معین احسن جذبی
۱۳؍ فروری ۲۰۰۵ء کو اردو کے معمر ادیب اور مشہور ترقی پسند شاعر جناب معین احسن جذبی نے داعی اجل کو لبیک کہا، وہ اعظم گڑھ کے مشہور صنعتی قصبہ مبارک پور کے مضافات میں ۲۱؍ اگست ۱۹۱۲ء کو پیدا ہوئے اور علی گڑھ میں جابسے، یہاں ۱۹۴۱ء میں آئے، ۱۹۴۵ء میں مسلم یونیورسٹی کے شعبہ اردو میں لکچرر ہوئے، اس سے قبل ’’آج کل‘‘ کی ادارت سے بھی منسلک رہے، ۱۹۷۴ء میں ریڈر کے منصب سے ریٹایر ہوئے۔
جذبی صاحب نے نظم و نثر میں کئی کتابیں یادگار چھوڑیں، ’’حالی کا سیاسی شعور‘‘ کے نام سے ڈاکٹریٹ کا مقالہ لکھا جو اردو کی اہم تنقیدی و تحقیقی کتاب ہے، آخر میں اپنے خود نوشت حالات لکھ رہے تھے مگر یہ کتاب نامکمل رہی، ان کے تین شعری مجموعے بھی شایع ہوئے، فروزاں، سخن مختصر اور گدازشب۔
مرحوم کا شمار صف اول کے ترقی پسند شعرا میں ہوتا ہے، وہ مخدوم، سردار جعفری اور مجاز کے ہم عصر تھے، ترقی پسند تحریک سے ان کا تعلق برابر رہا مگر ان کی شاعری اس کی عام بے اعتدالیوں سے محفوظ اور اپنی بعض الگ خصوصیات رکھتی تھی، وہ اپنی شاعری کو خوب سے خوب تر بنانے کے لیے اس میں برابر حک و اصلاح کرتے اور نقد و احتساب کی نظر ڈالتے رہتے تھے اور جب خود پوری طرح مطمئن ہوجاتے تب ہی کسی کو شعر سناتے یا منظر عام پر لاتے۔
جذبی صاحب نے ۹۳ برس کی طویل عمر پائی، مدتوں درس و تدریس کے پیشے سے وابستہ رہنے کی وجہ سے ان کے تلامذہ کی تعداد زیادہ ہے، کئی یونیورسٹیوں میں ان پر تحقیقی مقالے لکھے گئے، کئی اردو اکیڈمیوں کے علاوہ غالب ایوارڈ اور اقبال سمان بھی ان کو ملا۔
وہ بڑے انسان دوست تھے، اپنے طالب علموں اور خوردوں...
Human Rights and Rights of Miorites areattractive slogans in the global canvas. In the history of human beings many religions, their leaders, empires, and institutions claimed that they provided many human rights to the citizens of their countries, but the truth is that they failed to provide a complete code of rights to their minorities. In this regard the Treaties of the Holy Prophet Muhammad (Peace Be Upon Him) are a road line for all the Human beings, giving the fundamental rights, specially to non- MuslimMinoritess in the first Muslim state of Madinah. It has been highlighted in the Medina pact, contract with the Christian, people of Najran, letter of protection (Amman Nammah) for the people of Yamman, Maqna, Honain, Khaibar, Eilah, Ummay Hani, contract with Majoos, providing and sending them “ Letter of protection” to the people of Hajjar(Bihrin). There are many sayings in the books of Siah sittah and others giving the rights to the non-Muslim Minorities. This Paper ends by giving main principles of human right and providing some suggestions to solving the non-Muslims issues in mslim state in the light of treaties of the Holy Prophet ( Peace Be Upon Him).
The present study aimed to study the distribution of single nucleotide polymorphisms in toll-like receptor 2 (TLR2) gene in two important cattle breeds Friesian (locally adopted) and Bhagnari (indigenous) of Pakistan. TLR2 is a key receptor in the innate immune system by recognizing a variety of microbial ligands known as pathogen associated molecular patterns (PAMPs). To date, ten TLRs (TLR1 to TLR10) have been discovered in cattle. In this research work, DNA samples of the included breeds were provided by Molecular Biology and Biotechnology laboratories, Virtual University of Pakistan. The DNA samples were quantified and used for PCR amplification through six pairs of primers enclosed complete gene. The complete bovine TLR2 gene showed two exons with CDS of 2355 bp encoding 784 aa long protein with predicted molecular weight 104 kDa and 6.97 pI value. Twenty samples of each breed were amplified and sequenced for mutational analysis. A total of nineteen (19) polymorphisms were detected in the CDS of TLR2 gene in Friesian cattle. Among them six polymorphisms were non-synonymous at positions p.63E>D, p.326Q>H, p.337K>R, p.417S>N, p.563H>R, p.665Q>H and thirteen polymorphisms were synonymous. Thirteen were transition type six were transversion type mutation. One polymorphism was identified as novel and rest were reported in earliest studies. Eleven variations were observed in the ECD, two in transmembrane and five were detected in TIR domain. A total of seven polymorphisms were detected in the CDS of TLR2 in Bhagnari cattle. Five polymorphisms were non-synonymous at positions p.147Q>P, p.227L>F, p.335I>T, p.345S>N and p.605M>T and two polymorphisms were synonymous. Five polymorphisms were transition type and two were transversion type mutations. Three of them were identified as novel variations. Four polymorphisms were observed in the ECD, one in transmembrane and two were TIR domain. SNPs identified in EC domain in both breeds fell within the leucine-rich repeats (LRR) region that responsible for ligand recognition. The ratio of dS/dN substitutions was <1 at polymorphic-sites indicating purifying selection. The deduced amino acid sequence revealed a signal peptide (20 amino acids) conserved EC domain (54-584 amino acids) with 20 motifs of leucine rich repeats (LRR), transmembrane domain (585-607 amino acids) and Toll-IL receptor domain (633-783 amino acids). The 3D structure of TLR2 in both breeds is to be solenoid structure based on the positions of LRR. Phylogenetic analysis was performed revealed clustering of Bhagnari with Bos indicus and Friesian with Bos taurus as the nearest neighbor. The polymorphisms in TLR2 can be useful in future research exploring its role in immunity and may use as a marker for disease resistance by selective breeding.