اعجاز صدیقی
افسوس ہے ہمارے عزیز دوست اوربچپن کے ساتھی جناب اعجاز صدیقی کاپچھلے دنوں بمبئی میں اچانک انتقال ہوگیا۔اناﷲ واناالیہ راجعون۔
مرحوم مولانا سیماب اکبر آبادی کے فرزند ارجمند اوراُن کے خاص تربیت یافتہ تھے۔اردو کے بلندپایہ اورقادرالکلام شاعر توتھے ہی، بڑی بات یہ ہے کہ فن کے اصول وفروع اوراُس کے رموزونکات اورزبان کے قواعد اوراُس کے مصطلحات پر اُن کی نگاہ وسیع اوردقیق تھی، اس بناء پر وہ نقاد بھی بہت اچھے تھے۔نثر بھی شگفتہ لکھتے تھے۔تقسیم کے بعد آگرہ کے حالات ناقابل برداشت ہوئے اور وہاں رہنا دشوار ہوگیا توبمبئی منتقل ہوگئے۔یہاں اُن کوسخت پریشانیوں اوردشواریوں سے سابقہ پیش آیا لیکن انھوں نے بڑی ہمت اورجواں مردی سے ان سب کا مقابلہ کیا۔ ’’شاعر‘‘کو نہ صرف یہ کہ جاری رکھا، اُس کوبہتر سے بہتر بنانے کی کوششوں میں لگے رہے اورآخر کاربمبئی ایسے غدارشہر میں اپنا ایک خاص مرتبہ ومقام حاصل کرنے میں کامیاب ہوئے۔ اُن کو اردو سے عشق تھا، تقسیم کے نتیجہ میں اُس پر جو بپتا پڑی تھی، مرحوم عمر بھراُس کا ماتم کرتے اوراُس کی اصلاح کی جدوجہد کرتے رہے۔طبعاً بڑے خوش خلق،غیورو خوددار،باوضع اور نہایت محنتی اور جفاکش انسان تھے۔ اُن کی وفات سے اردو اپنی فوج کے ایک بہت بڑے مجاہد سے محروم ہوگئی۔ اﷲ تعالیٰ اُن کومغفرت وبخشش کی نعمتوں سے نوازے۔
[مارچ۱۹۷۸ء]
Background of the Study: Lockdown was implemented worldwide to limit the spread of COVID-19. This sudden implementation of lockdown causes significant lifestyle changes for every individual. Along with the general population, it also has psychological, behavioral, and physical consequences on athletes. The study objective is to determine the occurrence of lower extremity musculoskeletal injuries during the COVID-19 lockdown in athletes.
Methodology: Retrospective cross-sectional study design was used, and participants were recruited by a non-probability convenient sampling technique. A sample size of 147 was taken as calculated by the Raosoft software, and the study was completed 6 months. Both male and female athletes between the age group of 18-35 years, participants who did not participate in any official training session during the lockdown and registered at domestic level for at least 2 years were recruited from Pakistan Sports Board and Wapda Sports Complex Lahore. Data was collected using a semi-structured questionnaire. Nordic Musculoskeletal Questionnaire was used to identify the problematic painful areas of body. Data entry, analysis, and interpretation were done by using SPSS software version 22.0.
Results: The mean age and BMI of participants were 25.6531±4.49 (years) and 23.28±3.24 (kg/m2) respectively. From the total, 39.5% of participants reported lower extremity musculoskeletal injuries. And most reported problematic areas include lower back and knee. 75% of participants continue to do workouts at home as a prevention strategy against injury occurrence.
Conclusion: This concluded that the occurrence of lower extremity musculoskeletal injuries during the lockdown was moderate.
Oral squamous cell carcinoma (OSCC) is the most common malignancy in head and neck region with an occurrence rate of 500,000 per year. Higher incidence and mortality rates have been observed in south-east Asia including Pakistan. The common sub-site found in Pakistani population and other physiological variations are strongly linked with the increasing use of smokeless tobaccos (SLTs). Early diagnosis plays a key role in treatment and monitoring of any cancer. Histopathology is the only diagnostic method recommended for OSCC which is not very effective for early stage diagnosis. Thus, biomarker studies have been conducted all around the world using proteomics techniques in search of potential candidate diagnostic biomarkers. In current study, we have performed comparative proteomic analysis using buccal mucosa OSCC tissue samples and their adjacent normal mucosa. The samples were subjected to two-dimensional gel electrophoresis and differentially expressed spots were selected for Mass spectrometric analysis. We have identified seventeen proteins that were consistently differentially expressed among most of the samples analyzed. The differentially expressed proteins that have been uniquely identified in this study include Serum albumin (ALBU), Ig Kappa chain C region (IGKC), and Isoform 2 of fructose bisphosphate aldolase A (ALDOA). We suggest that further research would be required to investigate their role in carcinogenesis and whether any of these could serve as potential biomarker. The significantly altered expression of Calreticulin (CALR), Heat shock protein beta 1 (HSPB1), Heat shock protein 70 (HSC70), Cytokeratin-8 (KRT8), Cytokeratin-16 (KRT16), Cytokeratin-14 (KRT14), Cytokeratin-17 (KRT17), and 14-3-3σ/Stratifin (SFN) found in our study strongly supported the earlier reported results. We also performed immunohistochemistry (IHC) to confirm the higher expression of SFN as potential biomarker. SFN plays an important role in p53 apoptotic regulation and therefore findings of our study reveal and suggest it as a potential candidate biomarker in Pakistani population. XII Considering the association of oxidative stress with cancer progression, we also studied markers of oxidative stress in OSCC including Paraoxonase1 (PON1), Reactive oxygen species (ROS), and Malondialdehyde (MDA). We found significant relationship among oxidative stress indicators, particularly PON1 with OSCC suggesting PON1 as predictive marker.