ڈاکٹر ابومحمد سحر
ڈاکٹر ابو سحر ۲۹؍ اپریل ۲۰۰۲ء کو شب میں بھوپال میں انتقال کرگئے، دوسرے دن صبح سیفیہ کالج بھوپال سے ملحقہ قبرستان میں تدفین ہوئی، وہ اردو کے مشہور ادیب و شاعر تھے، انہوں نے الٰہ آباد یونیوورسٹی سے اردو میں ایم۔اے کیا اور آگرہ یونیورسٹی سے امیر مینائی پر تحقیقی مقالہ لکھ کر پی۔ایچ۔ڈی کی ڈگری حاصل کی۔ بعد میں یہی مقالہ ترمیم و اضافے کے بعد ’’مطالعۂ امیر‘‘ کے نام سے کتابی صورت میں شائع ہوا۔
مرحوم سحر صاحب کو اردو شاعری کی صنف قصیدہ نگاری سے بڑی دلچسپی تھی ان کی سب سے پہلی کتاب اسی موضوع پر اردو میں قصیدہ نگاری کے نام سے ۱۹۵۸ء میں چھپی، یہ مختصر ہونے کے باوجود موضوع کے تمام پہلوؤں کو محیط ہے، اس میں قصیدہ سے متعلق بڑی محنت و تحقیق سے مفید و مستند معلومات جمع کئے گئے ہیں۔ ڈاکٹر صاحب کی دلچسپی کا ایک موضوع غالبیات بھی تھا، زبان و لغت و املا اور اس کی اصلاح کے متعلق بھی تحریری نقوش چھوڑے ہیں، اردو میں قصیدہ نگاری اور مطالعہ امیر کے علاوہ ان کی یہ یادگاریں بھی ہیں، تنقید و تجزیہ، انتخاب قصائد اردو مع مقدمہ و حواشی، غالبیاتؔ کے چند مباحث اردو املا اور اس کی اصلاح، زبان اور لغت۔
شاعری کی جانب جناب سحر کاطبعی میلان تھا۔ اسی راہ سے وہ ادب کے میدان میں داخل ہوئے تھے، ان کی شاعری کا آغاز نظم نگاری سے ہوا، پھر غزلیں، قطعات اور رباعیاں بھی کہیں، ابتدائی کلام محفوظ نہیں، رکھا آخر میں شعر کہنے کی رفتار سست ہوگئی تھی تاہم شعر کہنے کا سلسلہ ہمیشہ جاری رہا اور ـ’’برگِ غزل‘‘ کے نام سے شعری مجموعہ بھی چھپا۔
ابو محمد سحر کم آمیز، کم سخن سنجیدہ اور باوقار شخص تھے، شورش وہنگامے سے دور رہتے تھے گوشہ نشینی...
Abstract: Prophets and Messengers have the holiest status amongst Allah’s creation. They are the caliph of Allah in the world. Allah’s characteristics which can be present in a human after Him are present in Prophets and Messengers. That’s why Umma believes in their innocence. The purpose of their prophecy is guidance and breeding of the humanity. One of the most effective tool for breeding is that the breeder must possess the qualities which bring people closer to him. For this reason، Prophets/Messengers should be free and away from all hateful and bad habits. Some hadiths from the Hadith books are seen which appear inappropriate and against prophets grace and honor. That’s why some people have rejected those hadiths for being against prophets’ honor. In this article، we will discuss the hadith present in Sahih Bukhari and Sahih Muslim which appear against the honor of the prophets.
Leishmaniasis, a worldwide prevalent disease, is still enjoying the ruling with no proper medication; and to add to this current gloomy scenario the disease causing parasite Leishmania is becoming resistant to the ongoing medication that is being practiced now a days. Hence, the need is to search for reasonable, safe and targeted drugs; the present research is one such effort in this direction. To begin with, Leishmanolysin (GP63), zinc metalloprotease, expressed over the surface of Leishmania species was selected as drug target due to its virulence and reason for parasite resistance. A library of benzimidazole derivatives (1-37) was synthesized and screened for its antileishmanial potential against L. major. All the compounds were found potent antileishmanial with IC50 values in the range of 0.62-0.92 μg/mL as compared to amphotericin B (standard drug) IC50 value 0.56 μg/mL. 2-(Thiophen-2-yl)-1H- benzimidazole (19) and 2-(1H-indol-3-yl)-5-nitro-1H-benzimidazole (34) were identified as the lead compounds of the library with IC50 value of 0.62 μg/mL. ADMET properties of the entire library were also predicted by using ADMET PredictorTM and were observed to be safe. Molecular docking studies carried out on all the members of library and amphotericin B by using MOE software, indicated that the most active compounds fitted at the centre of binding pocket of GP63 built by amino acid residue His264, His268, His334 and Zn578. On the basis of molecular docking results, receptor based pharmacophore model was built containing three Aro|Hyd features and one Acc&ML feature. This pharmacophore model was used to design new scaffolds for antileishmanial compounds. Four libraries, 2-(2- aryl/heteroarylbenzimidazol-1-sulfonyl)anthraquinones (38-69), N-(heteroaryl)-anthraquinon-2- sulfonamides (70-95), aryl anthraquinon-2-sulfonates (96-111) and N-(anthraquinon-2-sulfonyl)-amino acid methylesters (112-123) were designed and all the cmpounds were found as hit by pharamocophoric search. Their antleishmanial activities were predicted by QSAR model; built by MOE software by selection of 94 descriptors and partial least square (PLS) method on experimental antileishmanial activity of 37-mebered library and amphotericin B, validated by internal and exernal test sets with correlation coefficient (R2) 0.7762. All the compounds belonging to four libraries (38-69, 70-95, 96-111 and 112- 123) were found potent antileihmanial with predicted activity in the range of 0.5435-0.9940. All the compouds were observed safe according to predicted ADMET properties and Lipinski’s rule of five (Ro5). Later, these four designed libraries were synthesized and characterized by physical constants and spectroscopic techniques for onward screening for their antileishmanial potential against L. major by using amphotericin B as standard control which confirmed that all the compounds were potent antileishmanial. Compliance of the predicted activity by QSAR model with observed activity from in vitro antileishmanial activity resulted in identification of the same lead compounds in each library 38-69, 70-95, 96-111 and 112-123 i.e. 2-(5-Nitro-4-methoxyphenyl-1H-benzimidazol-1-sulfonyl)anthraquinone (61) (predicted activity 0.6794, IC50 0.67 μg/mL), 2-(1H-benzo-1,2,3-triazol-1-sulfonyl)anthraquinone (91) (predicted activity 0.5579, IC50 0.57 μg/mL), 2-(1H-pyrazol-1-sulfonyl)anthraquinone (90) (predicted activity 0.5435, IC50 0.58 μg/mL), benzyl anthraquinon-2-sulfonate (100) (predicted activity 0.7615, IC50 0.76 μg/mL) and N-(anthraquinon-2-sulfonyl)-2-phenylglycine methylester (123) (predicted activity 0.7305, IC50 0.75 μg/mL). Pharmacophore based molecular docking studies carried out on all the eighty six compounds on GP63 by MOE software showed hydrophobic interactions, hydrogen bonding and metal ligation interactions with His268, His264, His334 and Zn578, respectively. This entire set of experiments in both dry and wet labs led to a successful designing of a variety of anthraquinon-2- sulfonamides as a novel scaffold having strong antileishmanial effect.