عشق آمادہ ہیں گل دیکھ کے صورت اس کی
جی جلاتی ہے گھڑی بھر میں محبت اس کی
اس ستم گر کی نگاہوں کا سحر، اُف توبہ
جان دی جس نے، کہو خوب ہے قسمت اس کی
صبح کا نور ہو یا پھر ہو شفق کی سرخی
نور و نکہت سے بیاں کیسے ہو رنگت اس کی
وصل اور ہجر محبت کے پیمبر ہیں مگر
شب کی آغوش سے ملتی ہے طبیعت اس کی
اس کی آواز لپکتا ہوا شعلہ ہے فضاؔ
مجھ کو آواز بھی لگتی ہے قیامت اس کی
Cardiovascular diseases (CVDs) are the top most cause of morality around the world. It is predicted that the number casualties from CVDs will increase to more than 24 million till 2030 people. Medicinal plants provide the major raw materials for medicine preparations. They are gaining high consideration due to their effectiveness and increasing cost of modern medicines. Many successful drugs are plant based, including aspirin from the willow bark, morphine from opium poppy, quinine from the cinchona bark, and digoxin from the foxglove. According to World Health Organization (WTO), ~70% to 80% of people around the world rely on herbal sources for the treatment of their disease. Plant sources are endorsed due to the fact that they contain an optimal amount of antioxidants and phytochemicals that help to avoid and treat many diseases. Phoenix dactylifera L. Particularly Ajwa variety, is the most rich in phytonutrientsthat can benefit to control many cardiovascular diseases. It contains6 vitamins (vitamin A, C, B1, B2, B3 &riboflavin), high amount of fibers, Potassium, Magnesium and 23 amino acids which play a healthy role towards hypertension, muscular contractions, and blood pressure control. It has been studied that Niacin (B3) helps to control cholesterol and low density lipoprotein levels (LDL), as high cholesterol is the one of the main cause of cardiovascular diseases so, Ajwa could be a vital regulatory source. According to the findings of Sabbah M. Et al, Ajwa extracts significantly improved the DNA integrity and also reduced the cardiomyocytes congestion, edema and the cellular stress wielded on cardiac muscles resulting the restoration of cardiomyocytes architecture in Doxorubicin (DOX) induced cardiotoxicity in rats. Research done by Alqarni et al, proves that Ajwa extracts has successfully decreased the LDL‐C, VLDL‐C, and triglycerides concentration. Additionally, treatment with ajwa pulp also improved the HDL‐C level and antioxidant enzymes activity. In another invivo study, Ajwa preparation has successfullydecreased the diclofenac-induced pulmonary and hepatic instabilities. Vitamin-K play important role in blood coagulation, and in case of anticoagulant therapy, activity of vitamin-K controlled by drugs (warfarin) that sometimes causes serious side effects. According to the reported data, Salicylic acid is the vitamin-K antagonist and has capability to block the action of vitamin K during the coagulation pathway. Dates contain ~3.75 to 4.50 mg/100 g of salicylic acid. Thus, providing anticoagulation effect too. So, the limelight of the reported data provides an enough reason that plants can be used as primary source of drug designing for the cardiovascular disease. They hold true momentum to address the increasing healthdiseases, which cannot be lost to distraction or apathy. Fight against the burden of CDVs, is affecting all countries and specially, under developing and the poor countries.
Alopecia is a genetic disorder characterized by distinct forms of baldness. Main reason of alopecia is the imbalance between hair fall and regrowth. Alopecia has two broad types syndromic alopecia which occur along with other clinical conditions like epilepsy, nail dystrophy etc. Non syndromic alopecia does not show any extra clinical conditions. Androgenetic alopecia is commonly known as male pattern baldness. 80% of males above age of 70s and 80s are affected by this condition. In Asian general population approximately 73% instances of disorder has been reported. High level of circulating androgens which are actually steroid hormones are possible cause of male pattern baldness as scalp hair follicles show sensitivity for these circulating androgens. This association between androgens and male pattern baldness make androgen receptor gene as a promising candidate to check the pathogeneses of androgenetic alopecia. The rs6152 a single nucleotide polymorphism in exon 1 of AR gene has been reported in association with androgenetic alopecia. This study will check the association of mention polymorphism with AGA in random Pakistani male population.