ڈاکٹر عبدالستار صدیقی
افسوس ہے پچھلے ماہ ڈاکٹر عبدالستار صاحب صدیقی کاالہٰ آباد میں انتقال ہوگیا۔ مرحوم ہندوستان کے ان مغربی تعلیم یافتہ اکابراساتذہ عربی وفارسی میں سے تھے جن کی نسل اب چراغ سحری ہے۔مرحوم علی گڑھ کے اس زمانے کے پڑھے ہوئے تھے جب کہ ابھی وہ صرف کالج تھا۔انہوں نے یہاں پروفیسر یوسف ہورووتس(JOSEF HOREVITZE)جو صدر شعبۂ عربی تھے ان کی شاگردی میں عربی میں ایم۔اے کیااور جب ان کوحکومت ہند کی جانب سے اعلیٰ تعلیم کے لیے وظیفہ ملا توموصوف کے ہی مشورے سے۱۹۱۲ء میں جرمنی چلے گئے۔اس زمانے میں جہاں تک عربی اور فارسی میں ریسرچ کاتعلق ہے فرانس کے ساتھ جرمنی کے نام کابھی دنیا میں غلغلہ بلند تھا۔جرمنی میں جو مستشرقین علم و تحقیق کے جوئے شیر کے کوہکن مشہور تھے ان میں پروفیسر تھیوڈور نولڈیکی اورپروفیسر انولتمان(ENNO LITTMAN)(۱۸۷۵ء۔۱۹۵۸ء) سرخیل گروہ تھے۔ان دونوں کااورخصوصاً موخرالذکر کاخاص فن سامی لسانیات تھا۔خوش قسمتی سے مرحوم کوجرمنی میں ان اساتذہ سے استفادہ کاپورا موقع ملا۔پروفیسر انولتمان ان کے استاد خصوصی تھے۔جن کی خدمت میں وہ مسلسل سات برس یعنی۱۹۱۹ء تک رہے۔استاد نہایت شفیق اورعلم وتحقیق کے بحر ناپیداکنار کا کامیاب شناور اور شاگرد نہایت ذہین اورہمہ طلب وجستجو! پھر کمی کس چیز کی تھی۔ڈاکٹر عبدالستار صدیقی نے فن لسانیات میں وہ کمال پیداکیا کہ یورپ تک میں مشہور ہوگئے۔ جرمنی سے آنے کے بعد وہ علی گڑھ،حیدرآباد اورڈھاکہ رہے لیکن آخرکار الہٰ آباد یونیورسٹی میں عربی کے پروفیسر اورصدر شعبۂ کی حیثیت سے ایسے جمے کہ یہیں سے ۱۹۴۶ء میں ریٹائرڈ ہوئے اوریہیں مستقل طورپررہ پڑے۔اپنے علم و فضل اورلسانیات میں خصوصی وسعت وقت نظر کے باعث جامعات اورارباب علم کے حلقوں میں بڑی وقعت کی نگاہ سے دیکھے جاتے تھے جرمنی زبان میں ان کے مقالہ فضیلت کے علاوہ غالباً کوئی مستقل تصنیف ان کی یادگار نہیں ہے۔تاہم جو مضامین(عربی کے علاوہ...
All mighty Allah (SWT) has created man and made him crown of the nature. For the physical needs of human being, Allah provided him all the needful things. In the same way, Allah (SWT) sent his prophets for the spiritual guidance of mankind. Prophet Muhammad (SAW) was the last messenger of this chain of the prophets. The Prophet hood of Muhammad (SAW) was for the whole of the mankind, for all the people till the day of judgment. Because Allah (SWT) called him the “Seal of the prophets”. And it the gift of Allah to whom he wants to give, he gives. Nobody can achieve this (prophet hood) by its struggle. All the prophets of Allah (SWT) were given instructions through revelation. Some people, who were unable to accept Islam, would make jokes of the teachings of the Prophet (SAW), but he continued his mission and the world witnessed a day when Islam spread all over the world. Some non-Muslims, specially the orientalists, tried to pin point some aspects of the life of the Holy Prophets (in their thinking) but as Allah (SWT) said: And we raised high your name. (Al-Quran: 94: 4) Lesley Hazelton is one of those orientalists. She wrote many books about Islam. Her famous book is “The First Muslim-The Story of Muhammad” in which she has targeted many aspects of the Holy Prophet Muhammad (SAW). This article discusses her views about the Prophet hood, Revelation and the Miracles of the Holy Prophet (SAW). It is out of the human mind to understand the reality of the Prophet hood and revelation. It is the gift of Allah to whom he wants, He gives prophet hood. The family, fame, wealth and physical strength cannot be the reasons for the achievement of Prophet hood. The human mind cannot grab the reality of the revelation.
This thesis divided into four chapters and each chapter includes its own number of derivatives and references. Due to great biological significance of heterocyclic compounds, here in this dissertation we have described synthesis and bioactivities of benzothiazole, thiadiazole and isatin analogs in search of important therapeutic agents. Variety of benzothiazole, thiadiazole and isatin analogs were synthesized, characterized by 1HNMR, 13CNMR and HR-EIMS and screened for enzyme inhibition studies (α-glucosidase, α-amylase and thymidine phosphorylase activities). The results are separately discussed in the forthcoming chapter 1, 2 and 3. In first chapter, Benzothiazole based oxadiazole derivatives (122-144) have been synthesized and evaluated for α-glucosidase inhibition. All analogs exhibited a varying degree of α-glucosidase inhibitory potential with IC50 values ranging in between 0.5 ± 0.01 - 30.90 ± 0.70 μM when compared with the standard acarbose (IC50 = 866.30 ± 3.20 μM). In second chapter, two series of thiadiazole are described. In first series, thiadiazole quinoline analogs (180-209) were synthesized and screened for α-amylase inhibitory potential. Thirteen analogs 180, 181, 182, 183, 184, 185, 201, 202, 204, 205, 206, 207 and 209 showed outstanding α-amylase activity with IC50 values ranges between (0.002 ± 0.60 to 42.31 ± 0.17 μM) which is many folds better than standard acarbose having IC50 value 53.02 ± 0.12 μM. Eleven analogs 190, 192, 193, 194, 195, 197, 198, 200, 201, 202 and xxx 207 showed good to moderate inhibitory potential while seven analogs 187, 192, 195, 199, 200 and 208 were found inactive. In second series, 2-amino-thiadiazole based Schiff bases (211–219) were synthesized and screened for α-glucosidase inhibitory activity. All compounds showed outstanding α-glucosidase inhibition ranging between 2.30 ± 0.1μM to 25.30 ± 0.5μM when compared with the standard inhibitor acarbose having IC50 value 39.60 ± 0.70μM. Among the series, analogs 211, 214, 216 and 217 showed potent α-glucosidase activity which was more active than standard acarbose. The remaining analogs also showed excellent α-glucosidase inhibition. In third chapter, a new class of exceptionally potent isatin based oxadiazole (88-117) has been synthesized and evaluated for thymidine phosphorylase inhibitory potential. All analogs showed potent thymidine phosphorylase inhibition when compared with standard 7-Deazaxanthine, 7DX (IC50 = 38.68 ± 1.12 μM). In chapter four, procedures for different biological assay are described.