كمال التحقيق في ترجمة نبي الله يوسف الصديق

This study sheds light on the life of an important figure that has had a great impact on humanity throughout history and that is the personality of Prophet Yūsuf Al-Siddīq “Joseph the Truthful”، peace and blessings of God be upon him. Since sources cited different narratives revolving around the events in the Prophet’s life، the researchers aimed to explore such events in the archived sources pertaining to his life. The inductive comparative method was used to conduct this thorough study of Prophet Joseph’s biography. Having defined the meaning of the name of the Prophet Yūsuf Al-Siddīq “Joseph the Truthful”، the names of the Prophet’s ancestors were traced and explored based upon a documented proof of his genealogical ancestry. The study also sheds light on the Prophet’s homeland where he was born and raised.  The study also explores the qualities of beauty that God bestowed on Prophet Joseph. Moreover، the study also discusses the Prophet’s morals، ethics and disposition. The study concludes with an investigation into the marriage of Prophet Joseph، peace be upon him.

Synthesis of Novel Derivatives of Heterocyclic Compounds Containing Fused Pyridine Ring

The present work deals with the synthesis of pyridine fused heterocyclic compounds, three condensed pyridine systems were selected for this project; Benzo[b]pyridine (Quinoline) (a), Pyrazolo[3,4-b]pyridine (b) and Pyrano[2,3-b]pyridine (c).Various strategies were utilized for introducing an ester functionality on the 4 position of (a) and (b) by utilizing Doebner-vonMiller reaction or additionally the use of Pfitzinger’s synthesis of quinolines. For (c) the ester group was introduced at the 3 position by applying a Knoevenagal condensation of ethyl acetoacetate and 2-hydoxypyridine-3- carbaldehyde. These ester groups in (a), (b) and (c) were converted to their respective carbohydrazides which were condensed with a number of arylcarbaldehydes to furnish their hydrazones. The final cyclization to the 1,3,4-oxadiazoles were effected by using various methods. POCl3 was very useful for this purpose. The products of the systems (a). (b) and (c) were thus synthesized and fully characterized by IR, 1HNMR, 13CNMR and MS and elemental (C,H andN) analyses.The results obtained confirmed the formation of the desired products. The final products were screened for their antioxidant and enzyme inhibition activities. viii Some azabicyclic compounds (I, II, III) were also prepared through ring closure metathesis by using Grubbs catalyst (Second Generation). These compounds were prepared through a multisetp strategy involving alkylation, RCM, decarboxylation, hydrolysis, Curtius reaction and finally cyclization to get the desired bicyclic compounds.These were characterized through 1HNMR, DEPT and HRMS.