Phase-dependent expression profiling and quantification of several growth factors in liver regeneration after partial hepatectomy

Growth factors are the potential operational members which control different phases of liver regeneration. Different growth factors have expression regulation in the whole process relating to different phases of liver regeneration. Objective: To assess the expression regulation of different growth factors and cytokines involved in liver regeneration in a phase-dependent manner. Methods: Blood and liver samples were collected and analyzed on 1st, 3rd, 5th, 7th and 14th postoperative days after 50% Partia hepatectomy (PHx). Results: Steady increase of liver regeneration rate was recorded from 90.8% (1st day) to 97.9% (7th day). Liver function tests further confirmed the steady liver recovery in PHx mice. Several growth factors such as HGF and VEGF exhibited an up-regulation till 5th day and later gradual decrease till 14th day compared to control mice. Albumin, CK18 and CK19 showed sequential expression increase from 1st to 14th day compared to AFP and HNF-4α upregulated until 5th and 1st day, respectively. Quantification of these growth factors further confirm our results. Conclusions: Conclusively, these results highlight a phase-dependent regulation and role of growth factors in liver regeneration and recovery

Afghan Ethnic and Social Politics Depicted in ‘The Kite Runner’

This work attempts to examine the depiction of ethnic disparity between the Pashtun and Hazara in the novel, The Kite Runner. It argues that the ethnic disparity between the Pashtun and Hazara exists in the novel. It also argues that an internal orientalist discourse is embedded in the text of the novel. The Kite Runner is the first novel in English written by Khaled Hossenei, an Afghan-American (and Hazara), in the United States, in 2003. It portrays the ethno-political culture of Afghanistan from the end of monarchy (1973) till the fall of Taliban regime (2001). The story revolves around two characters: Amir, an ethnic Pashtun, Sunni, and wealthy, and Hassan, servant of Amir‘s father, an ethnic Hazara, Shia. Novel writing/reading began, in Afghanistan, in the early 20th century, while, ethnicity became salient in last three decades of the century. Afghanistan is a multi-ethnic state, comprising more than 50 ethnic groups, though, the Afghan Constitution, 2004, recognizes only 14 ethnic groups: Pashtun, Tajik, Hazara, Uzbek, Turkmen, Baluch, Pashai, Nuristani, Aimaq, Arab, Kirghiz, Qizilbash, Gujar, and Brahui. The Pashtun, Tajik, Hazara, and Uzbek are the major ethnic groups, in the order respectively, whose coethnics reside in the neighbouring states of Afghanistan such as, Pakistan, Tajikistan, Iran, and Uzbekistan. The ethnic Pashtun ruled the country throughout its history since 1747, barring two brief spans (1929 and 1992-94) when ethnic Tajik ruled. This work employs internal orientalism as its theoretical framework and applies analytical and interpretive methods. To explore discourse of ethnic disparity in The Kite Runner, Michel Foucault‘s method of discourse analysis has been applied in chapter 5. Hence, Hossenei‘s relevant statements regarding ethnic: divisions, disparity; polarity; especially, between the Pashtun and Hazara, have been analyzed and interpreted. Chapter 1 attempts to develop a conceptual base and theoretical framework.It provides an overview of the geography, charting various Afghan ethnic groups and estimates major ethnic groups on the basis of available surveys and sources in Afghanistan: Pashtun 44%; Tajik 29%; Hazara 9%; Uzbek 7% and other smaller ethnic groups constitute around 11% of the Afghan population. It also describes instances of forced displacement of tribes and ethnic cleansing in Afghanistan, besides introducing the novel, The Kite Runner, its author, Khaled Hossenei. It states research questions, hypotheses, theoretical framework and methodology too. Chapter 2 argues that qaum, a flexible term, referring to (kin, clan, village, tribe, ethnic/vocational/confessional group, profession, and/or nation) and ethnicity became salient in Afghanistan during the last three decades of the 20th century. It examines how the promulgation of 1964 Constitution in Afghanistan stirred political struggle between various ethnic groups, the Pashtun and non-Pashtun, for power, and, how, the Soviet invasion, in 1979, stimulated and politicised ethnicity. It further describes how, conversely, the Mujahideen (1992-96) and the Taliban (1996-2001), though Islamists, ethnicised politics that resulted into ethnic: violence; cleansing; and/or conflict. Ethnicity became further salient during the post-Taliban periods due to power sharing arrangements on ethnic basis. The review of existing literature on the topic in Chapter 3 points out that ethnic division, polarity, and conflict as core issues have been strengthened in Afghanistan during the last three decades of the 20th century. Sectarianism and ethnic: mobilization; cleansing also increased. During this period, foreign interference and warlordism increased ethnic and sectarian polarization, however, it did not spread to the masses. The neighbouring states of Afghanistan: Pakistan; Tajikistan; Iran; Uzbekistan; comprising a population of same ethnicity, have a natural advantage to meddle into the political affairs of Afghanistan. Chapter 4 discusses the origin and evolution of novel in Afghanistan in the 20th century. It establishes that dastan (romances) existed prior to the advent of novel in the early 20th century. It further establishes that French novel was imported into Afghanistan, in form of translation, through Sirajul Akhbar, from Turkish sources. Novel introduced Afghans to, non-existent in dastan, realism in story, character development, and plot. Imported Tajik/Soviet/Kirghiz/ Persian/Russian, and American novels have impacted the Afghan novel. The important Tajik and Kirghiz novels included: Margi Sudkur, Yatim, Gulomon, Jalladon-e Bokhara; of Sadriddin Ayni; Jamila: of Chingez Aitmatov. American novels included: White Fang of Jack London and The Grapes of Wrath of John Ernst Steinbeck.Earlier indigenous Afghan novels such as, Paighla (1950) of Sahibzada Muhammad Idrees, Be-Tarbiata Zoi (1939-40) of Noor Muhammad Taraki in Pashto, and Jihad-e Akbar (1919) of Molvi Muhammad Hussain Panjabi, Begum (1930) of Suleman Ali Jaghori in Dari, written in the 20th century, reflected societal realities. Chapter 5 establishes on the basis of interpretation and analysis of Hossenei‘s statements of ethnic politics in The Kite Runner that Pashtun is superior but treacherous; unimaginative, brutal, and aberrant, while Hazara, inferior but loyal; imaginative, humane, and protector. There exists a binary of Us (Hazara) and Them (Pashtun) in the novel. The treachery of Pashtun character, and the portrayal of Taliban confining as ethnic Pashtun is vilifying in the novel. Besides, Hossenei has eulogized the USA; therefore, the novel may also be considered an apology for the War on Terror in Afghanistan. Chapter 6 concludes that Hossenei‘s depiction of ethnic disparity in the novel seems exaggerated. He created a schism between Pashtun and Hazara with the help of orientalist knowledge and power. The division of Us (Hazara) and Them (Pashtun) in the novel is exaggerated, misleading and biased.