الباب الرابع: شعر نازك الملائكة وبروین شاکر (دراسة مقارنة)

Welcome to the inaugural Issue of Pakistan BioMedical Journal

Firstly, I would like to welcome all the readers, authors, editorial team and management of Pakistan Biomedical Journal (PBMJ) to this new journal in Biomedical Sciences. It is an intenational peer-reviewed, open-access journal that merges the basic and clinical research for the better outcome in terms of diagnosis and therapeutics. This approach will update and upgrade the existing knowledge among the researchers and clinicians, regarding the patient care and practice as well as understanding of underlying mechanisms of diseases. The ultimate beneficiary is patient and community as a whole. PBMJ is led by an outstanding Editorial Board comprising of national and international members with multidisciplinary research background. Our goal is to promote the basic and clinical research, health and disease perspectives. We receive original studies, review articles, case reports, systemetic reviews on medical, biomedical, basic and therapeutic research. We welcome scientific contributions from all over the world. It is the need and demand of the recent world scenario to focus on biomedical research. In the current world, basic and medical science cannot be considered as two separate and independent entities. There should be coherent efforts to unveil the basic understandings of pathologies at physiological, cellular and molecular level. Furthermore, the therapeutic strategies should also be explored on regional and global levels, by keeping in mind the different genetic makeups and considering the individual identities. It leads to the field of ‘personalized medicine’. There are many other recent therapeutic regimens such as regenerative medicine, exosomes, gene silencing and gene editing technologies. The world has also advanced in diagnostic modalities. Much focus has been emphasized on rapidness, accuracy and cost-effectiveness of these techniques. Imaging, scanning, histopathological, biochemical and hematological techniques have been much advanced than before. World has been changing rapidly in medical profession. Hence, it is important to be aware of these advancements worldwide and also to share the health related researches at local level. We hope this new journal will be a good addition in this perspective of sharing the recent knowledge, advancements and create awareness among masses.

Investigation of Antidiabetic Potential of Parthenium Hysterophorus Carrot Grass on Alloxan Induced Diabetic Rabbits

Parthenium hysterophorus is of great medicinal importance. It has been used to cure fever, malaria, diarrhea, dysentery, and neurologic disorders. It also has anticancer agents as well. This study evaluates the antidiabetic effects of methanolic extract of all plant parts of Parthenium hysterophorus in diabetic rabbits (alloxan-induced). Twenty-five rabbits were divided into 5 groups (N=5). The group I served as a standard control. Groups II to V were injected with freshly prepared alloxan solution 150mg/kg intraperitoneally to induce diabetes. Glucose levels were checked to ensure hyperglycemia (diabetes). Group II till V received these treatments. Group II: Alloxan 150mg/kg alone; group III: Alloxan + MEPH (50mg/kg); group IV: Alloxan +100mg/kg MEPH (100mg/kg); group V: Alloxan +Glucophage (62.5mg/kg) respectively for a period of 10 days orally via feeding cannula. The safety assessment of these extracts was carried out in rabbits by oral administration with 50mg/kg, 100mg/kg& 150mg/kg body weight daily for7 days. They remained normal at the dose of 50g/kg, 100g/kg whereas, they showed anxiety in their behavior at high dose i.e., 150mg/kg. Changes in the body weight of all animals were recorded on day 1 , 7 st th 4 th and 10 and 10 th days. Short term (1 st , 3 rd , 5 th and7 th hour) and long term (4 th , 7 th th day) hypoglycemic effect were recorded using easy glucometer C 20. All animals were sacrificed on 10 day to isolate the pancreas for histopathological examination. The results showed that Parthenium hysterophorus L. lowers the blood glucose level in all the groups of alloxan-induced diabetic rabbits. However, the swift reduction in blood glucose level with MEPH was comparatively less than the experimental standard drug i.e., Glucophage.The Pancreatic histopathological studies depicted that a high dose of MEPH administration repaired alloxan-induced pancreatic damage. Whereas, Glucophage only reduced blood glucose level as no repair in damaged tissue was observed in the histopathological study of Glucophage treated animals. The study shows that the whole plant of Parthenium hysterophorus L. is very useful for developing effective phytomedicine to treat diabetes mellitus. The present investigation recommends the use of Parthenium hysterophorus as an herbal remedy for diabetes