العلامة شائسته جل و خدماته العلمية الدينية السياسية

This article highlights the religious, literary and political work of Moulana ShÉista Gul famous by the name of Mathe Mulla of Khyber Puktun Khawa (1303 A. H-1401A. H. 1886A. D-1981A. D MardÉn) He was well-known scholar of Qura’n, ×adith and Fiqah, his great contribution was to promote political awareness in the community with the concept ofTwo Nations Theory by his affiliation with Muslim League under the leadership of Quaid-eAÐam Muhammad Ali JinnaÍ. He was the convener of Jamiat ul AÎfia which was organized by the eminent religious leaders of that time to implement Sharia law in Pakistan. He was devoted to make Islam a living reality during his life time, his literary work is aimed to improve human communication and develop a better understanding among the people of this region. His monumental work was originally in Pashto widely spoken and understood in the North West of Pakistan. He was teaching and preaching Islam nearly in a span of seventy years. The main objective was to alleviate the deteriorating conditions of the Muslim society and to defend it from external threats. He emphasized to bring change and correct the wrong believes and detrimental actions. His theological doctrines influenced his followers and decedents who promoted his mission in the light of writings and ideas expressed by him.

Organoantimony Iii/V As Prospective Antileishmanial and Anticancer Drugs: Synthesis and Characterization

A variety of pentavalent antimonials have been synthesized from the triorganoantimony(V) halides and a variety of carboxylic acids having known biological applications to better understand the medicinal potential of the synthesized assemblies. The successful synthesis of complexes 1A-18A, 1B-10B and 1C-20C was confirmed by melting points, elemental analysis, FTIR, 1H & 13C NMR spectroscopy. The selected finely crystallized complexes have also been analysized through single crystal X-ray diffraction technique. The crystallographic analysis reveals that these complexes are mononuclear in solution as well as in solid state. The carboxylate ligands bind to the antimony(V) atom through oxygen atoms and occupy axial position adopting geometries between distorted trigonal bipyramidal and square pyramidal. Main purpose objective of this study was to investigate anti-leishmanial and cytotoxic/anticancer potential of the synthesized pentavalent antimonials bearing carboxylic acids with a variety of pharmacophores. The activity of these compounds was tested against Leishmanial tropica and human cell lines carcinomas A498 (renal), EVSA-T (breast), H226 (lung), IGROV (ovarian), M19 (melanoma-skin), MCF-7 (breast), WIDR (colon) and MDA-MB-231 and HeLa. Results of biological activities including anti leishmanial and anti-cancer activity demonstrated that the compounds under studies significantly inhibit Leishmania parasite and also showed promising anti-cancer activity. The carboxylic acids showed no considerable results, while p-tolyl (1B-10B) and 2,5-dimethylphenyl (1C-20C) moieties bearing complexes exhibited potent activity compared to the simple phenyl derivatives (1A-18A). The studies also reveal that these compounds have considerable shelflife, reproducibility and stability in solution mediums as used for testing of biological activities. Hence, it is suggested that reported pentavalent antimonials, particularly with p-tolyl and 2,5-dimethylphenyl groups seem to be a safe, reasonable and worthwhile option for the further investigations to hunt the lead therapeutic agents for leishmaniasis and cancer.