results: Among the 5 moderately differentiated cases, 3 (60%) were positive for iron staining and among 19 poorly differentiated cases, 11 cases (57.89%) were positive. More iron positive cases (7 out of 14) were triple positive belonging to Luminal B class. Out of 14 iron positive cases, 11 were positive for HER2, 10 for ER, 9 for PR and all positive for Ki-67. Conclusions: Iron deficiency in premenopausal and overload in post-menopausal women can contribute to the development of breast carcinoma. So, iron can be considered as a cheap and effective marker for the prognosis of breast cancer. Association between a risein iron levels and HER2 expression may providenewstrategy for breast cancer treatment.
Some Subclasses of Analytic Functions Related with the Generalizations of Functions with Bounded Boundary Rotation Geometric Function Theory on broad spectrum mostly deals with the geometric properties of univalent, multivalent, meromorphic functions etc. and Theorists paid much of their attention to the classes of these functions. Various subclasses of analytic functions related with the Carathéodory functions along with their generalizations were studied systematically in various aspects in the literature of the subject. The main focus of this study is to define certain new subclasses of analytic functions related with the functions of bounded boundary rotation and their generalizations. We use the idea of convolution and subordination along with the concepts of bounded Mocanu variation, Robertson functions, multiplier transformations etc. in defining these classes of analytic as well as multivalent functions. We also investigate and explore these classes and study various results like coefficient bounds, radius problems, inclusion results, integral and convolution preserving properties etc. and their relationships with the previously known results.