External and Internal Factors of Political-Religious Violence and Pakistan’s Role: Unravel Threats for the Security of Modern Islamic State

Political scientists and Islamic philosophers have long been discussing the different phenomena of violence. This article analyzes external and internal factor of violence in Pakistan, interpreting the religious and political dimension of the violence. The presence of external and more specifically internal factors are the real threats for the security of the country. Building from theoretical approaches, I fielded two dimensions of the political-religious violence, violence inside the country and outside the country. It is found out, on the one hand, that the both dimensions can be met with the profound enforcement of the law. On the other hand, both dimensions of the violence can be the big contributory factors of violence due to the poor promulgation of the law. Unjust political-religious dispensation inside the country rise the frustration, and outside support make it fertile and leads it towards violence. It is proposed that on equity bases, political-religious deprivation and absolute deprivation of the minority elite class can be disposed of. I also come up with balanced educational system, which should be the blend of traditionalism and modernism for the fulfilment of our spiritual dimension and for the greater understanding of our political-religious outlook.

Exploring Hepatoprotective and Regenerative Natural and Synthetic Compounds for the Treatment of Hepatitis

It is widely known that hepatitis and its complications such as cirrhosis or hepatocellular carcinoma are one of the major health problems of the world especially since no specific treatment is available. In the present study we investigated the hepatoprotective and regenerative potential of the methanolic extract of the whole plant of Dodonaea viscosa and its ethyl acetate, aqueous, butanol and n-hexane fractions against carbon tetrachloride (CCl4) induced hepatoxicity in rats. Hepatoprotection was assessed in terms of reduction in serum enzymes (ALT, AST, and ALP) that occur after CCl4 injury, and by histopathology and immunohistochemistry. The methanolic extract reduced the serum enzyme level (ALT, AST, and ALP) down to control levels despite CCl4 treatment. It also reduced the CCl4-induced damaged area to 0% as assessed by histopathology. The CD68+ macrophages were also reduced in number around the central vein area by the methanolic extract. These hepatoprotective effects were better than the positive control silymarin. Similar hepatoprotective activities were found with the ethyl acetate, and aqueous fractions of the methanolic extract. The butanol and n-hexane fractions showed elevated levels of ALT, AST and ALP as compared to the positive control silymarin. Histopathology showed ~30% damage to the liver cells with the butanol and n-hexane fractions which still showed some protective activity compared to the CCl4 treated control. HPLC fingerprinting suggested that hautriwaic acid and viscosine present in the methanolic extract and its ethyl acetate, and aqueous fractions may be responsible for this hepatoprotective activity of Dodonaea viscosa which was confirmed by in-vivo experiments. Another, novel approach was used to investigate the hepatoprotective and anti-cirrhotic effect of silymarin and viscosine coated gold nanoparticles, a trend towards nanomedicine.