خواجہ محمد علی شاہ رحمانی
افسوس ہے کہ گزشتہ جون میں’’برہان‘‘کے خاص مضمون نگار اوررفیق خواجہ محمد علی شاہ صاحب رحمانی کی سہارنپور میں وفات ہوگئی۔مرحوم کی صحت عرصے سے ٹھیک نہیں تھی اس کے باوجود علمی ریسرچ کے کاموں میں لگے رہتے تھے۔ دارالعلوم دیوبند اور مظاہرالعلوم سہارنپور کے ممتازفاضل تھے۔السنۂ مشرقیہ کی بھی بہت سی ڈگریاں ان کے پاس تھیں۔اکابر دیوبند خاص طورپر حضرت الاستاذ علامہ سید محمد انورشاہ صاحب کشمیریؒ اورحضرت مولانا شبیر احمد صاحب عثمانی مرحوم سے والہانہ تعلق رکھتے تھے اوران حضرات کی علمی خصوصیات پران کی گہری نظر تھی۔ پختہ استعداد، واضح العقیدہ مسلمان تھے۔طبیعت میں قناعت اور خودداری کاجوہر نمایاں تھا۔پوری زندگی گوشہ نشینی اور خدمت علم میں بسر کردی۔ جس روزان کی رحلت ہوئی اسی روز کچھ دیر کے بعد ان کے والد ماجد کاسانحہ ارتحال پیش آگیا۔ان کے والد صاحب خانقاہ رحمانی سہارنپور کے سجادہ نشین تھے اور عوام ان سے فیض حاصل کرتے تھے۔رحمھما اﷲ رحمۃ واسعۃ۔
[ستمبر۱۹۶۷ء]
The article titled: the rights of foetus in Islamic law, aims at explaining the rights of foetus without discussing different theories of the scholars in this regards. It also defines the foetus and gives literal and technical meanings besides different stages of foetus mentioned in the Holy Quran and the Hadith. The article explains the rights granted to foetus in the lights of serah before birth and these rights are a binding on the concerned people and violation of foetus’ s rights is prohibited and it is a cognizable offence. The article also discusses the attitude of west regarding foetus rights as the western society is totally ignorant about the rights of foetus and their legislation in this regard is contrary and several western laws are causing the violation of foetus’s rights. Thus, the champions of human’s rights are blind to the rights of foetus which is foundation and beginning of human life and first step for the human race. It is that has given these rights to mankind for the first time and informed human being about their rights through the first human’s rights charter given at the time of the Noble Prophet {blessing of Allah and peace be upon him}. This charter is known as the charter of Madina between the Muslims and the Jews. The article concludes: mankind cannot be protected unless the sperm of man is protected and foetus is protected in the womb of the mother from abortion because these are the future of humanity.
The present study was conducted for the comparative evaluation of Polychlorinated Biphenyls (PCBs) and Organochlorine Pesticides (OCPs) in the serum samples of diagnosed cancer patients and healthy humans of Karachi. Impact of these chemicals on the serum cell free DNA (cf-DNA), Cholesterol, Alkaline Phosphatase and Total Protein contents was also ascertained in the studied cohort. This was a preliminary work on the role of PCBs and OCPs in the etiology of cancer in Pakistan. A random collection of fasting blood samples from diagnosed cancer patients having various malignancies and healthy humans was carried out with informed consent of the donors at various hospitals and health care centers of Karachi. Serum was separated within 2 hours of collection and was used for subsequent analysis. Analysis of PCBs and OCPs was carried out on Gas Chromatograph coupled with Electron Capture Detector. Serum cf-DNA was analyzed on NanoDrop Spectrophotometer while serum Cholesterol, ALP and Total Protein contents were analyzed on Roche/Hitachi diagnostic analyzers. Levels of the seven tested PCBs (PCB 28, PCB 52, PCB 101, PCB 138, PCB 153, PCB 180 and PCB 209) were significantly higher in the cancer group compared with the control group. PCBs were detected in 93.98 % of the cancer cases and 93.75 % of the normal subjects. Mean level of ΣPCBs was found significantly elevated in the cancer group (2.711 mg/kg) compared with the control group (0.536 mg/kg). PCB 52 was the most prevalent chemical with a mean level of 2.044 mg/kg in the cancer group and 0.134 mg/kg in the control group. It was observed that concentrations of PCBs increased linearly with the increasing age of the cancer patients. On the other hand, OCPs were detected in 97.59 % of the cancer cases and 93.75 % of the normal subjects. Mean concentration of total OCPs was found elevated in the cancer group (0.611 mg/kg) compared with the control group (0.321mg/kg). Endosulfan was the highest prevalent OCP with mean concentration of 0.214 mg/kg in the cancer group and 0.170 mg/kg in the control group. DDT metabolite - 4,4-DDE was found significantly elevated in the cancer group with a mean level of 0.131 mg/kg compared to the control group (0.020 mg/kg). Highest mean concentration of ΣPCBs was found in cases of the female genital system while highest mean of ΣOCPs was detected in the breast cancer cases. Significantly elevated level of cf-DNA was detected in the cancer group with a mean value of 5584.2 ng/μl compared with control group (1758.8 ng/μl). Detection of cf-DNA was 56.45 % in the cancer group and 36.84 % in the control group. Mean cholesterol level was found significantly diminished in the cancer group (116±22 mg/dl) compared with the control group (158.7±33 mg/dl). ALP activity was found elevated in the cancer cases with a mean level of 125±48 U/L compared with the normal counterparts (109±28 U/L). Mean total protein contents were found reduced in the cancer cases (6.2±0.58 g/dl) compared to normal subjects (7.2±1 g/dl). Cases having higher residues of PCBs and to some extent of OCPs has shown elevated concentrations of cf-DNA, comparatively higher levels of cholesterol and ALP and reduced total protein contents. In light of the obtained results, it has concluded that PCBs and OCPs are positively associated with the etiology of cancer. Moreover, PCBs and OCPs adversely affect other biological parameters of the body which may ultimately result into various cancers in humans.